A5026863190- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Aortic aneurysm repair treatments
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- Galectins and Cancer Biology
- Liver physiology and pathology
- Hormonal Regulation and Hypertension
- Lung Cancer Treatments and Mutations
- Air Quality and Health Impacts
- Cancer Diagnosis and Treatment
- Birth, Development, and Health
Wuhan University
2015-2025
Zhongnan Hospital of Wuhan University
2022-2025
Anhui Medical University
2025
Union Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
Medical University of South Carolina
2014-2024
Peking University
2018-2024
Zhejiang Marine Fisheries Research Institute
2024
Peking University Third Hospital
2024
Linyi People's Hospital
2006-2024
Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, product of follicular helper CD4+T cells (TFH) and contributor to tertiary lymphoid structures (TLS). Although secretion function CXCL13 produced by TFH have been deeply explored, the immune prognostic significance secreted CD8+T still remain unrevealed. This study aims investigate clinical merit CXCL13+CD8+T in clear cell renal carcinoma (ccRCC).We analyzed value contexture that associated with...
T-cell immunoglobulin and ITIM domain (TIGIT) is identified as a novel checkpoint receptor that can facilitate immune escape via mediating exhaustion in tumors. However, the clinical significance contexture correlation of intratumoral TIGIT+ CD8+ T-cells remain to be further explored muscle-invasive bladder cancer (MIBC).259 patients with MIBC from two centers (Zhongshan Hospital, n=141; Shanghai Cancer Center, n=118) were analyzed evaluate prognostic value association through...
Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of head and neck cancer with frequent recurrence poor survival. Immunotherapy has demonstrated efficacy in recurrent/metastatic cancer. However, whether antitumor responses could be fostered by neoadjuvant presurgical immunotherapy remains unclear. Using Simon's two-stage design, we present results single-arm phase-II trial where 12 patients stage II-IVA OCSCC received 3 to 4 biweekly doses mg/kg nivolumab...
Abstract Background Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There an urgent need development of both early therapeutic intervention AD. Results Herein, we developed a nanotheranostics platform consisting Curcumin (Cur), anti-inflammatory molecule, superparamagnetic iron oxide (SPIO) nanoparticles encapsulated by diblock 1,2-dio-leoyl- sn -glycero-3-phosphoethanolamine- n...
Fibrotic hypersensitivity pneumonitis (FHP) remains one of fatal interstitial pulmonary disease. Comprehensively dissecting the cellular heterogeneity FHP paves way for developing general gene therapeutic solutions FHP. Here, utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis profiles, we identified ten major cell types 19 unique subtypes. exhibited higher features EMT inflammation-promoting than normal control. In distinct subsets lung macrophages in...
Fine particulate matter 2.5 (PM2.5) exposure leads to the progress of pulmonary disease. It has been reported that N6-methyladenosine (m6A) modification was involved in various biological processes and diseases. However, critical role m6A disease during PM2.5 remains elusive. Here, we revealed lung inflammation mucus production caused by were associated with modification. Both vivo vitro assays demonstrated elevated total level as well methyltransferase like 3 (METTL3) expression....
Cisplatin is one of the most active cytotoxic agents for non-small cell lung cancer (NSCLC) treatment. However, development cisplatin resistance common. Bu-Zhong-Yi-Qi decoction (BZYQD), a Chinese traditional herbal medicine, widely used enhancement antitumor effect in other medications. In this study, we evaluated and drug-resistance reversal mechanism BZYQD combined with on cisplatin-resistant A549/DDP cells. Our results showed that exhibited direct chemosensitizing effects. Cotreatment...
MET, the receptor for hepatocyte growth factor (HGF), plays an important role in signaling normal and tumor cell migration invasion. Here, we describe a previously unrecognized mechanism that promotes MET expression multiple types. The levels of Pim-1 protein kinase show positive correlation with human lines patient-derived materials. Using small interfering RNA (siRNA), Pim knockout mice, small-molecule inhibitors, overexpression Pim-1, confirmed this found activity regulates HGF-induced...
Intestinal mucositis is a serious toxic side effect of 5-fluorouracil (5-FU) treatment. Bu-Zhong-Yi-Qi decoction (BZYQD), water extract Chinese traditional herbal medicine, widely used in chemotherapy Asia as an alternative treatment to reduce the effects chemotherapy. However, mechanism unknown. To evaluate its mechanism, we investigated BZYQD on 5-FU-induced intestinal mice, especially with regard apoptosis mucosal epithelia. In present study, mice were divided into three groups: control,...
The objective response rate (ORR) of tyrosine kinase inhibitors (TKIs) therapy in metastatic renal cell cancer (mRCC) patients was not satisfactory. Effective indicator mRCC patient selection for TKI is urgently needed. function tumor infiltrating B lymphocytes (TIBs) immune elimination still unclear. We aim to investigate the prognostic and predictive value TIBs this study. 108 eligible treated with were enrolled estimated by immunohistochemical staining CD19 resected tumor, its...
Mutations of SETD2 occur in 3% to 16% clear cell renal carcinoma cases. Previous studies identified an association between mutation and prognosis patients with nonmetastatic carcinoma. In this study we explored the prognostic predictive value expression metastatic treated targeted therapy.We retrospectively enrolled 138 sunitinib or sorafenib at a single institution from 2007 2014. was assessed by immunohistochemistry on tissue microarrays.After excluding those loss followup unavailable...
Background Increasing evidence has elucidated the clinical significance of tumor infiltrating immune cells in predicting outcomes and therapeutic efficacy. In this study, we comprehensively analyze microenvironment (TME) cell infiltrations clear renal carcinoma (ccRCC) correlated infiltration patterns with anti-tumor immunity outcomes. Methods We analyzed four independent cohorts, including KIRC cohort 533 patients, Zhongshan ccRCC cohorts 259 fresh sample 20 patients metastatic 87 patients....
Human ovarian cancer stem cells (HuOCSCs) are the main source of recurrence, metastasis, and drug resistance. Superparamagnetic iron oxide nanoparticles (SPIONs) well-known nucleic acid or carriers owing to their controllable properties, superior stability, easy modification. However, whether SPIONs can inhibit activity HuOCSCs by inducing ferroptosis remains unclear. In present study, we isolated CD44 + /CD133 from tumours four patients with clear cell added 0.2 mM for mixed culture....
A new therapy strategy for relapsing patients who have received trastuzumab treatment urgently needs to be explored. HER2-specific chimeric antigen receptor (CAR)-expressing NK cells are being rapidly developed solid tumor therapy, as they many advantages over HER2-CAR-T cells. Endogenous soluble PD-1 (sPD-1) from the extracellular domain blocks PD-1/PD-L1 interaction promote cancer immunology. Herein, we engineered a HER2-CAR-NK cell that co-expresses sPD-1 (designed sPD-1-CAR-NK cells) and...
Recent studies have reported that the presence of cancer stem cells (CSCs) has major implications in treatment and is responsible for tumor relapse. In current study, we identified characterized colon CSC-like side population (SP) from tissue.The samples were subjected to fluorescence-activated cell sorting (FACS) based on Hoechst 33342 dye exclusion purification SP cells. The sorted further characterization by immunofluorescence, real-time polymerase chain reaction (RT-PCR), multidrug...
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide, both cardiac necroptosis endoplasmic reticulum stress (ERS) have been involved in the pathophysiology AMI. ZYZ-803 hybrid molecule dual donor for gasotransmitters H 2 S NO. The aim present study to investigate antinecroptosis role potential mechanisms setting ERS during AMI injury. In vivo , preserves function reduces infarct size significantly after 24-hour left coronary artery ligation through...