A5026627325- Clinical Nutrition and Gastroenterology
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Seaweed-derived Bioactive Compounds
- Electrolyte and hormonal disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Lipid metabolism and disorders
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
Nanjing General Hospital of Nanjing Military Command
2020-2025
Wenzhou Medical University
2014-2025
Ningbo University
2016-2025
Nanjing University
2006-2025
Zhongshan Hospital
2016-2025
Shanghai Children's Medical Center
2024-2025
Fujian Medical University
2022-2025
Fudan University
2016-2025
Fujian Provincial Cancer Hospital
2024
Xiamen University
2023-2024
Fucoxanthin, a natural carotenoid abundant in edible brown seaweeds, has been shown to possess anti-cancer, anti-oxidant, anti-obesity and anti-diabetic effects. In this study, we report for the first time that fucoxanthin effectively protects against scopolamine-induced cognitive impairments mice. addition, significantly reversed increase of acetylcholinesterase (AChE) activity decreased both choline acetyltransferase brain-derived neurotrophic factor (BDNF) expression. Using an vitro AChE...
β-Amyloid (Aβ) can form aggregates through self-assembly and produce neurotoxicity in the early stage of Alzheimer's disease (AD). Therefore, inhibition Aβ assembly is considered as primary target for AD therapy. In this study, we reported that fucoxanthin, a marine carotenoid, potently reduced formation fibrils oligomers. Moreover, fucoxanthin-triggered modification significantly oligomers vitro. Molecular dynamics simulation analysis further revealed hydrophobic interaction between...
<h3>Background</h3> Intrahepatic cholangiocarcinoma (ICC) is a highly mortal malignancy with limited therapeutic options. Immunotherapies targeting PD-1/PD-L1 pathway represent promising treatment for ICC. However, PD-L1 expression and microsatellite instability are not common in This study aimed to investigate whether HHLA2, newly identified B7 family immune checkpoint T cells, could be target next <h3>Methods</h3> Expression levels of HHLA2 as well infiltrations CD3+, CD8+, CD4 + Foxp3+,...
The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits unclear.To assess the association between plasmapheresis and duration organ failure among patients with HTG-AP.This an a priori analysis data multicenter, prospective cohort study enrolled 28 sites across China. Patients HTG-AP were admitted within 72 hours disease onset. first patient...
Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by neurofibrillary tangles, synaptic impairments, and loss of neurons. Oligomers β-amyloid (Aβ) are widely accepted as main neurotoxins to induce oxidative stress neuronal in AD. In this study, we discovered that fucoxanthin, a marine carotenoid with antioxidative properties, concentration dependently prevented Aβ oligomer-induced increase apoptosis intracellular reactive oxygen species SH-SY5Y cells....
Background: As a natural carotenoid abundant in chloroplasts of edible brown algae, fucoxanthin possesses various health benefits, including anti-oxidative activity particular. Objective: In the present study, we studied whether protected against hydrogen peroxide (H2O2)-induced neuronal apoptosis. Design: The neuroprotective effects on H2O2-induced toxicity were both SH-SY5Y cells and primary cerebellar granule neurons. Results: Fucoxanthin significantly apoptosis intracellular reactive...
Abstract Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain effects guideline implementation on patient-centered outcomes. Methods We conducted a multicenter, cluster-randomized, parallel-controlled trial intensive care units (ICUs) across China. developed...
Abstract Transient receptor potential vanilloid 1 (TRPV1) ion channel is a classic analgesic target, but antagonists of TRPV1 failed in clinical trials due to their side effects like hyperthermia. Here we rationally engineer peptide s-RhTx as positive allosteric modulator (PAM) TRPV1. Patch-clamp recordings demonstrate selectively potentiated activation. also slows down capsaicin-induced desensitization the presence calcium cause more influx TRPV1-expressing cells. In addition, our...
Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, generally regarded as main neurotoxin in disease. Here we report eckmaxol, phlorotannin extracted from brown alga Ecklonia maxima, could produce neuroprotective effects SH-SY5Y cells. Eckmaxol effectively prevented but did not rescue oligomer-induced neuronal apoptosis and increase of intracellular reactive oxygen species. also...
β-Cypermethrin (β-CYP), one of most important pyrethroids, is widely used to control insects, and has been detected in organisms, including human. Pyrethroids have shown pose neurotoxicity, hepatotoxicity, endocrine disruption reproductive risks mammals. However, research immunotoxicity especially their metabolites, limited. A common metabolite pyrethroids 3-phenoxybenzoic acid (3-PBA) Thus, this study, we evaluated the β-CYP 3-PBA mouse macrophages, RAW 264.7 cells. MTT assays showed that...
Gastric cancer which starts from the stomach is a fatal with poor prognosis around world. The recurrence and metastasis of gastric may be attributed to stem cells. It recognized that usually possesses multiple populations distinct cells different phenotypes, thus it will imperative target more subsets instead targeting only one population generally accepted both CD44 CD133 are markers, we hereby developed CD44/CD133-ATRA-PLPN (CD44 antibody-conjugated all-trans retinoic acid-loaded...
Abstract Objective To examine the role of high‐fat and high‐sugar (HFHS) diet‐induced oxidative stress, which is a risk factor for various diseases, in premature ovarian failure (POF). Materials methods Ovarian granulosa cells (OGCs) were isolated from mice cultured medium supplemented with HFHS poly (lactic‐co‐glycolic acid) (PLGA)‐cross‐linked miR‐146b‐5p nanoparticles (miR‐146@PLGA). RNA protein expression levels examined using quantitative real‐time polymerase chain reaction Western...
Human ovarian cancer stem cells (HuOCSCs) are the main source of recurrence, metastasis, and drug resistance. Superparamagnetic iron oxide nanoparticles (SPIONs) well-known nucleic acid or carriers owing to their controllable properties, superior stability, easy modification. However, whether SPIONs can inhibit activity HuOCSCs by inducing ferroptosis remains unclear. In present study, we isolated CD44 + /CD133 from tumours four patients with clear cell added 0.2 mM for mixed culture....
No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack quality evidence. This study aimed to describe practice variations therapies for early HTG-AP and assess whether more rapid triglyceride decline associated improving organ failure. a multicentre, prospective cohort recruiting elevated plasma (> 11.3 mmol/L) admitted within 72 h from onset symptoms. Patients were dichotomised on...
Sunitinib, a tyrosine kinase inhibitor, is clinically used for the treatment of cancer. In this study, we found first time that sunitinib inhibits acetylcholinesterase (AChE) at submicromolar concentrations in vitro. addition, dramatically decreased hippocampal and cortical activity AChE time-dependent manner mice. Molecular docking analysis further demonstrates might interact with both catalytic anion peripheral anionic sites within AChE, which accordance enzymatic results showing mixed...
// Chu-Yu Jing 1, * , Yi-Peng Fu Hu-Jia Shen Su-Su Zheng 1 Jia-Jia Lin Yong Yi Jin-Long Huang Xin Xu Juan Zhang Jian Zhou Jia Fan Zheng-Gang Ren Shuang-Jian Qiu Bo-Heng The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis Invasion, Chinese Ministry of Education, Shanghai, P.R. China. These authors have contributed equally to this work Correspondence to: Zhang, email: zhang.boheng@zs-hospital.sh.cn Keywords: albumin,...
The Klebsiella pneumoniae (K. pneumoniae, Kp) populations carrying both resistance-encoding and virulence-encoding mobile genetic elements (MGEs) significantly threaten global health. In this study, we identified a new anti-CRISPR gene (acrIE10) on conjugative plasmid with self-target sequence in K. type I-E* CRISPR-Cas system. AcrIE10 interacts the Cas7* subunit of crystal structure AcrIE10-KpCas7* complex suggests that suppresses by binding directly to Cas7 prevent its hexamerization,...
RNA-binding proteins (RBPs) refer to a class of that participate in alternative splicing, RNA stability, polyadenylation, localization and translation RNAs, thus regulating gene expression post-transcriptional manner. Dysregulation RNA-RBP interaction contributes various diseases, including cancer. In breast cancer, disorders RBP function influence the biological characteristics tumor cells. Targeting RBPs has fostered development innovative therapies for However, RBP-related mechanisms...
Abstract Background Malnutrition due to interruption of enteral nutrition remains a prevalent issue in the intensive care unit (ICU). Aim This study aimed determine frequency and causes (ENI)and its impact on implementing nutrition. Study Design is secondary analysis multicentre, cluster‐randomized controlled trial ( N = 2772). included patients ICU for at least 72 h receiving total The ENI were defined as (1) feeding intolerance, (2) diagnostic therapeutic procedures (3) others. Multiple...