A5020007262- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Lipoproteins and Cardiovascular Health
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Mycobacterium research and diagnosis
- Spine and Intervertebral Disc Pathology
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Diagnosis and treatment of tuberculosis
- Renal Diseases and Glomerulopathies
- Coronary Interventions and Diagnostics
- Chemokine receptors and signaling
- Head and Neck Cancer Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Immune cells in cancer
Chengdu University of Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Peking Union Medical College Hospital
2023-2025
Tianjin Medical University Cancer Institute and Hospital
2017-2024
Qingdao University
2022-2023
Affiliated Hospital of Qingdao University
2022-2023
Sun Yat-sen University
2016-2022
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Fudan University
2016-2021
Zhongshan Hospital
2016-2021
Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, product of follicular helper CD4+T cells (TFH) and contributor to tertiary lymphoid structures (TLS). Although secretion function CXCL13 produced by TFH have been deeply explored, the immune prognostic significance secreted CD8+T still remain unrevealed. This study aims investigate clinical merit CXCL13+CD8+T in clear cell renal carcinoma (ccRCC).We analyzed value contexture that associated with...
T-cell immunoglobulin and ITIM domain (TIGIT) is identified as a novel checkpoint receptor that can facilitate immune escape via mediating exhaustion in tumors. However, the clinical significance contexture correlation of intratumoral TIGIT+ CD8+ T-cells remain to be further explored muscle-invasive bladder cancer (MIBC).259 patients with MIBC from two centers (Zhongshan Hospital, n=141; Shanghai Cancer Center, n=118) were analyzed evaluate prognostic value association through...
TNFR2+ regulatory T cells preferentially accumulate in the tumor microenvironment, express high levels of immunosuppressive molecules and possess strong suppressive activity. Our study aimed to explore characteristics role Tregs microenvironment progression gastric cancer via polychromatic immunofluorescence, single-cell RNA sequencing flow cytometry assays. The Treg infiltration level increased significantly as progressed was demonstrated be a prognostic marker. Single-cell revealed TNFR2...
The objective response rate (ORR) of tyrosine kinase inhibitors (TKIs) therapy in metastatic renal cell cancer (mRCC) patients was not satisfactory. Effective indicator mRCC patient selection for TKI is urgently needed. function tumor infiltrating B lymphocytes (TIBs) immune elimination still unclear. We aim to investigate the prognostic and predictive value TIBs this study. 108 eligible treated with were enrolled estimated by immunohistochemical staining CD19 resected tumor, its...
Mutations of SETD2 occur in 3% to 16% clear cell renal carcinoma cases. Previous studies identified an association between mutation and prognosis patients with nonmetastatic carcinoma. In this study we explored the prognostic predictive value expression metastatic treated targeted therapy.We retrospectively enrolled 138 sunitinib or sorafenib at a single institution from 2007 2014. was assessed by immunohistochemistry on tissue microarrays.After excluding those loss followup unavailable...
<b><i>Objectives:</i></b> We explored whether preoperative rosuvastatin could protect the cardiac health of patients with coronary artery disease undergoing emergency, noncardiac surgery. <b><i>Methods:</i></b> randomized 550 emergency surgery stable on long-term statin therapy to treatment and without rosuvastatin. All received after evaluated incidence myocardial necrosis major adverse cardiovascular cerebrovascular events (MACCE) 30 days 6...
Objectives Tumor necrosis receptor super family (TNFRSF) plays an important role in regulating the function of CD8+ T cells. In this study, we explored clinical significance and immune profile TNFRSF9+ cells clear cell renal carcinoma (ccRCC)Methods The infiltration was determined by immunohistochemistry ZS cohort from our hospital their prognostic value further Cox regression. Functional status ccRCC flow cytometry 29 fresh tumor samples. silico analysis on a TCGA other datasets performed...
As a key energy resource, oil is not only the cornerstone of industrial development and an important support for economic growth, but also indispensable part maintenance security, so accurate prediction prices vital significance. Many uncertainties bring challenges to current WTI price forecasting, this paper proposes four-stage preprocessing model random forest (RF), multivariate variational modal decomposition (MVMD), empirical (MEMD), fuzzy entropy (FE), bidirectional gated recurrent unit...
The present study examined whether atorvastatin, when used for pharmacological postconditioning, attenuated myocardial ischemia-reperfusion (I/R) injury in a manner similar to ischemic postconditioning (I-PostC), that is, by inhibition of endoplasmic reticulum (ER) stress–related apoptosis. In the study, markers injury, infarct area, and hemodynamics, indicators ER stress apoptosis were compared atorvastatin-induced as means evaluating protective effect atorvastatin I/R whether, I-PostC, is...
// Wei Xi 1, * , Li Liu Jiajun Wang Yu Xia 1 Qi Bai Ying Xiong Yang Qu Qilai Long Jiejie Xu 2 Jianming Guo Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Biochemistry and Molecular Biology, School Basic Medical Sciences, These authors contributed equally to this work Correspondence to: Xu, email: jjxufdu@fudan.edu.cn Guo, guo.jianming@zs-hospital.sh.cn Keywords: ccRCC, C5aR, C5a-C5aR axis, prognosis, nomogram Received: September 20,...
// Yang Qu 1, * , Li Liu Jiajun Wang Wei Xi 1 Yu Xia Qi Bai Ying Xiong Qilai Long Jiejie Xu 2 Jianming Guo Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Biochemistry and Molecular Biology, School Basic Medical Sciences, These authors have contributed equally to this work Correspondence to: Xu, email: jjxufdu@fudan.edu.cn Guo, guo.jianming@zs-hospital.sh.cn Keywords: clear-cell renal cell carcinoma, Dot1l, overall survival, prognostic biomarker, nomogram...
Intervertebral disc degeneration (IDD) is a chronic degenerative and age-dependent process characterized by aberrant apoptosis, proliferation, synthesis, catabolism of the extracellular matrix nucleus pulposus (NP) cells. Recently, studies showed that circular RNAs play important roles in development many diseases. However, role circRNAs IDD remains unknown. We circ_0134111 level was overexpressed tissue samples as compar-ed to control tissues. The upregulation more drastic moderate severe...
This study was designed to investigate whether patients with stable coronary artery disease (CAD) receiving chronic statin treatment who are undergoing noncardiac emergency surgery benefit from acute atorvastatin reload.A total of 500 CAD and regular administration before were randomized reload (n = 250) or placebo 250). All received thereafter. The primary end point a 30-day incidence major adverse cardiac events (MACE). Secondary points the atrial fibrillation (AF) during hospitalization...
Primary pulmonary mucinous adenocarcinoma (PPMA) is one of the important subtypes lung adenocarcinoma. Detection anaplastic lymphoma receptor tyrosine kinase (ALK) rearrangements and KRAS epidermal growth factor (EGFR) mutations will help in diagnosing predicting treatment outcome. The aim this study was to investigate clinicopathological significance ALK rearrangements, EGFR PPMA. expression detected immunohistochemically. were determined by amplification refractory mutation system....
A pathological examination plays an important role in the confirmation of a diagnosis tuberculosis, especially for smear- and culture-negative cases. However, conventional Ziehl-Neelsen staining histological tests lack sensitivity specificity.To evaluate diagnostic value immunohistochemical to detect Mycobacterium tuberculosis protein Ag85B newly developed double (ZC staining) method that can simultaneously acid-fast bacilli M. antigen same section.A total 282 formalin-fixed...
Tumor-infiltrating neutrophils (TINs) show diverse predictive effects in the context of different cancer types and therapeutic regimens. In this study we investigated their relevance with effect tyrosine kinase inhibitors (TKIs) metastatic renal cell carcinoma (mRCC). Two independent datasets including 271 mRCC patients treated by TKIs or IL-2/IFN-α based immunotherapy were retrospective included, TINs detected immunohistochemistry. The presence was observed 50 (45.0%) samples TKI cohort 73...
Background Tumor-infiltrating regulatory T cells (TI-Tregs) are well-adapted to thrive in the challenging tumor microenvironment (TME) by undergoing metabolic reprogramming, notably shifting from glycolysis mitochondrial oxidative phosphorylation (OXPHOS) for energy production. The extracellular matrix is an important component of TME, contributing regulation both and immune cell metabolism patterns activating mechanosensors such as YAP. Whether YAP plays a part regulating TI-Treg function...
We determined whether tumor pseudocapsule status, including the extent of invasion by cancer and lack a pseudocapsule, has prognostic value in renal cell carcinoma.We retrospectively reviewed records 1,577 patients with different stages carcinoma who underwent nephrectomy at our institution, whom 1,307 (82.9%) were eligible for analysis. Presented pseudocapsules classified as grade 0-completely intact, 1-merely involved 2-penetrated. studied overall progression-free survival using...