A5008901556- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Phagocytosis and Immune Regulation
- ZnO doping and properties
- Ga2O3 and related materials
- Electronic and Structural Properties of Oxides
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Pancreatic function and diabetes
- Spectroscopy and Quantum Chemical Studies
- Photoreceptor and optogenetics research
- Bladder and Urothelial Cancer Treatments
- Autoimmune and Inflammatory Disorders Research
- Pregnancy-related medical research
- Radiation Effects in Electronics
- Macrophage Migration Inhibitory Factor
- Microbial Applications in Construction Materials
- Inflammasome and immune disorders
- Pregnancy and preeclampsia studies
- Immune responses and vaccinations
- Adenosine and Purinergic Signaling
- Advanced Breast Cancer Therapies
- interferon and immune responses
University of Science and Technology of China
2019-2025
Harbin Medical University
2023-2024
Hefei National Center for Physical Sciences at Nanoscale
2024
Fourth Affiliated Hospital of Harbin Medical University
2023-2024
Shanghai Jiao Tong University
2024
Renji Hospital
2024
Taian City Central Hospital
2022
Qingdao University
2022
Czech Academy of Sciences, Institute of Biophysics
2022
Chinese Academy of Sciences
2021-2022
Abstract Dysfunction of invariant natural killer T (iNKT) cells in tumor microenvironment hinders their anti-tumor efficacy, and the underlying mechanisms remain unclear. Here we report that iNKT increase lipid biosynthesis after activation, is promoted by PPARγ PLZF synergically through enhancing transcription Srebf1 . Among those lipids, cholesterol required for optimal IFN-γ production from cells. Lactic acid reduces expression intratumoral consequently diminishes synthesis production....
Abstract Detecting high‐energy photons from the deep ultraviolet (DUV) to X‐rays is vital in security, medicine, industry, and science. Wide bandgap (WBG) semiconductors exhibit great potential for detecting photons. However, implementation of highly sensitive high‐speed detectors based on WBG has been a huge challenge due inevitable level traps lack appropriate device structure engineering. Here, fast pyroelectric photoconductive diode (PPD), which couples interface effect with tailored...
Mounting evidence has revealed that impaired spiral artery remodeling, placental dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology pathogenesis of pre-eclampsia (PE). Moreover, defective may trigger poor maternal-fetal circulation hypoxia, leading to PE. However, detailed molecular pathology PE remains unclear. Although circRNAs, as a new type stable abundant endogenous noncoding RNA, have been proven be essential various diseases, their role in...
Activation of NLRP3 inflammasome is precisely controlled to avoid excessive activation. Although multiple molecules regulating activation have been revealed, the checkpoints governing remain elusive. Here, we show that governed by GSTO1-promoted ASC deglutathionylation in macrophages. Glutathionylation inhibits oligomerization and thus represses macrophages, unless GSTO1 binds deglutathionylates at ER, under control mitochondrial ROS triacylglyceride synthesis. In macrophages expressing...
Abstract Sensitive high‐energy photon detection from UV to X‐ray and high‐resolution array imaging are critical for medical diagnosis, space exploration, scientific research. The key challenges high‐performance photodetector arrays the effective material device design strategies miniaturization integration of device. Here, photon‐controlled diodes (i.e., detector has rectifying characteristics only under light irradiation) proposed anti‐crosstalk applications without integrating switching...
Abstract Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characteristic for antigen scanning and thus anti-tumor capability. Here we show via intravital imaging, that impaired iNKT exclusion from tumors both contribute the diminished cell response. Mechanistically, CD1d, expressed macrophages, interferes with...
The electric field sensed by molecules in nanocavities determines the molecular vibrational energy relaxation dynamics using ultrafast time-resolved sum frequency generation spectroscopy.
Abstract The development of high‐performance detectors has played a key role in the innovation modern optoelectronics. However, implementation been huge challenge, especially present with only optoelectronic conversion functions cannot satisfy growing demands multifunction required single devices. Here, it is demonstrated novel in‐memory photodetector based on wide bandgap semiconductor Ga 2 O 3 by integrating memory characteristics into detector. Originating from dynamic control channel...
Invariant natural killer T (iNKT) cells are innate-like lymphocytes that express an invariant cell receptor (TCR), which recognizes glycolipid antigens presented on CD1d molecules. These phenotypically and functionally distinct from conventional cells. When we characterized the metabolic activity of iNKT cells, consistent with their activated phenotype, found they had much less mitochondrial respiratory capacity but increased glycolytic in comparison to naïve CD4+ After TCR engagement,...
Activation of mTORC1 is essential for anti-tumor function iNKT cells. The mechanisms underlying impaired activation in intratumoral cells remain unclear. Via generating Vam6 +/- mice and using flow cytometry, image approach, RNA sequencing, we studied the role controlling cell functions. Here, find that increased expression leads to IFN-γ production. Mechanistically, Rab7a-Vam6-AMPK complex formation thus recruitment AMPK lysosome activate AMPK, a negative regulator mTORC1. Additionally,...
Protein misfolding and amyloid formation are implicated in the protein dysfunction, but underlying mechanism remains to be clarified due lack of effective tools for detecting transient intermediates. Sum frequency generation vibrational spectroscopy (SFG-VS) has emerged as a powerful tool identifying structure dynamics proteins at interfaces. In this review, we summarize recent SFG-VS studies on membrane-bound during processes. This paper first introduces methods determining secondary...
High-performance radiation detectors are essential in many sectors spanning medical diagnostics, nuclear control, and particle physics. Ultrawide bandgap semiconductor materials have become one of the most promising candidates due to their excellent performance. Here, based on β-Ga2O3, a Schottky diode-type alpha detector was demonstrated. In order reduce reverse leakage current large-area device, metal-oxide electrode PtOx introduced form high-barrier contacts (1.83 eV) with Ga2O3. The...
Ga2O3 has been considered as one of the most suitable materials for x-ray detection, but its detection performance is still at a low level due to limitation quality and absorbance, especially hard x-ray. In this work, effects growth temperature miscut angle sapphire substrate on crystal thin films were investigated based MOCVD technique. It was found that mode transformed from island step-flow using substrates increasing temperature, which accompanied by improvement reduction density trapped...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a variety of clinical manifestations, many which originate from altered immune responses, either locally or systemically. Immune cell cross-talk occurs mainly in lymphoid organs. However, systemic interaction specific to disease 2019 has not been well characterized. Here, by employing single-cell RNA sequencing and imaging flow cytometry analysis, we unraveled, peripheral blood, heterogeneous group complexes formed...
CD8+ invariant natural killer T (iNKT) cells are functionally different from other iNKT and enriched in human but not mouse. To date, their developmental pathway molecular basis for fate decision remain unclear. Here, we report enrichment of neonatal mice due to more rapid maturation kinetics than CD8- cells. Along trajectories, separate at stage 0, following 0 double-positive cells, differ HIVEP3 expression. is lowly expressed negatively controls development, whereas it highly positively...
Significance Invariant natural killer T (iNKT) cells participate in the first line of body defense and can be classified into three functional subsets. Differences their developmental control further contribute to complexity. Here, we show that Foxo1 promotes survival iNKT1 iNKT2 at early stages differentiation but is dispensable for iNKT17 cell development due its distinct contributions IL7R expression these Additionally, required mTORC1 activation function through inhibiting TSC1–TSC2...
Dysfunction of intratumoral invariant natural killer T (iNKT) cells hinders their antitumor efficacy, but the underlying mechanisms and relationship with endogenous antigen priming remain to be explored. Here, we report that leads metabolic reprogramming epigenetic remodeling, which causes functional in iNKT cells, characterized by limited cytokine responses upon restimulation constitutive high cytotoxicity. Mechanistically, impaired oxidative phosphorylation (OXPHOS) antigen-primed...
<p>Antigen priming leads to dysfunction in distinct iNKT subsets.</p>
<p>A, Procedure for TCR signaling priming of human iNKT cells in vitro. B, The TMRM/MitoTracker ratio (n = 4) control and signaling-primed cells, the presence ZLN005 or DMSO as control. C, Frequencies IFN+ GzmB+ after restimulation with anti-CD3 plus anti-CD28 antibodies indicated (A) 7). Data are represented mean ± SD. Student’s t test was used to determine statistical significance (*P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, n.s., not significant).</p>