A5060939298- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Renal cell carcinoma treatment
- Single-cell and spatial transcriptomics
- Radiomics and Machine Learning in Medical Imaging
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Medicinal Plants and Neuroprotection
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Lung Cancer Diagnosis and Treatment
- Aerodynamics and Acoustics in Jet Flows
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blockchain Technology Applications and Security
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Hubei University of Medicine
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Chongqing Cancer Hospital
2023
Chongqing University
2023
Institute for Systems Biology
2020-2023
Western University of Health Sciences
2023
University of Southern California
2023
Purple Mountain Laboratories
2022
Malignant pleural effusion (MPE), the presence of malignant cells in fluid, is often first sign many cancers and occurs patients with metastatic malignancies. Accurate detection tumor fluid crucial because MPE denotes an advanced stage disease directs a switch clinical managements. Cytology, as traditional diagnostic tool, has limited sensitivity especially when are not abundant, may be confounded by reactive mesothelial fluid. We describe highly sensitive approach for rapid metabolically...
Unlike other epithelial cancer types, circulating tumor cells (CTCs) are less frequently detected in the peripheral blood of non-small cell lung (NSCLC) patients using marker-based detection approaches despite aggressive nature NSCLC. Here, we demonstrate hexokinase-2 (HK2) as a metabolic function-associated marker for CTCs. In 59 NSCLC bearing cytokeratin-positive (CKpos) primary tumors, HK2 enables resolving cytokeratin-negative (HK2high/CKneg) CTCs prevalent population about half samples...
Previously, our group and others have demonstrated a causative relationship between severe hypertriglyceridaemia atherogenesis in mice. Furthermore, clinical investigations shown high levels of plasma Apolipoprotein C-III (ApoCIII) associated with even cardiovascular disease. However, it remains unclear whether ApoCIII affects restenosis vivo, such an effect is mediated by alone, or combination hypertriglyceridaemia. We sought to investigate clarify how smooth muscle cells (SMCs) respond...
The high glucose uptake and activation of oncogenic signaling pathways in cancer cells has long made these features, together with the mutational spectrum, prime diagnostic targets circulating tumor (CTCs). Further, an ability to characterize properties at a single cell resolution is widely believed be essential, as known extensive heterogeneity CTCs can obscure important correlations data obtained from population-based methods. However, date, it not been possible quantitatively measure...
Abstract Accurate prediction of chemo- or targeted therapy responses for patients with similar driver oncogenes through a simple and least-invasive assay represents an unmet need in the clinical diagnosis non-small cell lung cancer. Using single-cell on-chip metabolic cytometry fluorescent probes, we show phenotyping on rare disseminated tumor cells pleural effusions across panel 32 adenocarcinoma patients. Our results reveal extensive heterogeneity that differentially engage glycolysis...
Obesity is associated with many severe chronic diseases and deciphering its development molecular mechanisms necessary for promoting treatment. Previous studies have revealed that mitochondrial content down-regulated in obesity, diabetes, nonalcoholic fatty liver disease (NAFLD) proposed NAFLD diabetes are diseases. However, the exact underlying these processes remain unclear. In this study, we discovered resistin activities of mitochondria, enhanced hepatic steatosis, induced insulin...
We describe a one-step microfludics-based immunomagnetic isolation method to isolate CTCs directly from the whole blood of lung adenocarcinoma patients. This avoids harsh sample preparation and enrichment steps, therefore preserves viability during in vitro isolation. Importantly, isolated, magnetic bead-bearing are concentrated small volume culture medium with high CTC density. High cell culturing density promote ex vivo expansion limited numbers CTCs. Expanded characterized at genetic,...
Bladder cancer (BC) is a common malignancy worldwide that accounts for 3% of global diagnoses. Chemotherapy resistance limits the therapeutic effect chemotherapeutic agents in patients with BC. Prolyl 4-hydroxylase, beta polypeptide (P4HB) an endoplasmic reticulum (ER) chaperone upregulated bladder tissues (The Cancer Genome Atlas, TCGA datasets). Knockdown or suppression P4HB exerts anticancer activity and sensitizes cells to chemotherapy various types cancer.We aimed investigate whether...
The Practical Byzantine Fault Tolerant (PBFT) consensus algorithm has many advantages, which makes PBFT utilized widely. Nonetheless, is not suitable for large-scale node scenarios due to its high communication complexity and it also an apparent disadvantage of inadequate fault tolerance. typically derived algorithms focus on reducing at the cost diminished system security or In this paper, Dual-Primary-Node Tolerance (DPNPBFT) proposed achieve best balance above three performances. First,...
Introduction The efficacy of Telitacicept treatment in reducing proteinuria patients with IgA nephropathy (IgAN) was indicated a phase II clinical trial small sample size. In this study, we conducted large multicenter retrospective study to explore the and safety IgAN. Methods This recruited IgAN from 19 sites China who were treated had been followed up at least once or side effect reported, since April 1, 2021 2023. primary outcomes changing eGFR over time. Results A cohort 97 recruited,...
Chemokine receptors have a crucial role in regulating tumor mediating immunity and are also implicated the prognosis of some cancers. Here, association between CXC chemokine (CXCR2-5) osteosarcoma was studied.Differences CXCR2, CXCR3, CXCR4, CXCR5 expression overall survival (OS) event-free (EFS) were compared using Kaplan-Meier analyses. The associations CXCR3 with clinical features analyzed. signaling pathways modulated by investigated. correlations immune infiltrates investigated.The not...
Abstract Allo CAR T cells represent an “off-the-shelf” treatment option that addresses the unmet need for immediately available, potentially curative therapies. CRISPR Therapeutics’ first generation allo cell products, CTX110® (CD19-directed) and CTX130TM (CD70-directed), have shown encouraging efficacy in ongoing clinical trials (NCT04035434, NCT04502446, NCT04438083), including complete durable responses B- T-cell lymphoma renal carcinoma (RCC). However, exhaustion, occurring even prior to...
Purpose: To evaluate the dynamics of early serum tumour markers (STMs) and neutrophil-to-lymphocyte ratio (NLR) to predict clinical efficacy prognosis advanced non-small-cell lung cancer (NSCLC) patients who received programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors. Patients Methods: We retrospectively reviewed with NSCLC treated PD-1/PD-L1 inhibitors between September 2017 August 2020. NLR STMs were routinely measured immunotherapy initiation first radiological...
Our previous study indicated that 8 patients from a family with history of congenital heart disease had simple atrial septal defect (ASD) and carried the same mutation at codon 310 in GATA4 gene. In present study, to identify functional defects caused by this an vivo model, transgene DNA constructs were microinjected into mice generate transgenic mouse model. The genotyped using PCR sequencing. Protein expression was measured western blot analysis. qPCR used determine copy number transgenes....
Abstract Voltage-gated e ther à go-go (EAG) K + channels are expressed in various types of cancer cells and also the central nervous system. Aberrant overactivation human EAG1 (hEAG1) is associated with neuronal disorders such as Zimmermann-Laband Temple-Baraitser syndromes. Although hEAG1 recognized potential therapeutic targets, regulation their functional properties only poorly understood. Here, we show that membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP 2 ) a potent inhibitory...
To explore the effect and mechanism of peppermint essential oil on learning memory ability APP/PS1 transgenic mice.Morris water maze test shuttle box were used to changes in mice after sniffing oil. The cellular status neurons hippocampal CA1 region right hemisphere, Aβ deposition, oxidative stress level, serum metabonomics detected its mechanism.Sniffing can improve mice. Compared with model group, state group returned normal, deposition decreased. MDA brain tissue decreased significantly,...
This study established an experimental mouse model of trauma-hemorrhagic shock (THS). THS-induced mice (C57BL/6J, n=33) were subjected to femoral fracture, ischemia for 90 min, and resuscitation 15 min. The sham-operated underwent the same anesthetic surgical procedures, but neither trauma-hemorrhage nor fluid performed. Mean arterial pressure (MAP) microvascular tissue perfusion over small intestine, liver, left kidney longitudinally measured in all mice. Blood was collected analysis at...
Our objective was to explore the mechanism of essential oil that extracted from Cinnamomum camphora chvar. Borneol (Borneol oil) for improving learning and memory impairment in mice. Brain tissue plasma samples a normal group, model group reference were detected using gas chromatography time-of-flight mass spectrometry (GC-TOFMS) order find differential metabolites analyze metabolic pathways. Results showed there 11 different --including glycine azelaic acid --in samples, 26...