A5049396687- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Diet, Metabolism, and Disease
- Acute Ischemic Stroke Management
- Protein Kinase Regulation and GTPase Signaling
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Disease and Adiposity
- Parasites and Host Interactions
- COVID-19 epidemiological studies
- Graphene and Nanomaterials Applications
- Cardiovascular Function and Risk Factors
- Cancer, Stress, Anesthesia, and Immune Response
- Reproductive Biology and Fertility
- Sepsis Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
Jena University Hospital
2022-2025
First Affiliated Hospital of Anhui Medical University
2017-2025
Anhui Medical University
2017-2025
Shanxi Medical University
2025
Shanxi Fenyang Hospital
2025
Beijing Tsinghua Chang Gung Hospital
2024
Tsinghua University
2023-2024
Cangzhou Central Hospital
2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Abstract Dysfunction of invariant natural killer T (iNKT) cells in tumor microenvironment hinders their anti-tumor efficacy, and the underlying mechanisms remain unclear. Here we report that iNKT increase lipid biosynthesis after activation, is promoted by PPARγ PLZF synergically through enhancing transcription Srebf1 . Among those lipids, cholesterol required for optimal IFN-γ production from cells. Lactic acid reduces expression intratumoral consequently diminishes synthesis production....
We previously reported that astrocyte-derived proinflammatory cytokine interleukin (IL)-17A could aggravate neuronal ischemic injuries and strength autophagy both in oxygen-glucose deprivation (OGD)/reoxygenation (R)-treated neurons peri-infarct region of mice with middle cerebral artery occlusion (MCAO)/reperfusion (R)-simulated stroke. In this study, the role molecular mechanism IL-17A were further explored under condition. found exogenous addition rmIL-17A remarkably (P<0.001) decreased...
We aimed to investigate the prevalence of stroke and related vascular risk factors in adult population aged 40 years older China. conducted a prospective cross-sectional survey nationally representative sample 207323 individuals from all 31 Chinese provinces 2013. Data were used analyze by age, sex, geographical regions educational level. The age-standardized was significantly higher men than women age groups (P < 0.001). rural urban residents among both inversely associated with There...
Rationale: Graphene oxide (GO) based nanomaterials have shown potential for the diagnosis and treatment of amyloid-β (Aβ)-related diseases, mainly on Alzheimer's disease (AD). However, these limitations. How GO is beneficial to eliminate Aβ burden, its physiological function in Aβ-related still needs be investigated. Moreover, postoperative cognitive dysfunction (POCD) an common central nervous system complication, however, nanomedicine lacking. Methods: To evaluate effects levels,...
The determination of risk factors for acute respiratory distress syndrome (ARDS) patients remains a challenge. Our study aims to explore the epidemiology and affecting outcomes ARDS provide theoretical basis patients' prognosis.This retrospective included 207 admitted general intensive care unit (ICU) in Second Affiliated Hospital Harbin Medical University from Jan 1st, 2016 2017. criteria were defined according Berlin Definition, clinical data collected medical record system. mortality rate...
Autophagy allows cancer cells to respond changes in nutrient status by degrading and recycling non-essential intracellular contents.Inhibition of autophagy combined with deprivation is an effective strategy treat cancer.Pain a primary determinant poor quality life advanced patients, but there currently no satisfactory treatment.In addition, treatment does not efficiently relieve pain, may increase pain many cases.Hence, few studies focus on simultaneous therapy relief, made this situation...
Acute kidney injury (AKI) is one of the most common acute pancreatitis (AP)-associated complications that has a significant effect on AP, but factors affecting AP patients' survival rate remains unclear.To assess influences AKI in patients.A total 139 patients were included this retrospective study. Patients divided into group (n = 72) and non-AKI 67) according to occurrence AKI. Data collected from medical records hospitalized patients. Then, these data compared between two groups further...
Non-alcoholic fatty liver disease (NAFLD) is associated with mutations in lipopolysaccharide-binding protein (
<title>Abstract</title> Based on response surface methodology and composite weighting method, this study explored the effect of ethanol concentration, liquid - to solid ratio, time extraction wheatgrass dry powder. The total phenolic content(TPC), flavonoid content(TFC), DPPH・scavenging rate(DPPH・SR), A549 cell growth inhibition rate(A549 CGIR) were selected as evaluation indicators conduct comprehensive scoring(CS). Results showed optimal conditions volume fraction 39.56%, ratio 40.11mL/g,...
ABSTRACT Aging increases the susceptibility to metabolic dysfunction–associated steatotic liver disease (MASLD). Liver sinusoidal endothelial cells (LSECs) help in maintaining hepatic homeostasis, but contribution of age‐associated LSECs dysfunction MASLD is not clear. The aim this study was investigate effect aging‐associated on MASLD. Free fatty acid–treated AML12 were co‐cultured with young and etoposide‐induced senescent TSEC evaluate senescence‐associated effects lipid accumulation...
We have reported that conventional protein kinase Cγ (cPKCγ)-modulated neuron-specific autophagy improved the neurological outcome of mice following ischemic stroke through Akt-mechanistic target rapamycin (mTOR) pathway. However, its detailed molecular mechanism remains unclear. In this study, primary cortical neurons from postnatal one-day-old C57BL/6J cPKCγ wild-type (cPKCγ+/+) and knockout (cPKCγ−/−) suffering oxygen glucose...
Interleukin (IL)-17A was reported to be involved in the development of post-ischemic stroke inflammatory response and functional recovery. However, IL-17A dynamic changes serum/cerebrospinal fluid (CSF) its role neuronal injury following ischemic are unclear.In vivo induced by 1 h middle cerebral artery occlusion (MCAO) 6 h-7 d reperfusion (R) mice, while vitro oxygen-glucose deprivation (OGD)/24 reoxygenation cultured cortical neurons. Enzyme-linked immunosorbent assay (ELISA)...
Background: Schistosomiasis is one of the most devastating tropical diseases in world. Oncomelania hupensis only intermediate host Schistosoma japonicum, and its growth development are sensitive to environmental factors. The Three Gorges Dam has substantially altered water level Yangtze River. This study focused on impact flooding time occurrence snails Hunan Province, China. Methods: data regarding were collected from Atlas People’s Republic Air temperature, hours daylight relative humidity...
We previously reported that astrocytes are the main sources of interleukin (IL)-17A production could aggravate neuronal injuries in ischemic stroke. However, effects IL-17A on themselves and underlying molecular mechanism still unclear. In this study, we found recombinant mouse (rm) significantly (P < 0.05 or <0.001) alleviate 1-hour oxygen-glucose deprivation (OGD)/reoxygenation (R) 24-hour-induced cortical with a dose-dependent manner (n = 6 per group). The Western blot cell cycle analysis...
Summary The hyperactivation of human spermatozoa necessary for fertilization requires a substantial increase in cellular energy production. factors responsible increasing remain poorly defined. This article proposes role novel mitochondrial progesterone receptor ( PR ‐M) modulation activity. Basic science studies demonstrate 38 kDa protein with western blot analysis, consistent ‐M; whereas imaging confocal and immunoelectron microscopy on the mitochondria. Treatment ‐specific progestin shows...
Schistosomiasis remains a major public health concern in China. Oncomelania hupensis (O. hupensis) is the sole intermediate host of Schistosoma japonicum, and its change distribution density influences endemic S. japonicum. The Three Gorges Dam (TGD) has substantially changed downstream water levels dam. This study investigated quantitative relationship between flooding duration snail population. Two bottomlands without any control measures for snails were selected Yueyang City, Hunan...
To investigate the right heart function in coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome (ARDS), a retrospective analysis of 49 COVID-19 ARDS was performed. Patients were divided into severe group and critically-severe according to severity illness. Age-matched healthy volunteers recruited as control group. The cardiac cavity diameters, tricuspid annular plane systolic excursion (TAPSE), valve regurgitation pressure gradient biggest (TRPG), pulmonary...
Aging increases the susceptibility to chronic liver diseases and hastens fibrosis deterioration, but underlying mechanisms remain partially understood. The aim of this study was investigate effect aging on hepatocyte Sirtuin 1 (SIRT1) LSECs their contribution pathogeneses.
Introduction Cerebral ischaemia-induced depression is among the most frequent neuropsychiatric consequences and adversely impact prognosis recovery of patients. Although several brain regions have been implied in development depression, region-specific neural cell apoptosis pathways not clarified yet. Methods In this study, bilateral internal carotid artery occlusion (BICAO) mouse model was established to induce cerebral ischaemia. Sucrose preference, tail suspension forced swim tests were...
Background: The purpose of this study was to evaluate known and yet unknown risk factors associated with readmission the hospital within 30 days after hip fracture. Methods: In study, we used Cerner Health Facts Electronic Record database data from January August 2015. univariate association each variable (discharge location, demographic details, comorbidities) against 30-day status evaluated using Chi-square test or Fisher exact test. significant variables ( P < 0.05) obtained by...