A5069560221- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic and Hepatic Oncology Research
- Bone health and osteoporosis research
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Bone health and treatments
- Herpesvirus Infections and Treatments
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Nutrition and Health in Aging
- RNA modifications and cancer
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Metabolism, Diabetes, and Cancer
- Cancer Research and Treatments
- Protein Degradation and Inhibitors
- Virus-based gene therapy research
- Toxin Mechanisms and Immunotoxins
- Inflammatory Biomarkers in Disease Prognosis
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
Harvard University
2022-2025
Dana-Farber Cancer Institute
2022-2025
Sun Yat-sen University
2020-2025
Sun Yat-sen University Cancer Center
2020-2025
Sichuan University
2024-2025
West China Second University Hospital of Sichuan University
2025
Henan Agricultural University
2024-2025
Lund University
2025
Science for Life Laboratory
2025
Karolinska Institutet
2017-2024
Herpes simplex virus type 1 (HSV-1) establishes latency in neurons and can cause severe disseminated infection with neurological impairment high mortality. This neurodegeneration is thought to be tightly associated virus-induced cytoskeleton disruption. Currently, the regulation pattern of actin involved molecular mechanisms during HSV-1 entry into remain unclear. Here, we demonstrate that neuronal cells induces biphasic remodeling an initial inactivation followed by subsequent activation...
Abstract Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue skeletal losses begin before diagnosis the potential utility of such for earlier detection are not well understood. We quantify areas from computed tomography (CT) imaging obtained 2 months to 5 years in 714 cases 1748 matched controls. Adipose is identified up 6 months, wasting 18 clinical present control population. Tissue similar magnitude diagnosed localized compared...
Importance Weight loss is common in primary care. Among individuals with recent weight loss, the rates of cancer during subsequent 12 months are unclear compared those without loss. Objective To determine diagnoses over among health professionals prior 2 years Design, Setting, and Participants Prospective cohort analysis females aged 40 or older from Nurses’ Health Study who were followed up June 1978 until 30, 2016, males Professionals Follow-Up January 1988 31, 2016. Exposure Recent change...
Background and aims: Esophageal squamous cell carcinoma (ESCC) is the dominant histological type of esophageal cancer worldwide (90%). We aimed to provide an update global temporal trends in incidence ESCC. Methods: Incidence data for ESCC were collected from 30 well-established registries 20 countries Europe, Northern America, Australia, or Asia 1970–2015. Time annual age-standardized rates assessed using joinpoint analysis log-linear regression. Age–period–cohort was used estimate...
Objective Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed. Design To assess circulating marker discrimination in training, testing and validation patient cohorts (total n=426 patients), plasma markers were measured among cases patients with chronic pancreatitis, colorectal cancer (CRC), healthy controls. Using CA19-9 as anchor marker, measurements...
Abstract KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms play crucial role driving cancer progression conferring resistance to treatment. While there have been advancements the development small molecules target specific mutants, presence undruggable mutants emergence secondary continue pose challenges clinical treatment KRAS-mutant cancers. In this study, we developed novel molecular tool called tumor-targeting degrader (TKD) that effectively...
ABSTRACT Herpes simplex virus 1 (HSV-1) invades the nervous system and causes pathological changes. In this study, we defined remodeling of F-actin its possible mechanisms during HSV-1 infection neuronal cells. enhanced formation F-actin-based structures in early stage infection, which was followed by a continuous decrease later stages infection. The disruption dynamics chemical inhibitors significantly reduced efficiency viral intracellular replication. active form actin-depolymerizing...
Pancreatic cancer is among the most lethal malignant neoplasms, and few patients with pancreatic benefit from immunotherapy. We retrospectively analyzed advanced who received PD-1 inhibitor-based combination therapies during 2019-2021 in our institution. The clinical characteristics peripheral blood inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte [PLR], lymphocyte-to-monocyte [LMR], lactate dehydrogenase [LDH]) were collected at baseline. Chi-squared...
Although it is known that inhibitors of heat shock protein 90 (Hsp90) can inhibit herpes simplex virus type 1 (HSV-1) infection, the role Hsp90 in HSV-1 entry and antiviral mechanisms remain unclear. In this study, we found have potent activity against standard or drug-resistant strains viral gene synthesis are inhibited an early phase. More detailed studies demonstrated upregulated by interacts with virus. knockdown siRNA treatment significantly nuclear transport capsid (ICP5) at stage...
The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) subsequent esophagectomy. This multimodal leads to around 60% overall 5-year survival, yet impaired post-surgical quality of life. Observational studies indicate that curatively intended chemoradiotherapy, so-called definitive (dCRT) followed by surveillance the primary tumor site and regional lymph node stations surgery only when needed...
Background Many clinical studies have shown a correlation between plasma cortisol and neurological disorders. This study explored the causal relationship dementia, epilepsy multiple sclerosis based on Mendelian randomization (MR) method. Methods Data were taken from summary statistics of genome-wide association study, FinnGen consortium United Kingdom Biobank. Dementia, epilepsy, used as outcomes, genetic variants associated with instrumental variables. The main analysis was performed using...
Drought is a major threat to agriculture production worldwide. Mitogen-activated protein kinases (MAPKs) play pivotal role in sensing and converting stress signals into appropriate responses so that plants can adapt survive. To examine the function of MAPKs drought tolerance tomato plants, we silenced SpMPK1, SpMPK2, SpMPK3 genes wild-type using virus-induced gene silencing (VIGS) method. The results indicate individual or co-silencing reduced by varying degrees. Co-silencing SpMPK1 SpMPK2...
Abstract The human telomerase reverse transcriptase (hTERT) is highly expressed in a variety of tumors. transforming growth factor beta receptor type II (TGFBR2) downstream protein (TGF-β) which suppresses activity. However, the relevance survival to expression TGFBR2, hTERT or TGFBR2/hTERT has not been previously investigated cervical cancer tissues. Our study showed that patients with low level TGFBR2 were associated poor prognosis (HR = 1.704, P 0.021), but no significant between and...
Numerous host cellular factors are exploited by viruses to facilitate infection. Our previous studies and those of others have shown heat-shock protein 90 (Hsp90), a molecular chaperone, is involved in herpes simplex virus (HSV)-1 However, the function dominant Hsp90 isoform relationship between HSV-1 α genes remain unclear.Hsp90α knockdown or inhibition significantly inhibited promoter activity downregulated virion 16(VP16) expression from plasmids. The Hsp90α knockdown-induced suppression...
Human telomerase reverse transcriptase (hTERT) is a critical factor in unlimited cell proliferation and immortalization, with numerous studies demonstrating that high expression of hTERT poor prognostic various types cancer. Ubiquitin‑conjugating enzyme E2D 3 (UBE2D3) member the E2 family, participates ubiquitin proteasome pathway to regulate basic cellular activities, such as cycle control, DNA damage response, apoptosis, tumorigenesis. Our previous study initially determined downregulation...