A5103014892- Environmental Toxicology and Ecotoxicology
- Nerve injury and regeneration
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Glutathione Transferases and Polymorphisms
- Electrospun Nanofibers in Biomedical Applications
- Toxic Organic Pollutants Impact
- Cancer, Hypoxia, and Metabolism
- Bone fractures and treatments
- Mycobacterium research and diagnosis
- Orthopedic Surgery and Rehabilitation
- Wnt/β-catenin signaling in development and cancer
- Treatment of Major Depression
- Free Radicals and Antioxidants
- Aquaculture Nutrition and Growth
- Immunotherapy and Immune Responses
- Bacterial Identification and Susceptibility Testing
- Curcumin's Biomedical Applications
- Spinal Hematomas and Complications
- Escherichia coli research studies
- Shoulder and Clavicle Injuries
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Spaceflight effects on biology
- Pharmacological Effects of Natural Compounds
Shanghai First People's Hospital
2010-2021
Shanghai Jiao Tong University
2015-2020
Jinhua Central Hospital
2019-2020
Virginia State University
2013
Yanbian University
2009
Yale University
2008
State Key Laboratory of Pollution Control and Resource Reuse
2003-2005
Nanjing University
2003-2005
Abstract TLR4 is a unique TLR because downstream signaling occurs via two separate pathways, as follows: MyD88 and Toll IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-β (TRIF). In this study, we compared contrasted the interplay of these pathways between murine dendritic cells (DCs) macrophages during LPS stimulation. During activation, neither pathway on its own was critical for up-regulation costimulatory molecules in DCs, whereas largely TRIF dependent macrophages. LPS-induced...
To investigate the function of miR-126-3p loaded on adipose stem cell (ADSC)-derived exosomes (ADSC-Exos) in wound healing full-thickness skin defects.ADSCs transfected with mimic, inhibitor or pcDNA3.1-PIK3R2, PKH26-marked ADSC-Exos were cultured fibroblasts human umbilical vein endothelial cells (HUVECs). The proliferation and migration rates angiogenesis HUVECs measured. Rats defects injected extracted from ADSCs bed, collagen deposition injured rats assessed.ADSC-Exos could be ingested...
Combinations of fibroblasts (Fbs) and corresponding epithelial cells have been widely used in many tissues, such as the skin breast to augment tissue repair remodeling.Recently, a large amount new data has indicated that nerve Fbs play critical roles Schwann (SCs) axons vitro.However, little is known regarding effects co-transplanting SCs on peripheral vivo.The aim this study was investigate effect sciatic (SN-Fbs) (SN-SCs) regeneration.We developed 5 mm nerve-defect model mice using...
Abstract A variety of nerve conduits incorporated with chemical and biological factors have been developed to further stimulate regeneration. Although most the guides in studies are basically limited bridge a short gap defect rat models, it is vital evaluate effects on regeneration over distance greater than 20 mm, or more clinically relevant lengths higher mammals. In this study, poly(lactide‐ co ‐glycolide) (PLGA) conduit, treated pulsed plasma coated ciliary neurotrophic factor (CNTF) as...
Abstract Background Pancreatic adenocarcinoma (PDAC) is one of the most fatal malignancies. Surgical resection supplemented by chemotherapy remains major therapeutic regimen, but with unavoidable resistance and systemic toxic reaction. Curcumin a known safe natural compound that can effectively eliminate pancreatic cells in vitro, making it promising candidate for substitution subsequent chemotherapy. However, due to its extremely low bioavailability caused insolubility circular elimination,...
Abstract Schwann cells (SCs) can promote the regeneration of injured peripheral nerves while clinical application is limited by donor site complications and inability to generate an ample amount cells. In this study, we have isolated human eyelid adipose-derived (hE-SCs) from adipose tissue identified cell phenotype function. Using immunofluorescence H & E staining, detected subtle nerve fibers SCs in tissue. Immunofluorescence staining indicated that hE-SCs expressed glial markers, such...
Background. Black people in the USA is afflicted with a higher rate of methicillin-resistant Staphylococcus aureus (MRSA) infection. This study determined prevalence MRSA carriage among black college students at university setting. Methods. Hand and nasal swabs were collected screened for by mannitol fermentation, coagulase, DNase activities their resistance to oxacillin. isolates analyzed antimicrobial pattern, genetic profile staphylococcal cassette chromosome mec (SCCmec) type,...
This is the first report of antioxidant response Daphnia magna following a short-term to water soluble fractions no. 20 diesel oil. was exposed for 24h nominal concentrations 0, 0.005, 0.01, 0.05, 0.1, 0.5 or 1.0 mg/L Following this exposure, activities catalase (CAT) and glutathione S-transferase (GST) were induced significantly on whole compared control group; activity selenium-dependent peroxidase (Se-GPx) inhibited whole; superoxide dismutase (SOD) only responded oil exposure at two...
Schwann cells (SCs) are indispensable for cell therapy and tissue engineering of the peripheral nervous system. Easy access to activated, highly proliferative SCs is necessary clinical applications. The present study developed a fast, efficient method obtaining purified from nerve mature Rhesus monkey. common peroneal nerves 4‑year‑old monkeys were harvested subjected in vitro pre‑degeneration modified SC culture medium (SCCM). pieces subsequently treated enzymatically dissociate then...
Objective To study the clinical results of using compression lag screws for treatment Bennett's fracture.Methods From May 2010 to October 2013,sixteen patients with fracture were treated in our department.Three-dimensional CT was done and size fragment measured before operation.Fracture fragments at volar side first metacarpal base 7.5 mm× 6.7 mm 2.2 × 2.5 mm.The average 3.4 4.5 mm.There 6 cases whose transverse dimension over 6.0 mm.A K-wire used stabilize second after reduction.A screw...
目的 探讨微型钛板螺钉联合克氏针内固定治疗近、中节指骨粉碎性骨折的临床疗效。 方法 回顾性分析2012年2月—2015年10月上海交通大学附属第一人民医院整形外科手术治疗的近、中节指骨粉碎性骨折55例(58指)患者的临床资料，其中近节34例36指、中节21例22指；拇指近节6指，余四指近节30指、中节22指。51指采用微型钛板螺钉内固定治疗，7指应用微型钛板螺钉联合克氏针内固定治疗；指骨背侧固定42例，侧方固定16例。 结果 术后随访6～15个月，平均随访10个月。所有患者伤口Ⅰ期愈合，术后未发现钛板螺钉松动、变形或断裂者，无一例发生骨折不愈合和关节僵硬。骨折均达到解剖复位；骨折愈合时间10～24周，平均17周。按照TAM标准评价术后手指功能：优37指、良18指、差3指，优良率为94.8%。 结论 采用微型钛板螺钉联合克氏针治疗近、中节指骨粉碎性骨折，操作简便、创伤小、固定可靠，术后可以早期功能锻炼，利于手指功能的康复。