A5101702668- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Protease and Inhibitor Mechanisms
- Congenital heart defects research
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Renal and Vascular Pathologies
- Erythropoietin and Anemia Treatment
- Trace Elements in Health
- Blood Pressure and Hypertension Studies
- Extracellular vesicles in disease
- Genetic and Kidney Cyst Diseases
- Blood disorders and treatments
- Renal and related cancers
- Infectious Aortic and Vascular Conditions
- Peripheral Artery Disease Management
- Potassium and Related Disorders
- Iron Metabolism and Disorders
- Ferroptosis and cancer prognosis
- Connective tissue disorders research
- Vasculitis and related conditions
- Bone health and treatments
- Central Venous Catheters and Hemodialysis
Harbin Medical University
2006-2024
Second Affiliated Hospital of Harbin Medical University
2006-2024
Fudan University Shanghai Cancer Center
2013
Shanghai Medical College of Fudan University
2013
Nippon Medical School
2010-2012
First Affiliated Hospital of Harbin Medical University
2006
Renal fibrosis is a common finding in progressive renal diseases. Matrix metalloproteinases (MMPs) are involved epithelial-to-mesenchymal transition (EMT). We investigated the role of MMP-2 and effect inhibition MMPs on development fibrosis. was induced wild-type (MMP-2⁺/⁺) mice by unilateral ureteral obstruction (UUO). histopathology, EMT-associated molecules, activity MMP-9 were examined during interstitial UUO-renal also deficient (MMP-2⁻/⁻) MMP-2⁺/⁺ treated with minocycline (inhibitor...
Introduction The efficacy of Telitacicept treatment in reducing proteinuria patients with IgA nephropathy (IgAN) was indicated a phase II clinical trial small sample size. In this study, we conducted large multicenter retrospective study to explore the and safety IgAN. Methods This recruited IgAN from 19 sites China who were treated had been followed up at least once or side effect reported, since April 1, 2021 2023. primary outcomes changing eGFR over time. Results A cohort 97 recruited,...
<b><i>Background/Aims:</i></b> Matrix metalloproteinases (MMPs) are zinc endopeptidases that degrade extracellular matrix and involved in the pathogenesis of ischemic damage acute kidney injury (AKI). In present study, we analyzed role MMP-2 repair process AKI. <b><i>Methods:</i></b> AKI was induced wild-type (MMP-2<sup>+/+</sup>) MMP-2-deficient (MMP-2<sup>-/-</sup>) mice by 90-min renal artery clamping followed...
Abstract Background The prevalence of idiopathic membranous nephropathy (IMN) is increasing worldwide and the gut microbiota recognized to play a role in its pathology. aim this study was understand involvement gut–kidney axis IMN by analyzing composition biopsy-proven patients compared with healthy controls (HC). Methods Fecal samples from 30 diagnosed renal biopsy co-residents (control group) were collected for analysis Nephrology Department Second Affiliated Hospital Harbin Medical...
ABSTRACT Background To explore the cut-off values of haemoglobin (Hb) on adverse clinical outcomes in incident peritoneal dialysis (PD) patients based a national-level database. Methods The observational cohort study was from Peritoneal Dialysis Telemedicine-assisted Platform (PDTAP) dataset. primary were all-cause mortality, major cardiovascular events (MACE) and modified MACE (MACE+). secondary occurrences hospitalization, first-episode peritonitis permanent transfer to haemodialysis (HD)....
Abstract Background IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, and its diagnosis depends mainly on renal biopsy. However, there no specific treatment for IgAN. Moreover, causes underlying molecular events require further exploration. Methods The expression profiles GSE64306 GSE93798 were downloaded from Gene Expression Omnibus (GEO) database used to identify differential miRNAs genes, respectively. StarBase TransmiR databases employed predict...
<b><i>Introduction:</i></b> Telemedicine (TM) has shown to provide potential benefits on clinical outcomes in patients with chronic kidney disease but limited evidences published the peritoneal dialysis (PD) population. This study aimed explore long-term effects of TM mortality and technique failure. <b><i>Methods:</i></b> The Peritoneal Dialysis Telemedicine-assisted Platform Cohort Study (PDTAP Study) was conducted prospectively 27 hospitals...
Abstract Background and Aims Primary membranous nephropathy (PMN) is the most common cause of nephrotic syndrome (NS) in adults currently considered an autoimmune-related disease. B cell depleting treatments, commonly used rituximab, are usually effective treating (MN). However, about 35% patients treated with rituximab fail to respond, relapses after RTX-induced remission frequent. Among new anti-B therapeutics, obinutuzumab has shown significant efficacy refractory MN, including those that...
Renal fibrosis is the most important feature of progression chronic kidney disease (CKD), and epithelial-mesenchymal transition (EMT) plays an role in renal fibrosis. Dedicator cytokinesis protein 2 (Dock2) involved immune system development a variety fibrotic diseases. However, its specific remains unclear. Therefore, this study, we investigated mechanism Dock2 We constructed vivo mouse model unilateral ureteral obstruction (UUO) vitro recombinant human transforming growth factor-β1...
To explore the predictive value of proportion glomerulosclerosis (GS) incidences on progression membranous nephropathy with non-nephrotic proteinuria (NNP).This study was a single-center, retrospective, cohort study. Patients biopsy-proven idiopathic were divided into three groups based glomerular sclerosis, and their demographic, clinical, pathological data compared. The proportions primary secondary endpoints recorded, relationship between GS outcomes (progression to nephrotic syndrome,...
Introduction: Renal osteodystrophy (ROD) is a type of bone metabolic disorder in patients with chronic kidney disease (CKD). Inflammation associated loss ROD. However, its precise mechanism has not yet been elucidated. The present study was conducted to investigate whether exosomes (Exos) marrow (BM) are involved the pathogenesis high-turnover
The aim of the present study was to investigate antioxidant response mechanism epigallocatechin‑3‑gallate (EGCG) in H2O2‑induced mouse renal tubular epithelial cells (MRTECs). cultured MRTECs were divided into normal, H2O2 (control) and EGCG treatment groups. MTT assay used assess cell viability, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), immunocytochemical western blot analyses performed detect expression nuclear factor erythroid 2‑related 2 (Nrf2) γ‑glutamyl...
Abstract Background and Aims Clinically, left renal vein (LRV) entrapment is almost equivalent to the nutcracker phenomenon (NCP). However, there still much uncertainty debate about prevalence of NCP its diagnostic criteria. As a particular type LRV entrapment, compression by right artery (RRA) was primarily reported as case reports. The study designed investigate RRA-sourced in two selected patient cohorts. Method cross-sectional consecutively 38 hospitalized kidney patients diagnosed with...
Although more and cardiovascular risk factors have been verified in peritoneal dialysis (PD) populations different countries regions, it is still difficult for clinicians to accurately individually predict death the near future. We aimed develop validate machine learning-based models near-term all-cause death. Machine learning were developed among 7539 PD patients, which randomly divided into a training set an internal test by five random shuffles of 5-fold cross-validation, 3 months. chose...
Adipose mesenchymal stem cells (ADSCs) exert beneficial effects on kidney disease through a paracrine mechanism. However, the specific molecular mechanisms by which ADSCs treat renal fibrosis are not yet fully understood. Therefore, it is crucial to clarify therapeutic of ADSC-derived extracellular vesicles (ADSC-EVs) progression and their underlying mechanisms. We investigated ADSC-EVs both in vivo vitro. Key genes signaling pathways were identified with RNA sequencing analysis HK-2 cells....
Iron metabolism markers, such as transferrin saturation (TSAT) and ferritin, are crucial in anemia management patients with CKD those undergoing dialysis, yet optimal levels remain unelucidated. We conducted a prospective multicenter cohort study using data from the nationwide Peritoneal Dialysis Telemedicine-based Management Platform (PDTAP) to analyze TSAT, hemoglobin (Hb) levels, their associations mortality peritoneal dialysis (PD) population. Our included 4429 PD patients, analyzing...
Objective This study aimed to determine the effect of parathyroid hormone-related protein (PTHrP) on proliferation cardiac fibroblasts (CFs) in primary cultures neonatal Wistar rats. Methods Different PTHrP concentrations were added CFs rats and cells grouped according added. A verapamil (VPL) group a calcitriol (CAL) also established. Changes cell cyclic adenosine monophosphate calcium ion levels identified recorded. Results We found that as concentration increased, 3-(4,...