A5101682424- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Immune cells in cancer
- Gastrointestinal Tumor Research and Treatment
- Galectins and Cancer Biology
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Helicobacter pylori-related gastroenterology studies
- Mast cells and histamine
- Chromatin Remodeling and Cancer
- Peptidase Inhibition and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Inflammatory Biomarkers in Disease Prognosis
- Nerve injury and regeneration
- IgG4-Related and Inflammatory Diseases
- Toxin Mechanisms and Immunotoxins
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2016-2025
State Key Laboratory of Medical Neurobiology
2011-2012
Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, regulatory effect on immune surveillance in remains obscure. Design Flow cytometry analyses were performed to examine major source and phenotypes cells fresh tumour tissues from 76 patients with cancer. Real-time PCR was analyse mRNA level tissues. For immunohistochemical analyses, a total 420 undergoing curative resection enrolled. In...
This study was aimed to investigate the prognostic value of tumor-infiltrating neutrophils (TINs) and generate a predictive model refine postoperative risk stratification system for patients with gastric cancer.TIN presents in various malignant tumors, but its clinical significance cancer remains obscure.The enrolled 3 independent sets from 2 institutional medical centers China. TIN estimated by immunohistochemical staining CD66b, relationship clinicopathological features outcomes were...
Objective: To investigate the clinical significance of IL-10 + tumor-associated macrophages (TAMs) in gastric cancer. Background: Due to plasticity and diversity TAMs, it is necessary phenotypically functionally classify subsets TAMs better understand critical role cancer progression. expressing interleukin-10 (IL-10) have been found facilitate immune evasion many malignancies, but remains obscure. Methods: Four hundred sixty-eight tumor tissue microarray specimens, 52 fresh samples patients...
Abstract Studies that examined an association between CD8 + T and prognosis in gastric cancer are inconsistent, a distinct population of CXCR5 associated with better overall survival has been reported among various malignancies. Here, we show the abundance intratumoral cells is patients cancer. Patients TNM II III higher cell infiltration more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable Epstein–Barr virus positive tumors enriched cells. Gastric infiltrating...
Intratumoural CD103+CD8+ T cells have been linked to prolonged survival in several malignancies. However, the clinical significance of gastric cancer remains unexplored.Gastric tissues from Zhongshan Hospital and data Gene Expression Omnibus were obtained analysed. Immunohistochemistry flow cytometry performed detect number phenotypical characteristics cells. The effect programmed cell death protein-1 (PD-1) blockade on was evaluated with use an vitro study based fresh tumour...
Abstract Background Although PD-1 has been reported to be a marker of T-cell exhaustion in several malignancies, the biological role + CD8 T cells gastric cancer (GC) remains unclear. Herein, we aimed investigate tumour microenvironment and its clinical significance GC. Designs This study included 441 microarray specimens 60 Flow cytometry GC patients from Zhongshan Hospital, 250 Asian Cancer Research Group . Results Here, demonstrated that functioned as an independent adverse prognosticator...
Abstract In gastric cancer (GC), the therapeutic response of immune checkpoint blockade (ICB) remains suboptimal. Targeting myeloid cell checkpoints might be feasible as adjuvant to current ICB regimens. We sought evaluate crucial role C5aR1 + TAMs in regulating antitumor immunity and efficacy combinatorial treatment with antiprogrammed death protein‐1 (PD‐1) blockade. Here, we found that was predominantly expressed on macrophages high level infiltration could predict poor prognosis inferior...
This study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric cancer (GC), explore mechanism Dectin-1 regulating tumour-associated macrophage (TAM)-mediated immune evasion GC.The association Dectin-1+ cells with outcomes was inspected by immunohistochemistry on tumour microarrays. Flow cytometry RNA sequencing were applied detect characteristics T cells, phenotypic transcriptional features TAMs. The effect blockade...
Interneurons in the olfactory bulb (OB) represent a heterogeneous population, which are first produced at embryonic stages and persisting into adulthood. Using BrdU birthdating method combined with immunostaining for several different neuronal markers, we provide integrated temporal patterns of distinct mouse OB interneuron production from day 14 to postnatal 365. We show that although majority subtypes continue be generated throughout life, most similar "bell-like" pattern peak around...
Purpose: Tumor-infiltrating γδT cells (γδTILs) have different prognostic value and functions among various cancers. The aim of the present study was to evaluate effect γδTILs in gastric cancer.Patients methods: A discovery set (n = 190) a validation 273) were involved this study. Patients with TNM II III disease used predict response 5-fluorouracil (5-FU)-based adjuvant chemotherapy (ACT) both sets. defined as intense (γδT cells≥ 5/HPF) versus nonintense cells<5/HPF). Kaplan-Meier curve...
As an adverse survival prognosticator, chemokine (C-X-C motif) ligand 13 (CXCL13) has been studied in several types of malignancies. The secretion and physiological roles CXCL13 follicular helper T cells (TFH) have well described, while the clinical significance CD8+ tumor-infiltrating lymphocytes (TILs)-associated remains unknown. This study aims to investigate CXCL13+CD8+ chemotherapeutic responsiveness prediction gastric cancer. In this study, 440 patients enrolled from Zhongshan Hospital...
AT-rich interaction domain 1A (ARID1A) encodes a vital component of switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with genomic instability, we conducted this study to determine whether ARID1A mutation status had an impact on therapeutic responsiveness in gastric cancer (GC), especially combinatory chemo-immunotherapy.We retrospectively enrolled total 1162 patients from five independent cohorts. ZSHS Cohort and TCGA were designed inform chemotherapeutic...
Background With the essential role of interleukin-1 signaling in cancer-related inflammation, IL-1R1, main receptor for both IL-1α and IL-1β, demonstrated therapeutic potential several types cancer, which has been put into clinical trials. However, expression profile critical IL-1R1 gastric cancer (GC) remain obscure. This study aimed to investigate prognostic significance its predictive value chemotherapy immunotherapy GC. Methods The enrolled three cohorts, consisting 409 tumor microarray...
This study aimed to reveal the effect of TP53 status on clinical outcomes and underlying mechanism in gastric cancer (GC) patients.
Objective Immunotherapy has not yielded satisfactory therapeutic responses in gastric cancer (GC). However, targeting myeloid checkpoints holds promise for expanding the potential of immunotherapy. This study aims to evaluate critical role Siglec-10 + tumor-associated macrophages (TAMs) regulating antitumor immunity and explore checkpoint as an interventional target. Design TAMs were assessed based on immunohistochemistry tumor microarrays RNA-sequencing data. Flow cytometry, RNA sequencing,...
Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3B (APOBEC3B) plays an important role in tumor mutagenesis. However, its clinical significance gastric cancer (GC) remains largely unknown. We enrolled a total of 482 GC patients from Zhongshan Hospital, Fudan University for immunohistochemistry (IHC) staining to evaluate the prognostic and predictive values APOBEC3B. Genomic phenotypic datasets Cancer Genome Atlas (TCGA) Asian Research Group (ACRG) cohort were downloaded external...
// Chao Lin 1, * , Hao Liu Heng Zhang Hongyong He 1 Li Zhenbin Shen Jin Qin Xinyu Jiejie Xu 2 Yihong Sun Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China Biochemistry and Molecular Biology, School Basic Medical Sciences, These authors contributed equally to this work Correspondence to: Sun, email: sun.yihong@zs-hospital.sh.cn Xu, jjxufdu@fudan.edu.cn Keywords: gastric cancer, IL-13R-α2, overall survival, prognostic biomarker, nomogram Received: March 17,...
<h3>Importance</h3> Loss of O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT) protein expression has been reported in several malignant tumors and predicts dismal survival outcomes. In gastric cancer, existing studies on this topic are limited the association between MGMT fluorouracil-based adjuvant chemotherapy remains obscure. <h3>Objective</h3> To investigate postoperative prognostic significance patients with resectable cancer its responsiveness to chemotherapy. <h3>Design,...