A5101874898- Antimicrobial Peptides and Activities
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Vibration Control and Rheological Fluids
- Structural Engineering and Vibration Analysis
- Biochemical and Structural Characterization
- Hydraulic and Pneumatic Systems
- Wound Healing and Treatments
- Psoriasis: Treatment and Pathogenesis
- Seismic Performance and Analysis
- Underwater Vehicles and Communication Systems
- Contact Mechanics and Variational Inequalities
- 3D Printing in Biomedical Research
- Metal-Organic Frameworks: Synthesis and Applications
- Nanocluster Synthesis and Applications
- Chemical Synthesis and Analysis
- Natural Compounds in Disease Treatment
- Acupuncture Treatment Research Studies
- Supramolecular Self-Assembly in Materials
- Dendrimers and Hyperbranched Polymers
- Geotechnical Engineering and Analysis
- Control and Stability of Dynamical Systems
- Ginkgo biloba and Cashew Applications
Hubei University of Technology
2022-2025
Shanghai Institute of Ceramics
2025
Chinese Academy of Sciences
2023-2025
ShanghaiTech University
2025
Heilongjiang University of Chinese Medicine
2025
Chongqing University
2020-2024
Tianjin University
2024
Beijing Institute of Nanoenergy and Nanosystems
2023
Guangxi University
2023
Harvard University
2020
Abstract Background The prevalence and clinical characteristics of psoriatic arthritis (PsA) in patients with psoriasis vary widely different countries studies on Chinese population are rarely reported. Objective aim this study was to evaluate the PsA a psoriasis. Methods A large cross‐sectional observational conducted our outpatient dermatology department consecutive were evaluated for according Classification Psoriatic (CASPAR) criteria. Demographic medical parameters recorded. Results...
Metal nanowires are promising for their applications including electrical connectors, transparent conductive electrodes and additives, but the use of metal as photothermal agents to convert light heat has yet be reported. Here we synthesized dispersible polyethylene glycol-coated (PEGylated) copper (CuNWs) showed first time that PEGylated CuNWs were able near-infrared (NIR, 808 nm) into at a efficiency 12.5%. The exhibited good reusability enabled rapid temperature rise >50 °C in 6 min by...
Developing clean and renewable energy sources is an important strategy to reduce carbon emission achieve neutrality. As one of the most promising sources, large-scale, efficient utilization ocean blue remains a challenging problem be solved. In this work, hyperelastic network wheel-structured triboelectric nanogenerators (WS-TENGs) demonstrated efficiently harvest low-frequency small-amplitude wave energy. Different from traditional designs smooth shell, external blades on TENG allow tighter...
Rationale: Cisplatin (CDDP) is a broad-spectrum anticancer drug but chemoresistance to CDDP impedes its wide use for cancer therapy. Autophagy an event occurring in the cytoplasm and cytoplasmic LC3 puncta formation hallmark of autophagy. Graphene oxide (GO) nanomaterial that provokes autophagy CT26 colon cells confers antitumor effects. Here we aimed evaluate whether combined GO with (GO/CDDP) overcomes different uncover underlying mechanism. Methods: We treated GO/CDDP evaluated...
Cationic antimicrobial peptides (CAMPs) are potent therapeutics for drug-resistant bacterial infections. However, the clinical application of CAMPs is hampered by its poor proteolytic stability and hemolytic activity toward eukaryotic cells. Great efforts have been made to design generate derivatives with improved pharmacological properties. Here, we report a novel stapling protocol, which tethers two ε-amino groups lysine residue N-alkylation reaction on hydrophilic face amphiphilic...
Cationic antimicrobial peptides (CAMPs) are promising for treatment of multidrug-resistant (MDR) bacteria-caused infections. However, clinical application CAMPs has been hampered mostly due to their poor proteolytic stability and hemolytic toxicity. Recently, lysine-stapled developed by us had proved increase peptide in vitro without induction hemolysis. Herein, the applicability lysine stapling strategy was further explored using five natural or artificial as model peptides. Lysine...
Perillae Fructus (PF) is a common traditional Chinese medicine (TCM) for the treatment of asthma. It has not been effectively characterized by rosmarinic acid (RosA), which currently designed as sole quality indicator in Pharmacopoeia.
The emergence of multidrug-resistant bacteria has led to an urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) exhibit broad-spectrum and highly effective antibacterial activity are less prone resistance, making them potential candidates the next generation drugs. However, screening AMPs from a vast library through wet lab experiments is slow laborious process. By leveraging large datasets labeled peptides, researchers utilize deep learning algorithms train models that...
Herein, a flexible and free-standing (substrate-free) PVDF/Ag2Se (Polyvinylidene fluoride) composite film was successfully fabricated through combination of drop-casting heat treatment. It observed that when the drop-casted heated above melting point PVDF, small separated Ag2Se crystalline grains in grow interconnect to form three-dimensional (3D) conductive network increase carrier mobility, while molten PVDF effectively fills voids enhance flexibility mechanical strength. As result, both...
Traditional Chinese Medicine (TCM) culture is a treasure of the nation. It provides modern medicine with invaluable wisdom through its clinical principles holistic view, syndrome differentiation and treatment, Yin-Yang Five Elements, "preventing disease before onset", as well philosophical tenets human-centeredness moderate harmony. TCM holds significant advantages in prevention, rehabilitation. First, compared to aggressive methods Western drug resistance pharmaceuticals, exhibits minimal...
Antimicrobial peptides (AMPs) have attracted great attention as next generation antibiotics for the treatment of multidrug-resistant (MDR) bacterial infections. Poor proteolytic stability has however undermined clinical applications AMPs. A novel peptide cyclization approach is described to enhance in vivo antibacterial activity Bicyclic antimicrobial were synthesized by cross-linking ε-amino groups three lysine residues with a 1,3,5-trimethylene benzene spacer. In proof principal study,...
As antibiotic resistance increasingly undermines traditional infection management strategies, there is a critical demand for innovative wound care solutions that address these emerging challenges. This study introduces novel antibacterial dressing based on Cross-Linked Pullulan (Pul) and Polyhexamethylene Biguanide (PHMB) enhanced control. The dressing’s adsorption rate reached 200% of its original weight within 30 min, exceeded 300% after 5 h, exhibited significant non-Newtonian fluid...
Characterization of HIV viral rebound after the discontinuation antiretroviral therapy is central to cure research. We propose a parametric nonlinear mixed effects model for trajectory, which often has rapid rise peak value followed by decrease load set point. choose flexible functional form that captures shapes trajectories and can also provide biological insights regarding process. Each parameter incorporate random effect allow variation in parameters across individuals. Key features such...
Antioxidant peptides derived from Radix Angelicae sinensis can inhibit ferroptosis by directly inhibiting Keap1–Nrf2 PPI.
Nitric oxide (NO)-releasing platforms have been demonstrated as promising approaches for the reversal of multidrug resistance (MDR) in cancer cells due to suppression P-glycoprotein (P-gp). However, non-specific systemic release NO and difficulty estimating precise amount target sites hindered their translational applications. Traditional bioimaging techniques which are responsive molecules cannot distinguish between exogenous endogenous NO. Herein we introduce S-nitrosothiol-functionalized...
Abstract Introduction Ginkgo Folium tablet (GFT) is a patented traditional Chinese medicine prepared from biloba leaves extract (GBE). However, the current quality indicators for GFT or GBE as designated by Pharmacopoeia are insufficient in preventing counterfeit events. Objective This study aimed to putatively identify compounds and further develop marker (Q‐marker) system GFT. Methods A novel strategy utilizing database‐aided ultrahigh‐performance liquid chromatography‐quadrupole‐orbitrap...
4',5,7-OHs are common substituents of natural flavonoids, a type effective phenolic antioxidant. However, the antioxidant processes between 4',5,7-trihydroxyflavonoids with different structural types have not been compared systematically, and products challenging to determine. This study four 4',5,7-trihydroxyflavonoids, including apigenin, genistein, kaempferol, naringenin. In quantum chemical analyses, showed thermodynamic properties, C4'-OH (or C3-OH kaempferol) possessed strongest...