A5037504776- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Chemokine receptors and signaling
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Higher Education Learning Practices
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Venous Thromboembolism Diagnosis and Management
- Biochemical Analysis and Sensing Techniques
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Educational Assessment and Improvement
Fudan University
2016-2025
Xuzhou Medical College
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Peking Union Medical College Hospital
2023-2025
Zhongshan Hospital
2017-2025
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Sun Yat-sen University
2017-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2023
Huashan Hospital
2020
Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, regulatory effect on immune surveillance in remains obscure. Design Flow cytometry analyses were performed to examine major source and phenotypes cells fresh tumour tissues from 76 patients with cancer. Real-time PCR was analyse mRNA level tissues. For immunohistochemical analyses, a total 420 undergoing curative resection enrolled. In...
Objective: To investigate the clinical significance of IL-10 + tumor-associated macrophages (TAMs) in gastric cancer. Background: Due to plasticity and diversity TAMs, it is necessary phenotypically functionally classify subsets TAMs better understand critical role cancer progression. expressing interleukin-10 (IL-10) have been found facilitate immune evasion many malignancies, but remains obscure. Methods: Four hundred sixty-eight tumor tissue microarray specimens, 52 fresh samples patients...
Abstract Studies that examined an association between CD8 + T and prognosis in gastric cancer are inconsistent, a distinct population of CXCR5 associated with better overall survival has been reported among various malignancies. Here, we show the abundance intratumoral cells is patients cancer. Patients TNM II III higher cell infiltration more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable Epstein–Barr virus positive tumors enriched cells. Gastric infiltrating...
Intratumoural CD103+CD8+ T cells have been linked to prolonged survival in several malignancies. However, the clinical significance of gastric cancer remains unexplored.Gastric tissues from Zhongshan Hospital and data Gene Expression Omnibus were obtained analysed. Immunohistochemistry flow cytometry performed detect number phenotypical characteristics cells. The effect programmed cell death protein-1 (PD-1) blockade on was evaluated with use an vitro study based fresh tumour...
Abstract Background Although PD-1 has been reported to be a marker of T-cell exhaustion in several malignancies, the biological role + CD8 T cells gastric cancer (GC) remains unclear. Herein, we aimed investigate tumour microenvironment and its clinical significance GC. Designs This study included 441 microarray specimens 60 Flow cytometry GC patients from Zhongshan Hospital, 250 Asian Cancer Research Group . Results Here, demonstrated that functioned as an independent adverse prognosticator...
Abstract In gastric cancer (GC), the therapeutic response of immune checkpoint blockade (ICB) remains suboptimal. Targeting myeloid cell checkpoints might be feasible as adjuvant to current ICB regimens. We sought evaluate crucial role C5aR1 + TAMs in regulating antitumor immunity and efficacy combinatorial treatment with antiprogrammed death protein‐1 (PD‐1) blockade. Here, we found that was predominantly expressed on macrophages high level infiltration could predict poor prognosis inferior...
This study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric cancer (GC), explore mechanism Dectin-1 regulating tumour-associated macrophage (TAM)-mediated immune evasion GC.The association Dectin-1+ cells with outcomes was inspected by immunohistochemistry on tumour microarrays. Flow cytometry RNA sequencing were applied detect characteristics T cells, phenotypic transcriptional features TAMs. The effect blockade...
Purpose: Tumor-infiltrating γδT cells (γδTILs) have different prognostic value and functions among various cancers. The aim of the present study was to evaluate effect γδTILs in gastric cancer.Patients methods: A discovery set (n = 190) a validation 273) were involved this study. Patients with TNM II III disease used predict response 5-fluorouracil (5-FU)-based adjuvant chemotherapy (ACT) both sets. defined as intense (γδT cells≥ 5/HPF) versus nonintense cells<5/HPF). Kaplan-Meier curve...
As an adverse survival prognosticator, chemokine (C-X-C motif) ligand 13 (CXCL13) has been studied in several types of malignancies. The secretion and physiological roles CXCL13 follicular helper T cells (TFH) have well described, while the clinical significance CD8+ tumor-infiltrating lymphocytes (TILs)-associated remains unknown. This study aims to investigate CXCL13+CD8+ chemotherapeutic responsiveness prediction gastric cancer. In this study, 440 patients enrolled from Zhongshan Hospital...
AT-rich interaction domain 1A (ARID1A) encodes a vital component of switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with genomic instability, we conducted this study to determine whether ARID1A mutation status had an impact on therapeutic responsiveness in gastric cancer (GC), especially combinatory chemo-immunotherapy.We retrospectively enrolled total 1162 patients from five independent cohorts. ZSHS Cohort and TCGA were designed inform chemotherapeutic...
Background With the essential role of interleukin-1 signaling in cancer-related inflammation, IL-1R1, main receptor for both IL-1α and IL-1β, demonstrated therapeutic potential several types cancer, which has been put into clinical trials. However, expression profile critical IL-1R1 gastric cancer (GC) remain obscure. This study aimed to investigate prognostic significance its predictive value chemotherapy immunotherapy GC. Methods The enrolled three cohorts, consisting 409 tumor microarray...
This study aimed to reveal the effect of TP53 status on clinical outcomes and underlying mechanism in gastric cancer (GC) patients.
Objective Immunotherapy has not yielded satisfactory therapeutic responses in gastric cancer (GC). However, targeting myeloid checkpoints holds promise for expanding the potential of immunotherapy. This study aims to evaluate critical role Siglec-10 + tumor-associated macrophages (TAMs) regulating antitumor immunity and explore checkpoint as an interventional target. Design TAMs were assessed based on immunohistochemistry tumor microarrays RNA-sequencing data. Flow cytometry, RNA sequencing,...
Exosomes are nano-sized extracellular vesicles containing different biomolecules such as proteins and microRNAs (miRNAs) that mediate intercellular communication. Recently, numerous studies have reported the important functions of exosomal miRNAs in disease development potential clinical application diagnostic biomarkers. Up to now, most commonly used methods extract exosomes ultracentrifugation (UC) precipitation-based commercial kit (e.g., ExoQuick). Generally, both UC ExoQuick method...
Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3B (APOBEC3B) plays an important role in tumor mutagenesis. However, its clinical significance gastric cancer (GC) remains largely unknown. We enrolled a total of 482 GC patients from Zhongshan Hospital, Fudan University for immunohistochemistry (IHC) staining to evaluate the prognostic and predictive values APOBEC3B. Genomic phenotypic datasets Cancer Genome Atlas (TCGA) Asian Research Group (ACRG) cohort were downloaded external...
Norepinephrine (NE) released from locus coeruleus (LC) noradrenergic (NAergic) neurons plays a pivotal role in the regulation of olfactory behaviors. However, precise circuits and receptor mechanisms underlying this function are not well understood. Here, DBH-Cre mice model, we show that LC NAergic project directly to both anterior piriform cortex (aPC) bulb (OB). By using pharmacological optogenetic manipulations vitro vivo, found NE reduces excitability aPC pyramidal via α2 receptors it...
<h3>Importance</h3> Loss of O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT) protein expression has been reported in several malignant tumors and predicts dismal survival outcomes. In gastric cancer, existing studies on this topic are limited the association between MGMT fluorouracil-based adjuvant chemotherapy remains obscure. <h3>Objective</h3> To investigate postoperative prognostic significance patients with resectable cancer its responsiveness to chemotherapy. <h3>Design,...