A5100309494- Telomeres, Telomerase, and Senescence
- Acute Myeloid Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Antifungal resistance and susceptibility
- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Coronary Interventions and Diagnostics
- Colorectal Cancer Screening and Detection
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Renal cell carcinoma treatment
- Fungal Infections and Studies
- Cancer Research and Treatments
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Body Contouring and Surgery
Shanghai Children's Medical Center
2025
Shanghai Jiao Tong University
2023-2025
Beijing Tsinghua Chang Gung Hospital
2024-2025
Tsinghua University
2024-2025
Ningxia Medical University
2025
Icahn School of Medicine at Mount Sinai
2025
Guangzhou Medical University
2022-2025
First Affiliated Hospital of Guangzhou Medical University
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2025
South China Normal University
2025
Accurate stratification of recurrence risk for bladder cancer (BCa) is essential precise individualized therapy. This study aimed to develop and validate a model predicting the in BCa patients postoperatively using 3-phase enhanced CT images.We retrospectively enrolled 874 across four centers between January 2006 December 2021. Patients from one center were used as training set, while remaining went into validation set. We trained deep learning (DL) based on convolutional neural networks...
Spinal infections, notably those induced by Aspergillus flavus ( A. ), represent a complex and uncommon clinical challenge. In individuals with diabetes mellitus, the risk is exacerbated due to compromised immune response heightened vulnerability non-standard pathogens. This case report chronicles intricate diagnostic treatment journey of 59-year-old diabetic patient grappling spinal infection attributed . The diagnosis was delayed non-specific symptoms unclear radiological signs....
Abstract The human telomerase reverse transcriptase (hTERT) is highly expressed in a variety of tumors. transforming growth factor beta receptor type II (TGFBR2) downstream protein (TGF-β) which suppresses activity. However, the relevance survival to expression TGFBR2, hTERT or TGFBR2/hTERT has not been previously investigated cervical cancer tissues. Our study showed that patients with low level TGFBR2 were associated poor prognosis (HR = 1.704, P 0.021), but no significant between and...
Abstract Background Variations in medical images specific to individual scanners restrict the use of radiomics both clinical practice and research. To create reproducible generalizable radiomics‐based models for outcome prediction assessment, data harmonization is essential. Purpose This study aims investigate impact performance machine learning‐based model toward radiotherapy‐induced toxicity (early late sticky saliva xerostomia) head neck cancer (HNC) patients after radiation therapy using...
While this syndrome is associated with bicuspid aortic valve, here we report a case presenting Shone's complicated by unicuspid valve.
Ubiquitin-conjugating enzyme UBE2D3 is an important member of the ubiquitin-proteasome pathways. Our previous study showed that expression was negatively related to human telomerase reverse transcriptase (hTERT) and radioresistance in breast cancer cells. However, esophageal carcinoma, exact effects mechanisms remain unclear. This shows knockdown associated with significant increases X-rays, activity, telomere length, shelterins. knockdown-mediated a decrease spontaneous ionizing...
Abstract Blood orange (BO) is a rare red-fleshed sweet (SWO) with high anthocyanin content and associated numerous health-related benefits. Here, we reported high-quality chromosome-scale genome assembly for Neixiu (NX) BO, reaching 336.63 Mb in length contig scaffold N50 values of 30.6 Mb. Furthermore, 96% the assembled sequences were successfully anchored to 9 pseudo-chromosomes. The also revealed presence 37.87% transposon elements 7.64% tandem repeats, annotation 30,395 protein-coding...
Abstract Background The incidence of cardiovascular diseases among old individuals is on the rise with growing trend population aging. Coronary artery bypass grafting (CABG) an important treatment modality for coronary heart and increasingly employed in older adults. However, concerns arise due to poor prognosis following surgery this population. prognostic nutritional index (PNI) reflects status immune function patients. It has been previously utilized assessments other surgical procedures...
Plasma tumor-associated exosomes represent a promising source for cancer biomarkers; however, the role of long non-coding RNAs (lncRNAs) within these is not well-defined in non-small cell lung (NSCLC). We identified panel NSCLC-specific lncRNAs plasma EpCAM-specific (Epexo) through comparative analysis lncRNA profiles between Epexo and tissues. The panel's diagnostic value was firstly evaluated retrospective cohort 210 NSCLC patients 245 healthy controls, validated prospective 192 with...
ABSTRACT Bronchiectasis frequently co‐exists with chronic obstructive pulmonary disease (COPD‐bronchiectasis association [CBA]). We compared the microbiota and metabolome of bronchiectasis (BO) without airflow obstruction (BNO), COPD, CBA. determined how compositions correlated clinical characteristics exacerbations prospectively recruited outpatients BNO ( n = 104), BO 51), COPD 33), CBA 70). sampled at stead‐state exacerbation, profiled sputum via 16S rRNA sequencing liquid...
Abstract Background High‐dose‐rate brachytherapy (HDR‐BT) is an integral part of treatment for locally advanced cervical cancer, requiring accurate segmentation the high‐risk clinical target volume (HR‐CTV) and organs at risk (OARs) on post‐applicator CT (pCT) precise safe dose delivery. Manual contouring, however, time‐consuming highly variable, with challenges heightened in HDR‐BT due to complex anatomy low tissue contrast. An effective auto‐contouring solution could significantly enhance...
e16209 Background: Hepatocellular carcinoma (HCC) is an aggressive liver cancer with limited treatment options, particularly in advanced stages. Surufatinib a small-molecule tyrosine kinase inhibitor that targets VEGFR-1/2/3, FGFR-1, and CSF-1R, has dual anti-angiogenesis immune-modulating effects. It may provide new option for patients HCC. Methods: This single-arm, open-label, multi-center Phase II trial (NCT05282433) evaluated monotherapy (300 mg qd, po, q3w) as third-line Eligible had...
The known functions of telomerase in tumor cells include replenishing telomeric DNA and maintaining cell immortality. We have previously shown the existence a negative correlation between human reverse transcriptase (hTERT) radiosensitivity cells. Here we set out to elucidate molecular mechanisms underlying regulation by MCF-7 Toward this aim, yeast two-hybrid (Y2H) screening laryngeal squamous carcinoma radioresistant (Hep2R) cDNA library was first performed search for potential hTERT...
BackgroundRadiotherapy is one of the major therapeutic strategies in cancer treatment. The telomere-binding protein TPP1 an important component shelterin complex at mammalian telomeres. Our previous reports showed that expression was elevated radioresistant cells, but exact effects and mechanisms on radiosensitivity unclear. Principal FindingsIn this study, we found significantly correlated with radioresistance longer telomere length human colorectal cell lines. Moreover, overexpression...
Abstract The regulation of inflammatory response at the site injury and macrophage immunotherapy is critical for tissue repair. Chiral self‐assemblies are one most ubiquitous life cues, which closely related to biological functions, processes, even pathogenesis diseases. However, role supramolecular chiral in immune functions internal environment tissues has not been fully explored yet. Herein, 3D self‐assembling matrixes prepared regulate polarization macrophages further enhance repair...
Blood orange (Citrus sinensis L.) is a valuable source of nutrition because it enriched in anthocyanins and has high organoleptic properties. Grafting commonly used citriculture crucial effects on various phenotypes the blood orange, including its coloration, phenology, biotic abiotic resistance. Still, underlying genetics regulatory mechanisms are largely unexplored.In this study, we investigated phenotypic, metabolomic, transcriptomic profiles at eight developmental stages lido cultivar L....