A5101914156- Advanced X-ray and CT Imaging
- Advanced X-ray Imaging Techniques
- Medical Imaging Techniques and Applications
- Digital Radiography and Breast Imaging
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Advanced MRI Techniques and Applications
- Sensor Technology and Measurement Systems
- Lipid Membrane Structure and Behavior
- Scientific Measurement and Uncertainty Evaluation
- Chemical Synthesis and Analysis
- Advanced optical system design
- Ultrasound Imaging and Elastography
- Spectroscopy Techniques in Biomedical and Chemical Research
- Radioactive Decay and Measurement Techniques
- Industrial Automation and Control Systems
- Fire dynamics and safety research
- Electron and X-Ray Spectroscopy Techniques
- Adaptive optics and wavefront sensing
- Radiation Shielding Materials Analysis
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Nantong University
2024
National Institute of Metrology
2020-2021
University of Oklahoma
2012-2019
Main text This report describes the second CCM key comparison of realizations kilogram definition based on fixed numerical value Planck constant, which came into force 20 May 2019. The objectives were to determine level agreement between using Kibble and joule balances x-ray crystal density (XRCD) method provide input for calculation "consensus value" kilogram. consensus serves as basis an internationally coordinated dissemination is updated after each new comparison. Its use will continue...
Purpose : X‐ray fluorescence (XRF) is a promising technique with sufficient specificity and sensitivity for identifying quantifying features in small samples containing high atomic number (Z) materials such as iodine, gadolinium, gold. In this study, the feasibility of applying XRF to early breast cancer diagnosis treatment studied using novel approach three‐dimensional (3D) x‐ray mapping (XFM) gold nanoparticle (GNP)‐loaded objects physical phantom at technical level. Methods All...
Expression of the Neuropilin-1 (NRP1) is reported in malignant cells multiple human tumor types represented as a marker. Targeting NRP1 with peptide, CK3, used for molecular imaging, raising question therapeutic potential CK2, peptide CK3 backbone which enhanced targeting and enrichment properties. The capacity CK2 was detected by IncuCyte, flow cytometry animal living imaging. To enhance its efficacy, we developed self-assembling nanoparticles Fmoc-Gffy-AP-CK2, incorporating protective...
Targeting imaging and enhanced radiotherapy are very important issues for decrease in diagnosis therapy. Functionalized gold nanostructures show low toxicity excellent optical properties, thus, they can be used as the contrast agent cancer cell imaging. Furthermore, enhance due to strong photoelectric absorption second electron caused by gamma or X-ray irradiation. This critical review provides a recent progress fabrication, properties (especially, fluorescence of nanoclusters), surface...
Purpose: This paper reports a technique that enables the quantitative determination of concentration gold nanoparticles (GNPs) through accurate detection their fluorescence radiation in diagnostic x‐ray spectrum. Methods: Experimentally, spectra 1.9 and 15 nm GNP solutions are measured using an spectrometer, individually within chicken breast tissue samples. An optimal combination excitation emission filters is determined to segregate at 66.99 68.80 keV from background scattering. A roadmap...
In this research, a high-energy in-line phase contrast tomosynthesis prototype was developed and characterized through quantitative investigations phantom studies.
The objective of this study was to demonstrate the potential benefits using high energy x-rays in comparison with conventional mammography imaging systems for phase sensitive breast tissues varying glandular-adipose ratios.
The ability of microbubbles to benefit the imaging quality high-energy in-line phase contrast as compared with conventional low-energy contact mode radiography was investigated. study conducted by comparing contact-mode projection under same dose delivered a phantom. A custom-designed phantom employed simulate segment human blood vessel injected microbubble suspensions. were suspended in deionized water obtain different volume concentrations. area contrast-to-noise ratio (CNR) values...
Accurate background estimation to isolate the fluorescence signals is an important issue for quantitative X-ray (XRF) analysis of gold nanoparticles (GNPs). Though a good can be obtained experimentally through acquiring spectrum water solution, it inevitably leads unnecessary second exposure in reality. Thus, several numerical methods such as trapezoidal shape estimation, interpolation by polynomial fitting and SNIP (Statistics sensitive Nonlinear Iterative Peak-Clipping) algorithm are...
This paper aims to evaluate the impact of spectral filtration on image quality in a microcomputed tomography (micro‐CT) system. A mouse phantom comprising 11 rods for modeling lung, muscle, adipose, and bones was scanned with 17 s 2 min, respectively. The current (μA) each scan adjusted achieve identical entrance exposure phantom, providing baseline evaluation. For region interest (ROI) within specific composition, CT number variations, noise levels, contrast‐to‐noise ratios (CNRs) were...
BACKGROUND: Accurately depicting breast tumors located posteriorly, close to the chest wall musculature, with conventional mammography is a technical challenge. OBJECTIVE: This study demonstrates proof of concept an x-ray fluorescence mapping
The purpose of this study was to determine the Contrast Noise Ratio (CNR) x-ray images taken with phase contrast imaging mode and compare them CNR under conventional mode. For each mode, three were exposure conditions 100 kVp (2.8mAs), 120 (1.9mAs) 140kVp (1.42mAs). A 1.61cm thick detail phantom used as an object. contrast, source image detector distance (SID) 182.88 cm object (SOD) 73.15 cm. SOD same SID in computed radiography (CR) plate a output CR converted linear form relation incident...
The objectives of this project are to intrinsically and quantitatively investigate the advantages a phase-contrast (PC) tomosynthesis prototype in removing superimposed structure noise effects on image qualities by an off-center shift object along tube-sweep direction. Experimentally, phantoms assembled with standard resolution patterns. Phase-contrast images acquired reconstructed. In order study limited angular projections in-plane resolutions, all were reconstructed 2×2 binning mode only,...
The objective of this study was to quantitatively investigate the ability distribute microbubbles along interface between two tissues, in an effort improve edge and/or boundary features phase contrast imaging. experiments were conducted by employing a custom designed tissue simulating phantom, which also simulated clinical condition where ligand-targeted are self-aggregated on endothelium blood vessels surrounding malignant cells. Four different concentrations microbubble suspensions...
X-ray fluorescence (XRF) is a promising spectroscopic technique to characterize imaging contrast agents with high atomic numbers (Z) such as gold nanoparticles (GNPs) inside small objects. Its utilization for biomedical applications, however, greatly limited experimental research due longer data acquisition time. The objectives of this study are apply photon counting detector array XRF and determine an optimized time, at which the acquired image acceptable quality allow maximum level...
This study compares the spatial resolution in step-and-shoot and continuous motion acquisition modes of digital tomosynthesis using a bench-top prototype designed for breast phantoms imaging. The employs flat panel detector with 50 μm pixel pitch, micro focus x-ray tube motorized stage. A sharp metal edge thickness 0.2 mm was used to measure modulation transfer function (MTF). rotated from −7.5° +7.5° 1.5° increments acquire 11 angular projections 40 kVp, 500 μA 5.55 s per projection. In...
The objective of this research is to characterize the detective quantum efficiency (DQE) a high-energy in-line phase contrast prototype operated under different x-ray exposure conditions. First all, an imaging was demonstrated based on system prototype. DQE calculated through modulation transfer function (MTF), noise power spectrum (NPS) and input signal ratio fixed radiation dose. dose estimated by employing 4-cm-thick BR12 phantom. In research, conditions were modified not only using tube...
This research is aimed at studying the advantages of an x-ray phase-contrast tomosynthesis prototype by using phantoms. A system assembled with a micro-focus source, rotating stage and computed radiography detector mounted on optical rail. custom designed bubble wrap phantom used in experiments. Angular projection images are acquired from -20° to +20° 2° interval. The in-plane slices reconstructed. feature area observed. provides intrinsic way investigate potential imaging quality method. As...
Breast cancer has one of the highest mortality rates usually due to metastatic development. Mammograms are current standard diagnosis; however low sensitivity and high rate misdiagnosis, patients either experience false positives or negatives leading overdiagnosis overtreatment. One key disadvantages mammograms is their failed ability differentiate between a dense breast tumor, more expensive diagnostic tools. In order provide widely available imaging tool, targeted gold nanoparticles have...
After the revision of International System Units (SI) in May 2019, Planck constant h became top dissemination system for kilogram. However, is difficult or impractical to use daily calibrations. Thus, many applications, alternative physical artefacts are used as mass standards dissemination. Mass measurements silicon spheres determination Avogadro and constants have shown that possess stability with high accuracy, thus can be utilized standards. material geometry properties different from...
The characteristic performance of a photon counting detector for X-ray fluorescence (XRF) imaging gold nanoparticles (GNPs) is investigated. investigations are first performed in three aspects: energy (keV) to pulse height (mV) conversion, noise floor determination, and linear detection ranges. Then, theoretical models applied evaluate the efficiency photons with respect an increased incident rate. Last, through exciting 100% pure GNPs by conventional tube operated at voltage 110kVp, we...