A5081262245- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Adrenal and Paraganglionic Tumors
- 14-3-3 protein interactions
- Medical Imaging Techniques and Applications
- Advanced NMR Techniques and Applications
- ATP Synthase and ATPases Research
- Glioma Diagnosis and Treatment
- Enzyme Structure and Function
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Macrophage Migration Inhibitory Factor
- Protein Degradation and Inhibitors
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Microbial Natural Products and Biosynthesis
- FOXO transcription factor regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- DNA Repair Mechanisms
- Cancer Risks and Factors
- TGF-β signaling in diseases
- Genetic and Kidney Cyst Diseases
Defense Health Agency
2025
David Grant USAF Medical Center
2022-2025
The University of Texas MD Anderson Cancer Center
2011-2023
Vietnam National University Ho Chi Minh City
2014
University of Houston
2012
Chi Mei Medical Center
2010
China Medical University
2010
First Hospital of China Medical University
2010
China Medical University
2010
Abstract Obesity is associated with an increased risk of developing breast cancer and also worse clinical prognosis. The mechanistic link between obesity progression remains unclear, there has been no development specific treatments to improve the outcome obese patients. Here we show that obesity-associated NLRC4 inflammasome activation/ interleukin (IL)-1 signalling promotes progression. tumour microenvironment in context induces increase tumour-infiltrating myeloid cells activated turn...
Aurora B is a mitotic checkpoint kinase that plays pivotal role in the cell cycle, ensuring correct chromosome segregation and normal progression through mitosis. overexpressed many types of human cancers, which has made it an attractive target for cancer therapies. Tumor suppressor p53 genome guardian important negative regulator cycle. Whether are coordinately regulated during cycle not known. We report directly interacts with at different subcellular localizations phases (for instance,...
BackgroundObesity increases the risk of cancer death among postmenopausal women with estrogen receptor–positive (ER+) breast cancer, but direct evidence for mechanisms is lacking. The purpose this study to demonstrate mediating epidemiologic phenomenon.
Hyperpolarized [1-(13)C]-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are highly transient their spatial distribution varies continuously over observable lifetime. Therefore, new approaches needed to ensure optimal measurement under these circumstances. Constrained reconstruction algorithms can integrate prior...
Extensive reprogramming of cellular energy metabolism is a hallmark cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show that 14-3-3σ regulates cancer and protects cells from tumorigenic transformation. opposes tumour-promoting programmes by enhancing c-Myc poly-ubiquitination subsequent degradation. demonstrates suppressive impact on glycolysis, glutaminolysis, mitochondrial biogenesis other major...
p53 plays an important role in mitotic checkpoint, but what its is remains enigmatic. Aurora A a Ser/Thr kinase involved correcting progression of mitosis. Here, we show that negative regulator for A. We found deficiency leads to elevation. Ectopic expression or DNA damage-induced can suppress the Mechanistic studies through both transcriptional and posttranslational regulation. knockdown cancer cells reduces level p21, which, turn, increases activity CDK2 followed by induction Rb1...
Constitutive photomorphogenic 1 (COP1) is a p53-targeting E3 ubiquitin ligase that downregulated by DNA damage through mechanisms remain obscure. Here, we report COP1 not following in 14-3-3σ null cells, implicating as critical regulator the response of to damage. We also identified 14-3-3σ, p53 target gene product, interacted with and controlled protein stability after Mechanistic studies revealed enhanced self-ubiquitination, thereby preventing COP1-mediated ubiquitination, degradation,...
Adrenocortical carcinoma is a rare malignancy with poor prognosis and limited response to chemotherapy. Hepatocyte growth factor (HGF) its receptor cMET augment cancer resistance chemotherapy, but their role in adrenocortical has not been examined. In this study, we investigated the association between HGF/cMET expression hallmarks of carcinoma. Transcriptomic immunohistochemical analyses indicated that increased human samples was positively associated cancer-related biologic processes,...
FBXW7, a component of E3 ubiquitin ligase, plays an important role in mitotic checkpoint, but its remains unclear. Aurora B is checkpoint kinase that pivotal mitosis by ensuring correct chromosome segregation and normal progression through mitosis. Whether FBXW7 are coordinately regulated during not known. Here, we show negative regulator for B. Ectopic expression can suppress the Accordingly, deficiency leads to elevation. Mechanistic studies all isoforms regulators ubiquitination-mediated...
HER2/neu oncogene is frequently deregulated in cancers, and the (PI3K)-Akt signaling one of major pathways mediating oncogenic signal. p57Kip2, an inhibitor cyclin-depependent kinases, pivotal regulating cell cycle progression, but its upstream regulators remain unclear. Here we show that HER2-Akt axis linked to p57Kip2 regulation, Akt a negative regulator p57Kip2. Ectopic expression can decrease while inhibition leads stabilization. Mechanistic studies interacts with causes cytoplasmic...
Abstract Forkhead‐Box Class O 4 (FOXO4) is involved in critical biological functions, but its response to EGF‐PKB/Akt signal regulation not well characterized. Here, it reported that FOXO4 levels are downregulated EGF treatment, with concurrent elevation of COP9 Signalosome subunit 6 (CSN6) and E3 ubiquitin ligase constitutive photomorphogenic 1 (COP1) levels. Mechanistic studies show CSN6 binds regulates stability through enhancing the activity COP1, COP1 directly interacts a VP motif on...
Type II diabetes mellitus (DM2) is a significant risk factor for cancers, including breast cancer. However, proper diabetic cancer mouse model not well-established treatment strategy design. Additionally, the precise signaling pathways that regulate growth remain unresolved. In present study, we established suitable and demonstrated pathogenic role of on progression.We successfully generated transgenic human epidermal receptor 2 positive (Her2+ or ERBB2) with DM2 by crossing leptin mutant...
HER2/neu oncogene is frequently overexpressed in various types of cancer, and the (PI3K)-Akt signaling pathway often activated HER2-overexpressing cancer cells. CSN6, subunit 6 COP9 signalosome complex, pivotal regulating MDM2 to destabilize p53, but its upstream regulators remain unclear. Here we show that HER2-Akt axis linked CSN6 regulation, Akt a positive regulator CSN6. Ectopic expression can increase CSN6; accordingly, inhibition leads destabilization. Mechanistic studies causes...
The COP9 signalosome subunit 6 (CSN6), which is involved in ubiquitin-mediated protein degradation, overexpressed many types of cancer. CSN6 critical causing p53 degradation and malignancy, but its target cell cycle progression not fully characterized. Constitutive photomorphogenic 1 (COP1) an E3 ubiquitin ligase associating with to regulate important proteins for growth. p27 a G1 CDK inhibitor regulation, upstream regulators are Here, we show that the CSN6-COP1 link regulating p27(Kip1)...
SKP2, an F-box protein of the SCF type E3 ubiquitin ligase complex, plays important function in driving tumorigenesis through destruction numerous tumor-suppressive proteins. Besides its critical role cell cycle regulation, proto-oncogenic functions SKP2 have also been shown a regulation-independent manner. Therefore, uncovering novel physiological upstream regulators signaling pathways would be essential to retard aggressive malignancies. Here, we report that elevation and EP300...