A5015790145- Respiratory Support and Mechanisms
- Pharmacological Effects of Natural Compounds
- Acupuncture Treatment Research Studies
- Dialysis and Renal Disease Management
- Traditional Chinese Medicine Studies
- Glioma Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Cancer Treatment and Pharmacology
- Hydrogen's biological and therapeutic effects
- Nanoparticle-Based Drug Delivery
- Tryptophan and brain disorders
- Erythropoietin and Anemia Treatment
- Natural product bioactivities and synthesis
- Nausea and vomiting management
- Diabetes Treatment and Management
- Analytical Methods in Pharmaceuticals
- Immune Response and Inflammation
- High Altitude and Hypoxia
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Antiplatelet Therapy and Cardiovascular Diseases
- Flavonoids in Medical Research
- Mine drainage and remediation techniques
- Plant-based Medicinal Research
- Heme Oxygenase-1 and Carbon Monoxide
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2025
Zhejiang Chinese Medical University
2022-2025
Tianjin University
2018-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2013-2024
Second Affiliated Hospital of Fujian Medical University
2022-2024
Fujian Medical University
2022-2024
Capital Medical University
2020-2024
Sun Yat-sen University
2024
Hospital of Hebei Province
2020-2024
Beijing Shijitan Hospital
2020-2024
African American breast cancer patients have lower frequency of hormone receptor-positive (HR+)/human epidermal growth factor receptor 2 (HER2)-negative disease and higher subtype-specific mortality. Racial differences in molecular subtype within clinically defined subgroups are not well understood.Using data biospecimens from the population-based Carolina Breast Cancer Study (CBCS) Phase 3 (2008-2013), we classified 980 invasive cancers using RNA expression-based PAM50 recurrence (ROR)...
nab-paclitaxel demonstrates improved clinical efficacy compared with conventional Cremophor EL (CrEL)-paclitaxel in multiple tumor types. This study explored the distinctions drug distribution between and CrEL-paclitaxel underlying mechanisms. Uptake transcytosis of paclitaxel were analyzed by vascular permeability assay across human endothelial cell monolayers. The tissue penetration within tumors was evaluated local injections into xenografts quantitative image analysis. profile...
Resveratrol, a plant-derived polyphenolic compound and phytoestrogen, was shown to possess multiple protective effects including anti-inflammatory response anti-oxidative stress. Hypoxic pulmonary hypertension (HPH) is progressive disease characterized by sustained vascular resistance marked remodeling. The exact mechanisms of HPH are still unclear, but inflammatory oxidative stress demonstrated participate in the progression HPH. present study designed investigate resveratrol on...
Annually, tens of millions first-ever strokes occur in the world; however, currently there is lack effective and widely applicable pharmacological treatments for stroke patients. Herbal medicines, characterized as multi-constituent, multi-target multi-effect, have been acknowledged with conspicuous effects treating stroke, attract extensive interest researchers although mechanism action yet unclear. In this work, we introduce an innovative systems-pharmacology method that combines...
Abstract Oxycodone is a commonly used analgesic with large body of pharmacokinetic data from various immediate‐release or controlled‐release formulations, under different administration routes, and in diverse populations. Longer terminal half‐lives extravascular as compared to IV have been attributed flip‐flop pharmacokinetics the rate constant absorption slower than elimination. However, PK parameters studies showed faster Sustained release formulations guided by concept produced mixed...
Abstract Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia. Design Multicentre, open label, randomised trial. Setting 15 hospitals China between December 2017 2020. Participants 412 significant hyperglycaemia (HbA 1c ≥8.5%). Interventions All...
Objectives To compare physical information, such as age, sex, height, weight, body mass index (BMI) and pulmonary function test (PFT) results, between cough variant asthma (CVA) chronic (CC) establish a diagnostic model of CVA. Design A case–control study patients with suspected CVA enrolled at The First Affiliated Hospital Zhejiang Chinese Medical University. Setting One leader unit the National Key Specialised Pulmonary Disease Cooperation Group in China. Participants Enrolled 545 who...
Malignant gliomas are the most common and aggressive primary brain tumor, for which differentiation therapy has emerged as a promising candidate strategy. In this study, we used in vitro vivo assays to examine effects of wogonin, major active constituent Scutellaria baicalensis, on glioma C6 U251 cells. We found that wogonin can suppress cell proliferation induce G0/G1 arrest under concentration-dependent manner. Wogonin also triggered significant reduction G1 cell-cycle regulatory proteins...
Osteoporosis (OP) is a common skeletal disease, characterized by decreased bone formation and increased resorption. As novel Chinese medicine formula, Zhuanggu Busui formula (ZGBSF) has been proved to be an effective prescription for treating OP in clinic, however, the pharmacological mechanisms underlying beneficial effects remain obscure. In this study, we explored of ZGBSF against via network pharmacology analysis coupled with vivo experimental validation. The results showed that total 86...
Abstract A highly feasible and reliable ultra‐high performance liquid chromatography tandem mass spectrometry method was presented for therapeutic drug monitoring of five anti‐schizophrenic drugs (amisulpride, olanzapine, aripiprazole, paliperidone ziprasidone) simultaneously. To meet the requirements practical clinical usage (easy handling, high throughput cost effectiveness), pretreatment process simplified (only including protein precipitation mobile phase dilution steps) UPLC separation...
Breast cancer is the most common carcinoma in women. Comprehensive therapy on breast including surgical operation, chemotherapy, radiotherapy, endocrinotherapy, etc. could help, but still has serious side effect and resistance against anticancer drugs. Complementary alternative medicine (CAM) may avoid these problems, which traditional Chinese (TCM) been highlighted. In this section, to analyze mechanism through TCM act cancer, we have built a virtual model consisting of construction...
Purpose The role of exercise to prevent or reverse aging-induced cognitive decline has been widely reported. This neuroprotection is associated with changes in the synaptic structure plasticity. However, mechanisms exercise-induced plasticity aging brain are still unclear. Thus, aim present study investigate aging-related alterations Rho-GTPase and modulatory influences training. Methods Young old rats were used this study. Old subjected different schedules aerobic (12 m/min, 60 min/d, 3d/w...
Objectives: Complement activation product C5a plays a critical role in systemic inflammatory response syndrome induced by viruses, bacteria, and toxic agents including paraquat poisoning. This study is to explore the efficiency of anti-C5a–based intervention on responses Design: Study cynomolgus macaque model plasma from paraquat-poisoning patients. Setting: Laboratory investigation. Subjects: Cynomolgus ( n = 12) samples patients 16). Interventions: The neutralizing antihuman antibody...
Abstract Resveratrol is a natural phytoalexin synthesized by plants, including grapes. It displays wide range of neuroprotective benefits associated with anti-aging. Recent studies have shown that resveratrol regulates dopaminergic transmission and behavioral effects drugs abuse. The goal the present study to investigate whether how alters basal inhibitory synaptic cocaine-induced plasticity in dopamine neurons ventral tegmental area (VTA). We report elevated cAMP levels itself further...
ABSTRACT Background To explore the cut-off values of haemoglobin (Hb) on adverse clinical outcomes in incident peritoneal dialysis (PD) patients based a national-level database. Methods The observational cohort study was from Peritoneal Dialysis Telemedicine-assisted Platform (PDTAP) dataset. primary were all-cause mortality, major cardiovascular events (MACE) and modified MACE (MACE+). secondary occurrences hospitalization, first-episode peritonitis permanent transfer to haemodialysis (HD)....
Previous studies have shown that different paclitaxel formulations produce distinct anticancer efficacy and safety profiles in animals humans. This study aimed to investigate the pharmacokinetics tissue distribution of various nanoformulations paclitaxel, which may translate into potential differences efficacy. Four nanoparticle (nab-paclitaxel, mouse albumin nab-paclitaxel [m-nab-paclitaxel], micellar polymeric paclitaxel) as well solvent-based were intravenously administered mice....
The plasma enhanced oil based drug, named activated radix arnebiae (PARAO) is produced in the (RAO) by a single-step, room temperature, energy-efficient and environment-friendly dry plasma-enabled process. streamer-surface discharge generates abundant energetic species, atomic oxygen at plasma-oil interface. dissociation of C = double bond species oxidization main mechanism to produce reactive H2O2 carboxylic acid PARAO, while decreasing shikonin caused very limited. highly PARAO can not...