A5066320106- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Body Contouring and Surgery
- Burn Injury Management and Outcomes
- Extracellular vesicles in disease
- Organ and Tissue Transplantation Research
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- Bone fractures and treatments
- COVID-19 and healthcare impacts
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Frailty in Older Adults
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Diversity and Career in Medicine
- Breast Cancer Treatment Studies
- Bone Metabolism and Diseases
- Reconstructive Facial Surgery Techniques
- Tendon Structure and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Disaster Response and Management
Brigham and Women's Hospital
2017-2025
Harvard University
2017-2025
Ludwigshafen University of Business and Society
2022-2025
Heidelberg University
2022-2025
Charité - Universitätsmedizin Berlin
2025
Klinikum Ludwigshafen
2023-2025
Humboldt-Universität zu Berlin
2025
Freie Universität Berlin
2025
Berufsgenossenschaftliche Unfallklinik Ludwigshafen
2024
University Hospital Heidelberg
2022-2023
Abstract The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic characterized by multiple drug‐resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, novel situ injectable HA@MnO 2 /FGF‐2/Exos hydrogel is introduced for improving wound healing. Through simple local injection, this able form protective barrier covering wound, providing rapid hemostasis long‐term antibacterial protection. MnO /ε‐PL nanosheet...
Abstract Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, promising candidates for the treatment of The present study aimed to investigate effect exosomes derived from MSCs pretreated with pioglitazone (PGZ-Exos) on Results We isolated PGZ-Exos supernatants pioglitazone-treated BMSCs and found that significantly cell viability proliferation Human Umbilical Vein Vascular Endothelial Cells...
Diabetic wounds represent a pressing concern affecting the health and quality of life patients. Despite continuous improvement in therapeutic strategy, diabetic remain worldwide challenge. Vascular dysfunction, part due to hyperglycemia, is well-identified factor contributing inadequate healing wounds. In current study, we utilize an extrusion-based cryogenic 3D printing technology construct decellularized small intestinal submucosa (SIS) combined with mesoporous bioactive glass (MBG)...
The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed fracture healing. Robust osteoblast differentiation M2 polarization can substantiality promote repair; however, the combined effect of these strategies has not been previously studied. In this study, we constructed a cocktail therapy to simultaneously regulate balance. composed natural polymer hyaluronic-acid-based hydrogel (HA hydrogel, which tissue-adhesive, injectable, self-healing, anti-inflammation...
Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune...
Reconstructive surgery remains inadequate for the treatment of volumetric muscle loss (VML). The geometry skeletal defects in VML injuries varies on a case-by-case basis. Three-dimensional (3D) printing has emerged as one strategy that enables fabrication scaffolds match defect site. However, time and facilities needed imaging site, processing to render computer models, suitable scaffold prevent immediate reconstructive interventions post-traumatic injuries. In addition, proper implantation...
Abstract Extremity skeletal muscle injuries result in substantial disability. Current treatments fail to recoup function, but properly designed and implemented tissue engineering regenerative medicine techniques can overcome this challenge. In study, a nanoengineered, growth factor‐eluting bioink that utilizes Laponite nanoclay for the controlled release of vascular endothelial factor (VEGF) GelMA hydrogel supportive adhesive scaffold be crosslinked vivo is presented. The delivered with...
MicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the progression fracture healing osteoporosis. Recently, it has been reported that miR-1224-5p in plasma is a potential therapy for osteogenesis. To investigate roles Rap1 signaling pathway osteoporosis development progression, we used BMMs, BMSCs, skull osteoblast precursor cells vitro osteogenesis osteoclastogenesis studies. Osteoblastogenesis were detected by ALP, ARS, TRAP staining slice resorption pit assays....
Fracture nonunion remains a great challenge for orthopedic surgeons. repair comprises of three phases, the inflammatory, and remodeling stage. Extensive advancements have been made in field bone repair, including development strategies to balance M1/M2 macrophage populations, improve osteogenesis angiogenesis. However, such developments focused on only one or latter two while ignoring inflammatory phase during which cell recruitment occurs. In this study, we combined Stromal Cell-Derived...
Ongoing research has highlighted the significance of cross-play macrophages and mesenchymal stem cells (MSCs). Lysine-specific demethylase 6B (KDM6B) been shown to control osteogenic differentiation MSCs by depleting trimethylated histone 3 lysine 27 (H3K27me3). However, date, role KDM6B in bone marrow-derived (BMDMs) remains controversial. Here, a chromatin immunoprecipitation assay (ChIP) proved that derived from osteogenic-induced BMSCs could bind promoter region BMDMs' brain muscle aryl...
Background: The potential of robot-assisted surgery in plastic and reconstructive remains to be established, especially free tissue transfer. This prospective study aimed present our experience findings from the first 50 consecutive cases microsurgery using Symani surgical system. Methods: A database was maintained, recording patient demographics details for all a large academic institution. All surgeons underwent an intensive training program with Results: total patients who microsurgical...
Diabetic foot ulcers (DFUs) are a significant challenge in the clinical care of diabetic patients, often necessitating limb amputation and compromising quality life expectancy this cohort. Minimally invasive therapies, such as modular scaffolds, at forefront current DFU treatment, offering an efficient approach for administering therapeutics that accelerate tissue repair regeneration. In study, we report facile method fabricating granular nanofibrous microspheres (NMs) with predesigned...