A5014477100- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Renal and related cancers
- Advanced Graph Theory Research
- Galectins and Cancer Biology
- Graph theory and applications
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Luminescence Properties of Advanced Materials
- Glass properties and applications
- Security and Verification in Computing
- Advanced Malware Detection Techniques
- Graph Labeling and Dimension Problems
- Systemic Lupus Erythematosus Research
- Urinary and Genital Oncology Studies
- Advanced Combinatorial Mathematics
- Cloud Data Security Solutions
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Advanced Text Analysis Techniques
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
Fudan University
2016-2025
Beijing Institute of Fashion Technology
2024
Institute of Information Engineering
2016-2024
Chinese Academy of Sciences
2018-2024
Sichuan University
2016-2024
Fujian Normal University
2009-2024
Henan University Huaihe Hospital and Huaihe Clinical Institute
2024
Shanghai Medical College of Fudan University
2011-2023
University of Jinan
2016-2023
Xinjiang Normal University
2007-2022
Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, regulatory effect on immune surveillance in remains obscure. Design Flow cytometry analyses were performed to examine major source and phenotypes cells fresh tumour tissues from 76 patients with cancer. Real-time PCR was analyse mRNA level tissues. For immunohistochemical analyses, a total 420 undergoing curative resection enrolled. In...
Patients with systemic lupus erythematosus (SLE) are found to be accompanied innate immunity dysregulation including abnormally macrophage activation. But the functional polarization of activated macrophages and its underlying molecular mechanism during pathogenesis SLE remains unknown. As an important local cellular interaction responsible for cell fate determination, Notch signaling is reported exert crucial functions in development differentiation various immunocytes, whereas role not...
A new selective fluorescent chemosensor for the detection of GSH, Cys/Hcy from dual emission channels.
Abstract Macrophage differentiation and polarization is influenced by, act on, many processes associated with autoimmunity. However, the molecular mechanisms underlying macrophage in systemic lupus erythematosus (SLE) remain largely debated. We previously demonstrated that M2b conferred by activated lymphocyte-derived (ALD)-DNA immunization could initiate propagate murine nephritis. Serum amyloid P component (SAP), a conserved acute-phase protein mice, has been reported to bind DNA modulate...
Objective: To investigate the clinical significance of IL-10 + tumor-associated macrophages (TAMs) in gastric cancer. Background: Due to plasticity and diversity TAMs, it is necessary phenotypically functionally classify subsets TAMs better understand critical role cancer progression. expressing interleukin-10 (IL-10) have been found facilitate immune evasion many malignancies, but remains obscure. Methods: Four hundred sixty-eight tumor tissue microarray specimens, 52 fresh samples patients...
A highly selective and sensitive turn-on red fluorescent 1-amino BODIPY-based probe (where BODIPY denotes indole-based boron-dipyrromethene) with high off-to-on contrast ratio has been developed. The displayed response to thiophenols over aliphatic thiols. Probe 1 is promising for the quantitative detection of thiophenol a linear from 6 × 10(-6) M 10(-4) M, limit (PhSH) reaches 4 measured in acetonitrile/PBS buffer. could be improved 37 nM (detection ppb) water when 1% Tween 20 was used...
Abstract The CXC chemokine receptor 4 (CXCR4) exerts a variety of functions at different steps hepatocellular carcinoma (HCC) progression. molecular mechanisms and therapeutic value CXCR4 in the development HCC remain undefined. Here we show that aberrant overexpression is associated with poor prognosis aggressive characteristics HCC. Suppression activity via knockdown, AMD3100 or neutralizing antibody administration inhibits hepatoma cell tumorigenesis vitro vivo . displays opposite...
T-cell immunoglobulin and ITIM domain (TIGIT) is identified as a novel checkpoint receptor that can facilitate immune escape via mediating exhaustion in tumors. However, the clinical significance contexture correlation of intratumoral TIGIT+ CD8+ T-cells remain to be further explored muscle-invasive bladder cancer (MIBC).259 patients with MIBC from two centers (Zhongshan Hospital, n=141; Shanghai Cancer Center, n=118) were analyzed evaluate prognostic value association through...
Abstract Tumor-associated macrophages (TAM) play an indispensable role in the modulation of cancer immune microenvironment. Despite fact that TAMs may exert both antitumor and protumor activities, molecular mechanisms involved remain poorly understood. Here, we characterized a subpopulation expressing dendritic cell–specific C-type lectin (DC-SIGN) investigated its relevance to prognosis microenvironment muscle-invasive bladder (MIBC). DC-SIGN+ were abundant significant proportion human MIBC...
Abstract RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with unique binding sites in 3′-untranslated region. There is mounting information that suggests RBP dysregulation plays a significant role carcinogenesis. However, function FMR1 autosomal homolog 1(FXR1) malignancies just beginning to be unveiled. Due diversity their domains and functional adaptability, FXR1 can regulate diverse transcript...
Ecological restoration is the guarantee of regional ecological security. Accurate identification areas crucial for planning programs. However, question how to recognize range at pixel scale in order improve efficiency still requires further discussion. In this study, a framework that integrates security and feasibility through multi-criteria decision analysis was developed identify priority (ERPAs) Qinghai-Tibet Plateau (QTP). The results showed with low accounted 58.33 % QTP, primarily...
The E3 ubiquitin ligase murine double minute 2 (MDM2) binds the p53 transcriptional activation domain and acts as a potent inhibitor of TP53 pathway, one three most crucial oncogenic pathways in urothelial carcinoma (UC). However, clinical significance impact on tumor immune contexture MDM2 amplification UC remain unclear. This study analyzed 240 patients with matched annotations from two local cohorts (ZSHS cohort FUSCC cohort). We assessed correlation between status outcomes, therapeutic...
Purpose Fake news refers to intentionally fabricated or misleading information designed deceive the public and manipulate opinions for personal, political financial gain. Most existing detection methods primarily focus on capturing language features from content. However, these neglect varying importance of different entities. Additionally, tend overlook auxiliary role external knowledge, resulting in an incomplete understanding entity. To address issues, this paper aims propose a Dual-layer...
This paper presents the design and implementation of a wireless-controllable power outlet system for home automation networks. The proposed module integrates ZigBee radio into its architecture. It acts as an actuator node in networks remote control operations. A prototype following architecture has been implemented. testbed simple network validating basic functions also created. Results demonstration experiment show that enables easy flexible various appliances with little infrastructure....
Abstract Background and aims In gastric cancer, the response rate of programmed cell death protein‐1 (PD‐1) inhibitor is far from satisfactory, indicating additional nonredundant pathways might hamper antitumour immunity. V‐domain immunoglobulin suppressor T‐cell activation (VISTA) has been reported in several malignancies as a novel immune‐checkpoint. Nevertheless, role VISTA cancer still remains obscure. Our purpose to explore clinical significance potential mechanism affecting patients’...
DNA-dependent activator of interferon-regulatory factors (DAI) functions as a cytoplasmic DNA sensor that activates the innate immune system. We previously found activated lymphocyte-derived self-apoptotic (ALD-DNA) immunization led to pathological macrophage activation and M2b polarization, which could initiate propagate murine lupus nephritis. However, specific sensor(s) well underlying molecular mechanisms involved in ALD-DNA-induced polarization systemic erythematosus (SLE) disease...