A5107464072- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Radiotherapy Techniques
- Nuclear Receptors and Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Global Cancer Incidence and Screening
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Congenital Heart Disease Studies
- Breast Cancer Treatment Studies
- Neonatal and fetal brain pathology
- Ferroptosis and cancer prognosis
- Cancer survivorship and care
- Colorectal and Anal Carcinomas
- Plant Virus Research Studies
- Inflammatory Myopathies and Dermatomyositis
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Pregnancy and preeclampsia studies
- Mitochondrial Function and Pathology
- Eosinophilic Disorders and Syndromes
Second Hospital of Shandong University
2021-2025
Shenzhen University Health Science Center
2025
Sichuan University
2025
Zhongnan Hospital of Wuhan University
2014-2024
Wuhan University
2014-2024
Shenzhen University
2024
First Affiliated Hospital Zhejiang University
2023
Anhui Medical University
2023
Hubei Cancer Hospital
2016-2022
Ningbo University
2021
Ferroptosis, featuring an iron‐dependent peroxidation of lipids, is a novel form programmed cell death that may hold great potential in cancer therapy. Our study found palmitic acid (PA) inhibited colon viability vitro and vivo , conjunction with accumulation reactive oxygen species lipid peroxidation. The ferroptosis inhibitor Ferrostatin‐1 but not Z‐VAD‐FMK (a pan‐caspase inhibitor), Necrostatin‐1 potent necroptosis or CQ autophagy), rescued the phenotype induced by PA. Subsequently, we...
The authors declare no conflicts of interest. data that support the findings this study are available on request from corresponding author. Data S1. Supporting information. Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to author article.
Abstract Nuclear factor erythroid 2-related 2 (NRF2) is a transcription responsible for mounting an anti-oxidation gene expression program to counter oxidative stress. Under unstressed conditions, Kelch-like ECH-associated protein 1 (KEAP1), adaptor CUL3 E3 ubiquitin ligase, mediates NRF2 ubiquitination and degradation. We show here that the deubiquitinase USP25 directly binds KEAP1 prevents KEAP1’s own In absence of Usp25 or if DUB inhibited, downregulated stabilized, allowing cells respond...
Early diagnosis of cleft lip and palate (CLP) requires a multiplane examination, demanding high technical proficiency from radiologists. Therefore, this study aims to develop validate the first artificial intelligence (AI)-based model (CLP-Net) for fully automated multi-plane localization in three-dimensional(3D) ultrasound during trimester. This retrospective included 418 (394 normal, 24 CLP) 3D 288 pregnant woman between July 2022 October 2024 Shenzhen Guangming District People's Hospital...
Aim . To identify the population of patients with high risk distant metastasis and poor prognosis before treatment, so as to provide early intervention better treatment decision. Method 69 nonmetastatic colorectal cancer (non-mCRC) 57 metastatic CRC (mCRC) were enrolled evaluate prognostic value serum albumin (ALB), lactate (SLA), dehydrogenase (LDH) in CRC. We then followed up mCRC. The T test, Chi square Kaplan-Meier survival analysis model, Multivariate Cox proportional hazards regression...
Radiation resistance is the leading cause of radiotherapy failure in patients with cancer. Enhanced DNA damage repair main reason for cancer cells to develop radiation. Autophagy has been widely reported be linked increased genome stability and radiation resistance. Mitochondria are highly involved cell response radiotherapy. However, autophagy subtype mitophagy not studied terms stability. We have previously demonstrated that mitochondrial dysfunction tumour cells. In present study, we...
Abstract Background Chinese wheat mosaic virus (CWMV) is a severe threat to winter and transmitted by Polymyxa graminis . The mechanisms of interactions between CWMV plants are poorly understood. In this study, comparative proteomics analysis based on nanoliquid chromatography mass spectrometry (MS)/MS was conducted characterize proteomic changes in responding infection. Results total, 2751 host proteins were identified, 1496 which quantified 146 up-regulated 244 down-regulated identified as...
Non-alcoholic fatty liver disease (NAFLD) is associated with mutations in lipopolysaccharide-binding protein (
The Rho-associated serine-threonine protein kinase (ROCK) is a downstream effector of Rho GTPases that frequently activated in the epithelial to mesenchymal transition (EMT) human ovarian cancer cells. On other hand, endothelin-1 (ET-1) and its receptor endothelin A (ET(A)R) are overexpressed primary metastatic carcinoma, which suggests ET-1 promotes tumor dissemination. Hence, two carcinoma cell lines, SK-OV-3 CaOV3, were chosen study effects ET-1/ET(A)R ROCK promoting EMT We found exposure...
Abstract Introduction To establish a plasma metabolomics fingerprint spectrum for severe burn patients and to use it identify set of biomarkers that could be used clinical monitoring. Methods Twenty-one three healthy control individuals were enrolled in this study, the samples from collected nuclear magnetic resonance (NMR) measurements. The NMR spectra analyzed using principal component analysis (PCA) partial least squares (PLS) order representing changes metabolism select major biomarkers....
<i>Objective:</i> The aim of this study was to determine whether the type congenital heart disease (CHD) or function influence fetal cerebrovascular blood flow dynamics. <i>Methods:</i> Doppler velocimetry performed in umbilical artery (UA) and middle cerebral (MCA), ratio UA pulsatility index (PI) MCA PI (U/C PI) determined 45 fetuses with CHD at 20–40 weeks’ gestational age. control group consisted 275 healthy matched for Individual measurements were converted into...
Delay to diagnosis following an abnormal screening result is associated with morbidity such as anxiety, but its effect on prognosis unknown.Using data from the Somme area breast cancer programme (France), we identified 29,511 women aged 50-69 years who underwent between 1996 and 2000. We prospectively followed until completion of assessment process evaluated delay notification, treatment prognostic indicators.Women high-suspicion screens (n=976) compared those intermediate-suspicion (n=1008)...
Abstract Purpose To evaluate the clinical efficacy and safety of apatinib combined with intensity‐modulated radiation therapy (IMRT) in patients unresectable hepatocellular carcinoma (uHCC). Materials methods Open‐label, single‐arm, exploratory trial IMRT for uHCC patients. Patients aged 18–75 years adequate hematological, liver, renal functions Eastern Cooperative Oncology Group (ECOG) performance status ≤2 were enrolled this study from March 2017 to September 2020. received (biological...
Abstract Although adjuvant chemoradiotherapy has been an important part in the treatment of gastric cancer, whether or not radiation can benefit patients undergoing resection with D2 lymph node dissection remains controversial. This retrospective study aimed to evaluate role on D2‐resected cancer. A total 337 resected cancer treated at Zhongnan Hospital Wuhan University from 2004 2012 were retrospectively analyzed. Eligible divided into group ( CRT ; n = 124) and chemotherapy CT 213). The...