A5101806817- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Research Studies
- Acupuncture Treatment Research Studies
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
- Cell Adhesion Molecules Research
- Nitric Oxide and Endothelin Effects
- Cytokine Signaling Pathways and Interactions
- Antimicrobial Peptides and Activities
- Intestinal and Peritoneal Adhesions
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hernia repair and management
- Cancer Immunotherapy and Biomarkers
- Vagus Nerve Stimulation Research
Annoroad Gene Technology (China)
2025
Xi'an High Tech University
2025
Air Force Engineering University
2020-2025
Nanjing Drum Tower Hospital
2016-2024
Chongqing University
2017-2024
Wuhan University
2024
Nanjing Medical University
2019-2024
Nanjing University of Chinese Medicine
2020-2024
Jiangsu Province Hospital
2021
Houston Methodist
2011-2018
Abstract Tumor-associated macrophages (TAM) have multifaceted roles in tumor development but they been associated particularly closely with angiogenesis. However, although the accumulation of TAM (M2 phenotype) promotes angiogenesis, mechanism through which monocytes differentiate to generate is unclear. Here, we report that mTOR pathway a critical element regulation monocyte differentiation TAM. In human peripheral stimulated by lipopolysaccharide, was inhibited rapamycin or activated RNA...
Primary pulmonary lymphoepithelial carcinoma (pLEC) is a subtype of non-small cell lung cancer (NSCLC) characterized by Epstein-Barr virus (EBV) infection. However, the molecular pathogenesis pLEC remains poorly understood. In this study, we explored using whole-exome sequencing (WES) and RNA-whole-transcriptome (RNA-seq) technologies. Datasets normal tissue, other types NSCLC, EBV-positive nasopharyngeal (EBV+-NPC) were obtained from public databases. Furthermore, described gene signatures,...
Peripheral serotonin is involved in tumorigenesis and induces a pro-proliferative effect hepatocellular carcinoma (HCC) cells; however, the intracellular mechanisms by which exerts mitogenic remain unclear. In this research, we examined whether FOXO3a, transcription factor at interface of crucial cellular processes, plays role downstream HCC cells.The cell viability expression FOXO3a was assessed three lines (Huh7, HepG2 Hep3B) during serum deprivation presence or absence serotonin. Serum...
Extensive reprogramming of cellular energy metabolism is a hallmark cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show that 14-3-3σ regulates cancer and protects cells from tumorigenic transformation. opposes tumour-promoting programmes by enhancing c-Myc poly-ubiquitination subsequent degradation. demonstrates suppressive impact on glycolysis, glutaminolysis, mitochondrial biogenesis other major...
Abstract Purpose: Advanced pancreatic cancer has remained challenging to treat effectively. This study aimed investigate the clinical effects and safety of immunotherapy with dendritic cells cytokine-induced killer (DC-CIK) administered chemotherapy (CT) S-1 in this malignancy. Experimental Design: Consecutive patients (n = 47) advanced were treated either DC-CIK + S-1, alone, or best supportive care. Results: plus produced significantly longer median OS PFS (212 136 days) compared (128 85...
Refractory wound healing is one of the most common complications diabetes. Excessive production reactive oxygen species (ROS) can cause chronic inflammation and thus impair cutaneous healing. Scavenging these ROS in dressing may offer effective treatment for wounds. Here, a nanocomposite hydrogel based on alginate positively charged Eudragit nanoparticles containing edaravone, an efficient free radical scavenger, was developed maximal sequestration. enhanced edaravone solubility stability...
Abstract Anoikis is a type of programmed cell death induced by detachment from the extracellular matrix. In cancer cells, anoikis resistance essential for survival in blood circulation and distant metastasis. However, mechanisms behind gastric remain largely unknown. Herein, we demonstrate that NADPH oxidase 4 (NOX4) expression reactive oxygen species (ROS) generation are upregulated suspension cultures compared with adherent cultures. Silencing NOX4 decreases ROS downregulates EGFR,...
We have assessed the combination of DC-CIK with S-1 plus cisplatin chemotherapy in advanced gastric cancer (AGC) and role mutational analysis circulating tumor DNA (ctDNA) T-cell receptor (TCR) repertoire predicting clinical outcomes.Consecutive patients (n = 63) AGC were allocated to treatment alone, cisplatin, combined or cisplatin. The primary endpoints progression-free survival (PFS) overall (OS) at 1 year; secondary disease control rate ctDNA TCR repertoire.The infusions well tolerated...
Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. However, little known about the molecular landscape and efficacy of therapy in HER2-mutated metastatic cancer. We analysed HER2 mutation features 1184 invasive In addition, a single-arm, prospective, phase-II study (NCT03412383) pyrotinib was conducted patient...
Abstract Gastric cancer is one of the most common malignancies worldwide and vasculogenic mimicry (VM) considered to be leading cause for failure anti-angiogenesis therapy in advanced gastric patients. In present study, we investigate role tenascin-c (TNC) formation VM found that TNC was upregulated tissue than corresponding adjacent tissues correlated with poor prognosis cancer. Furthermore, knockdown significantly inhibited proliferation cells vitro vivo, a reduction cell migration...
Abstract BACKGROUND: Mutations in the tumor protein 53 ( TP53 ) suppressor gene are common head and neck squamous cell carcinoma (HNSCC) correlate with radioresistance. Currently, there no clinically available therapeutic approaches targeting p53 HNSCC. In this report, authors propose a strategy that uses mutational status to individualize antimetabolic strategies for potentiation of radiation toxicity HNSCC cells. METHODS: Glycolytic flux mitochondrial respiration were evaluated wild‐type...
Cationic antimicrobial peptides (CAMPs) are potent therapeutics for drug-resistant bacterial infections. However, the clinical application of CAMPs is hampered by its poor proteolytic stability and hemolytic activity toward eukaryotic cells. Great efforts have been made to design generate derivatives with improved pharmacological properties. Here, we report a novel stapling protocol, which tethers two ε-amino groups lysine residue N-alkylation reaction on hydrophilic face amphiphilic...
G protein coupled estrogen receptor (GPER1) is a membrane receptor, belonging to the seven-transmembrane protein-coupled receptors family, and has important biological functions in cancer. However, functional role of GPER1 gastric cancer (GC) remain incompletely understood. In present study, we employed gene set enrichment analysis discovered that expression was concomitant with EMT process positively correlated activation PI3K/AKT pathway GC. Knockdown siRNA suppressed proliferation,...
// Wenhu Liu 1, 2, 3 , Jinxia Chang 4 Mingwei 2 Jiangbei Yuan 1 Jinqiang Zhang Jun Qin 5, 6 Xuefeng Xia and Yi Wang School of Pharmaceutical Sciences Innovative Drug Research Center, Chongqing University, 401331, China State Key Laboratory Proteomics, National Center for Protein Sciences, Beijing Proteome 102206, Pharmacy, North Sichuan Medical College, Nanchong 637007, Basic 5 Verna Marrs McLean Department Biochemistry Molecular Biology, Baylor College Medicine, Houston, Texas 77030, USA...
The extracellular matrix (ECM) plays a central role in the formation of tumor microenvironment. deposition ECM is associated with poor prognosis variety tumors. Aberrant could undermine effect chemotherapy and immunotherapy. However, there no systematic analysis on relationship between or effect. In present study, we applied gene set variation (GSVA) algorithm to score 2199 canonical pathways 2125 cases probe sequencing data identified core matrisome as driving factor gastric cancer...
Atezolizumab plus bevacizumab has shown promising efficacy in advanced mucosal melanoma the multi-centre phase II study. This report updates 3-year survival outcomes and multi-omics analysis to identify potential response biomarkers.
Pyroptosis has been recently identified as a hallmark of cancer biology; however, the potential pyroptosis-related genes (PRGs) prognostic markers not fully elucidated in hepatocellular carcinoma (HCC). The aim this study was to develop PRG-associated risk signature for prediction prognosis patients with HCC. We 35 PRGs from published literature, and pyroptosis subtypes were through bioinformatics methods. score model established by applying least absolute shrinkage selection operator...
The bypass dual-throat nozzle is based on the nozzle, which a fluidic thrust vector suitable for integration into rocket motors in symmetrical manner. As effects of gas–solid two-phase flows are essential solid (SRMs), this study employs RNG k–ε turbulence model and particle trajectory to numerically simulate three-dimensional flow field inside fixed-geometry axisymmetric investigate its characteristics vectoring performance. Numerical results reveal that smaller-diameter particles exhibit...
Abstract Background Cetuximab [an epidermal growth factor receptor ( EGFR ) inhibitor], which was shown to be effective in rectal and non‐small cell lung cancers NSCLC s), only modestly clinical trials of hepatocellular carcinoma HCC ). STAT 3, is thought a determinant sensitivity antitumour drugs, may involved. Aims To evaluate the efficacy combination therapy using cetuximab NSC 74859 (a novel 3 inhibitor) overexpressing hepatoma cells. Methods Hepatoma lines were treated with cetuximab,...
Acute graft-versus-host disease is a serious and life-threatening complication of liver transplantation (LT) that occurs in 1% to 2% allograft recipients. It associated with high mortality rate, effective therapies are lacking. In our established rat model, relative decrease regulatory T cells (Tregs) was previously shown be acute after (LT-aGVHD). Mesenchymal stem (MSCs) have been used treat allogeneic hematopoietic cell transplantation, they induce Tregs, which immunomodulatory effects....