A5101651749- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Hippo pathway signaling and YAP/TAZ
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Echinoderm biology and ecology
- Colorectal and Anal Carcinomas
- Total Knee Arthroplasty Outcomes
- Lymphoma Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Orthopaedic implants and arthroplasty
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
Shanghai Jiao Tong University
2016-2025
Beijing Anzhen Hospital
2025
Capital Medical University
2024-2025
Ocean University of China
2024-2025
Shanghai Chest Hospital
2016-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Beijing Tian Tan Hospital
2025
Academy of Military Medical Sciences
2024
Southern Medical University
2021-2024
Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by complicated inflammation-related pathological processes, such as excessive reactive oxygen species (ROS) produced the infiltrated inflammatory immune cells released to extracellular microenvironment, leading widespread apoptosis of neuron cells, glial oligodendroctyes. In this study, a thioketal-containing ROS-scavenging hydrogel was prepared for encapsulation bone marrow derived mesenchymal stem...
The histone acetyltransferase MOF is a member of the MYST family. In mammals, plays critical roles by acetylating H4 at K16 and non-histone substrates such as p53. Here we have investigated role in human lung cancer possible new hMOF.Samples non-small cell (NSCLC) were used to correlate with clinicopathological parameters NF-E2-related factor 2 (Nrf2) downstream genes. 293T-cells study interactions between Nrf2, acetylation Nrf2 MOF. Mouse embryonic fibroblast A549 cells utilized assess...
Malignant pleural effusion (MPE), the presence of malignant cells in fluid, is often first sign many cancers and occurs patients with metastatic malignancies. Accurate detection tumor fluid crucial because MPE denotes an advanced stage disease directs a switch clinical managements. Cytology, as traditional diagnostic tool, has limited sensitivity especially when are not abundant, may be confounded by reactive mesothelial fluid. We describe highly sensitive approach for rapid metabolically...
Unlike other epithelial cancer types, circulating tumor cells (CTCs) are less frequently detected in the peripheral blood of non-small cell lung (NSCLC) patients using marker-based detection approaches despite aggressive nature NSCLC. Here, we demonstrate hexokinase-2 (HK2) as a metabolic function-associated marker for CTCs. In 59 NSCLC bearing cytokeratin-positive (CKpos) primary tumors, HK2 enables resolving cytokeratin-negative (HK2high/CKneg) CTCs prevalent population about half samples...
Thymic epithelial tumors (TETs) are a relatively rare type of thoracic tumor, accounting for less than 1% all tumors. The incidence TETs is about 3.93/10000 in China, slightly higher that European and American countries. For resectable TETs, complete surgical resection recommended. Radiotherapy or chemotherapy may be used as postoperative adjuvant treatment. Treatment advanced, unresectable consist mainly radiotherapy chemotherapy, but there lack standard first- second-line treatment...
The objective of this study is to explore clinical risk factors for venous thromboembolism (VTE) in postoperative lung cancer patients order provide a basis the prevention and treatment VTE.A total 1,001 were retrospectively analyzed. Each patient was confirmed with surgical pathology diagnosis had complete follow-up record. VTE identified combination spiral computed tomography (CT), pulmonary angiography, color Doppler ultrasound. We used life table method create an occurrence frequency...
EZH2 is a key component of the polycomb PRC2 complex and functions as histone H3 Lys27 (H3K27) trimethyltransferase. Here we show that down-regulated in human non-small cell lung cancer low expression predicts poor survival. Further demonstrate inhibits proliferation colony formation vitro growth vivo. We found binds to promoter Nrf2, where it increases H3K27me3 represses Nrf2 expression. Finally, seems be essential for hyper cells absence EZH2.
Abstract MicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, metastasis. However, the regulatory mechanism between miRNAs FGFR1 lung cancer remains unclear extremely critical. miR-214-3p was sharply decreased showed a significantly negative correlation with patients ( n = 30). Luciferase reporter assay confirmed that could downregulate by directly targeting 3′-untranslated region (UTR)....
Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known promote non-small cell lung cancer (NSCLC).In this work, we determined role SIRT6 in EMT NSCLC cells identified key EMT-related genes involved oncogenic activity SIRT6.We report that depletion inhibits transforming growth factor-β1 (TGF-β1)-induced A549 H1299 cells, which rescued by ectopic expression SIRT6. Knockdown leads a...
Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore function tumor progression LSCC.Main methods: mRNA was measured using qRT-PCR. Protein assessed by Western blot. Cell migration and invasion were transwell assay.Key findings: co-overexpressed FGFR1 lung cancer patients. Overexpression promoted LSCC cell proliferation metastasis. processes EMT through AKT/MAPK signaling targeting FGFR1-amplification...
Abstract Background Non-small cell lung cancer (NSCLC) is one of the predominant malignancies globally. Percutaneous thermal ablation (PTA) has gained widespread use among NSCLC patients, with potential to elicit immune responses but limited therapeutic efficacies for advanced-stage disease. T-helper type 9 (Th9) cells are a subset CD4 + effector T robust and persistent anti-tumor effects. This study proposes develop PTA-Th9 integrated therapy as strategy treatment. Methods The were measured...
Non-small cell lung cancer (NSCLC) patients with EGFR mutations exhibit an unfavorable response to immune checkpoint inhibitor (ICI) monotherapy, and their tumor microenvironment (TME) is usually immunosuppressed. TGF-β plays important role in immunosuppression; however, the effects of on TME efficacy anti-PD-1 immunotherapy against EGFR-mutated tumors remain unclear.
Abstract The mechanisms of anxiety disorders, the most common mental illness, remain incompletely characterized. ventral hippocampus (vHPC) is critical for expression anxiety. However, current studies primarily focus on vHPC neurons, leaving role astrocytes in largely unexplored. Here, genetically encoded Ca 2+ indicator GCaMP6m and vivo fiber photometry calcium imaging are used to label monitor their activity, respectively, genetic chemogenetic approaches inhibit activate astrocytes,...
// Ziming Li 1, * , Jia Huang Hong Yuan 1 Zhiwei Chen Qingquan Luo Shun Lu Shanghai Lung Tumor Clinical Medical Center, Chest Hospital, Jiao Tong University, 200030, People's Republic of China These authors have contributed equally to this work Correspondence to: Lu, e-mail: shun_lu14@163.com Luo, wen_li14@163.com Keywords: lung cancer, cell cycle, acetylation Received: December 15, 2015 Accepted: February 14, 2016 Published: March 01, ABSTRACT Skp2 is a component the E3 ubiquitin ligase...
// Wenxiang Ji 1, 2 , Yongfeng Yu 1 Ziming Li Guan Wang 3 Fan Weiliang Xia Shun Lu Shanghai Lung Cancer Center, Chest Hospital, Jiao Tong University, 200030, China State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Ren School Biomedical Engineering, Genomics WuXiAppTec Co., Ltd., 200131, Correspondence to: Xia, e-mail: wlxia@sjtu.edu.cn Lu, shun_lu@hotmail.com Keywords: FGFR1, GLI2, lung squamous cell cancer, stem cell-like phenotype Received: August...
Abstract Lung cancer occurrence and associated mortality ranks top in all countries. Despite the rapid development of targeted immune therapies, many patients experience relapse within a few years. It is urgent to uncover mechanisms that drive lung progression identify novel molecular targets. Our group has previously identified FGF19 as prognostic marker potential driver gene squamous cell carcinomas (LSQ) Chinese smoking patients. However, underlying mechanism how promotes LSQ remains...
Tumor-infiltrating B cells and tertiary lymphoid structures have been identified to predict the responses immune checkpoint inhibitors (ICIs) in cancer immunotherapy. Considering feasibility of sample collection, whether peripheral cell signatures are associated with ICI therapy remains unclear. Herein, we defined advanced non-small lung (NSCLC) patients receiving anti-PD-1 monotherapy investigated their associations clinical efficacy. It was found that percentages before treatment...
Abstract The fusion genes NRG1 and NRG2, members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, retains its EGF-like active domain, binds to ERBB ligand triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. incidence gene varies across cancer types, with lung being most prevalent at 0.19 0.27%. CD74 SLC3A2 are frequently observed partners. RNA-based next-generation sequencing is primary method for...
Immune checkpoint inhibitors have revolutionized non-small cell lung cancer (NSCLC) treatment but may pose greater technical challenges for surgery. This study aims to assess the feasibility and oncological effectiveness of video-assisted thoracoscopic surgery (VATS) resectable stage III NSCLC after neoadjuvant immunochemotherapy.