A5062047914- Sirtuins and Resveratrol in Medicine
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Sperm and Testicular Function
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Ion Transport and Channel Regulation
- Adenosine and Purinergic Signaling
- Calcium signaling and nucleotide metabolism
- Organ Transplantation Techniques and Outcomes
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Kruppel-like factors research
- Hepatitis B Virus Studies
- Reproductive Biology and Fertility
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
Shanghai Jiao Tong University
2016-2025
Renji Hospital
2012-2025
Zhejiang University
2006-2024
First Affiliated Hospital Zhejiang University
2005-2024
State Key Laboratory of Oncogene and Related Genes
2015-2023
Shanghai Cancer Institute
2023
Shanghai Chest Hospital
2023
Medizinische Hochschule Hannover
2012-2020
Defence Electronics Research Laboratory
2020
Bridge University
2019
The timely restructuring of the blood–testis barrier (BTB) that facilitates migration preleptotene and leptotene spermatocytes from basal to adluminal compartment in seminiferous epithelium adult rat testes, which occurs at late stage VII through early VIII epithelial cycle, is a crucial cellular event spermatogenesis. However, regulation BTB dynamics biochemical level remains elusive. In this study, tumor necrosis factor α (TNFα), secretory product Sertoli germ cells was shown affect...
The treatment for metastatic castration-resistant prostate cancer patients remains a great challenge in the clinic and continuously demands discoveries of new targets therapies. Here, we assess function therapeutic value SIRT6 cancer.
Extracellular vesicles (EVs) released from cells have shown robust efficacy in drug delivery compared with traditional synthetic carriers. Hampered by the high production cost and complex purification process, clinical application of EVs as carriers is still limited. Nanoparticles isolated plants exosome-like morphology similar effects could be a new option for delivery. The celery nanovesicles (CELNs) showed higher cellular uptake efficiency to other three common plant-derived nanovesicles,...
Abstract Aim Downregulated in adenoma ( DRA , Slc26a3) is a member of the solute carrier family 26 SLC 26), anion transporters, which mutated familial chloride‐losing diarrhoea (CLD). Besides Cl − ‐rich diarrhoea, CLD patients also have higher‐than‐average incidence intestinal inflammation. In search for potential explanations this clinical finding, we investigated colonic electrolyte transport, mucus layer and susceptibility against dextran sodium sulphate DSS )‐induced colitis Slc26a3 −/−...
Neuroinflammation mediated by activation of microglia and interruption the blood-brain barrier (BBB) is an important factor that contributes to neuron death infarct area diffusion in ischemia reperfusion injury. Finding novel molecules regulate neuroinflammation significant clinical value. We have previously shown adjudin, a small molecule compound known possess antispermatogenic function, attenuates suppression NF-κB pathway. In this study we continued explore whether adjudin could be...
// Yizhou Quan 1 , Naitao Wang Qianqian Chen Jin Xu Wei Cheng 2 Meijuan Di 3 Weiliang Xia and Wei-Qiang Gao 1,4 State Key Laboratory of Oncogenes Related Genes, Renji-MedX Clinical Stem Cell Research Center, Ren Ji Hospital, School Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China Department Urology, First People’s Hospital of Xiaoshan, Hangzhou, Zhejiang, Pathology, 4 Collaborative Innovation Center Systems Biomedicine, Correspondence to: Xia, email: Gao,...
Abstract Immune Check-Point Inhibitors (ICIs) have shown remarkable promise in treating tumors, including non-small cell lung cancer (NSCLC). Nevertheless, the treatment response rate is low. Studies found that high expression of exosomal PD-L1 one reasons for low response. Therefore, this study focused on relationship between and clinical to immunotherapy NSCLC patients evaluate whether it could be used as a biomarker predict efficacy ICIs. In study, information blood samples 149 receiving...
With its well-documented toxicity, the use of doxorubicin (Dox) for cancer treatment requires trade-offs between safety and effectiveness. This limited Dox also hinders functionality as an immunogenic cell death inducer, thus impeding usefulness immunotherapeutic applications. Here, we develop a biomimetic pseudonucleus nanoparticle (BPN-KP) by enclosing GC-rich DNA within erythrocyte membrane modified with peptide to selectively target healthy tissue. By localizing organs susceptible...
Apical ectoplasmic specialization (ES) is a unique testis-specific cell-cell actin-based adherens junction type restricted to the Sertoli-round/elongating/elongate spermatid interface in seminiferous epithelium. An endogenous testosterone (T) suppression model was used study regulation of apical ES dynamics testis. By providing sustained releases T and estradiol using subdermal implants rats, this treatment reduced testicular level. This turn led sloughing spermatids (step 8 beyond) from...
The mixing of gastric and pancreatic juice subjects the jejunum to unique ionic conditions with high luminal CO2 tension HCO3 − concentration. We investigated role small intestinal apical anion exchangers PAT-1 (Slc26a6) DRA (Slc26a3) in basal CO2/HCO3 −-stimulated jejunal fluid absorption. Single pass perfusion segments was performed anaesthetised wild type (WT) as well mice deficient DRA, PAT-1, Na+/H+ exchanger 3 (NHE3) or NHE2, carbonic anhydrase II (CAII). Unbuffered saline (pH 7.4) WT...
In Brief Recent studies reported the translocator protein (TSPO) to play critical roles in several kinds of neurological diseases including inflammatory and neuropathic pain. However, precise mechanism remains unclear. This study was undertaken explore distribution possible spinal TSPO against chronic pain (CNP) a rat model L5 nerve ligation (SNL). Our results showed that upregulated time-related manner dorsal horn after SNL. Spinal predominately expressed astrocytes. A single intrathecal...
Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development complex. Amplification fibroblast growth factor receptor 1 (FGFR1) one the most frequent targets lung squamous cell carcinoma (SQCC). Whether 2 (FGF2)/FGFR1 contributes regulation remains elusive. Autophagic activity was evaluated by immunoblotting for microtubule-associated protein light chain 3 (LC3), formation GFP-LC3 puncta, and monodansylcadaverine (MDC) staining....
Abstract MicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, metastasis. However, the regulatory mechanism between miRNAs FGFR1 lung cancer remains unclear extremely critical. miR-214-3p was sharply decreased showed a significantly negative correlation with patients ( n = 30). Luciferase reporter assay confirmed that could downregulate by directly targeting 3′-untranslated region (UTR)....
With the revolutionary progress of immune checkpoint inhibitors (ICIs) in non–small cell lung cancer, identifying patients with cancer who would benefit from ICIs has become critical and urgent. Here, we report protein tyrosine phosphatase receptor type T (PTPRT) loss as a precise convenient predictive marker independent PD-L1 expression for anti–PD-1/PD-L1 axis therapy. Anti–PD-1/PD-L1 treatment markedly increased progression-free survival PTPRT-deficient tumors. tumors displayed cumulative...
Objectives To investigate if perinatal Omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplementation can improve sevoflurane-induced neurotoxicity and cognitive impairment in neonatal rats. Methods Female Sprague-Dawley rats (n = 3 each group) were treated with or without an n-3 PUFAs (fish oil) enriched diet from the second day of pregnancy to 14 days after parturition. The offspring (P7) six hours sevoflurane administration (one group sevoflurane/prenatal supplement as control)....