A5100727834- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Spinal Fractures and Fixation Techniques
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Medical Imaging and Analysis
- Histone Deacetylase Inhibitors Research
- Inflammatory mediators and NSAID effects
- Cervical and Thoracic Myelopathy
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Natural product bioactivities and synthesis
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Scoliosis diagnosis and treatment
- Medicinal Plant Pharmacodynamics Research
- RNA modifications and cancer
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- Osteoarthritis Treatment and Mechanisms
- Spaceflight effects on biology
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2015-2025
Blood Center of Zhejiang Province
2019-2024
South China Agricultural University
2024
Shanghai Municipal Center For Disease Control Prevention
2017-2024
The First People's Hospital of Xiaoshan District, Hangzhou
2024
Hangzhou Normal University
2024
Shangrao Normal University
2021-2024
Center for Disease Control
2024
First Affiliated Hospital of Wenzhou Medical University
2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially identified in China and currently worldwide dispersed, resulting the disease 2019 (COVID-19) pandemic. Notably, COVID-19 is characterized by systemic inflammation. However, potential mechanisms of “cytokine storm” are still limited. In this study, fourteen peripheral blood samples from patients ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>10</mn> </math> ) healthy donors...
Background: Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial ventricular cardiomyocytes (aCMs vCMs). The mechanisms responsible for these remain largely undefined. Methods: We nominated candidate enhancers (CSEs) by determining genome-wide occupancy of 7 key cardiac transcription factors (GATA4, MEF2A, MEF2C, NKX2-5, SRF, TBX5, TEAD1) coactivator P300 in atria ventricles. Candidate were tested using an adeno-associated...
Traumatic spinal cord injury (SCI) causes severe central nervous system damage. M2 macrophages within the lesion are crucial for SCI recovery. Our previous research revealed that transfected with magnetotactic bacteria–derived Mms6 gene can resist ferroptosis and enhance To address limitations of macrophage transplantation, we developed lipid nanoparticles (LNPs) encapsulating mRNA targeting ( mRNA-PS/LNPs). The efficiency therapeutic effect these LNPs in mice were evaluated. Intravenous...
In the era of personalized medical practice, understanding genetic basis patient-specific adverse drug reaction (ADR) is a major challenge. Clozapine provides effective treatments for schizophrenia but its usage limited because life-threatening agranulocytosis. A recent high impact study showed necessity moving clozapine to first line drug, thus identifying biomarkers drug-induced agranulocytosis has become important. Here we report methodology termed as antithesis chemical-protein...
Abstract Our objective was to identify suitable reference genes in serum miRNA for normalization and screen potential new biomarkers osteoporosis diagnosis by a systematic study. Two types of models were used like as mechanical unloading estrogen deficiency. Through large-scale screening using microarray, qPCR validation statistical algorithms, we first identified miR-25-3p gene both type osteoporosis, which also showed stability during the differentiation processes osteoblast osteoclast....
Inflammatory infiltration and bone destruction are important pathological features of rheumatoid arthritis (RA), which originate from the disturbed niche macrophages. Here, we identified a niche-disrupting process in RA: due to overactivation complement, barrier function VSIg4+ lining macrophages is disrupted mediates inflammatory within joint, thereby activating excessive osteoclastogenesis resorption. However, complement antagonists have poor biological applications superphysiologic dose...
Abstract Yes‐associated protein 1 (YAP1) is a transcriptional coactivator and negative regulator of the Hippo pathway. It regulates diverse cellular processes, such as cell proliferation, contact inhibition, tissue size. However, role YAP1 in intervertebral disc degeneration (IDD) remains elusive. Here, we demonstrated that was activated by Interleukin 6 (IL‐6) through tyrosine phosphorylation nucleus pulposus cells (NP cells). Overexpression decreased Sox‐9, Col‐II, aggrecan expression,...
Background: Biochanin A and formononetin are O-methylated isoflavones that isolated from the root of Astragalus membranaceus, have antitumorigenic effects. Our previous studies found triggered growth-inhibitory apoptotic activities in MCF-7 breast cancer cells. We performed vivo vitro to further investigate potential effect biochanin promoting cell proliferation estrogen receptor (ER)-positive cells, elucidate underlying mechanisms. Methods: ERα-positive cells (T47D, MCF-7) were treated with...
Emerging evidence indicates that circRNAs are broadly expressed in osteosarcoma (OS) cells and play a crucial role OS progression. Recently, cancer-specific circRNA circPRKAR1B has been identified by high-throughput sequencing is recorded publicly available databases. Nevertheless, the detailed functions underlying mechanisms of remains poorly understood. By functional experiments, we found enhanced cell proliferation, migration, promotes epithelial-mesenchymal transition (EMT). Mechanistic...
Abstract Background This study aimed to investigate functions of GLP-1R agonist by liraglutide (LIRA) and revealing the mechanism related AGEs/RAGE in chondrocytes. Methods To illustrate potential effect on AGEs induced chondrocytes, chondrocytes were administrated with LIRA inhibitor exendin. Inflammatory factors assessed using ELISA. Real-time PCR was used evaluate catabolic activity MMPs ADAMTS mRNA level, as well anabolic (aggrecan collagen II). RAGE expression investigated Western...
Constitutive photomorphogenic 1 (COP1) is a p53-targeting E3 ubiquitin ligase that downregulated by DNA damage through mechanisms remain obscure. Here, we report COP1 not following in 14-3-3σ null cells, implicating as critical regulator the response of to damage. We also identified 14-3-3σ, p53 target gene product, interacted with and controlled protein stability after Mechanistic studies revealed enhanced self-ubiquitination, thereby preventing COP1-mediated ubiquitination, degradation,...
Background Context There are few comparisons of Modic changes (MCs) in the lumbar and cervical spine. Purpose Compare prevalence MCs spine, determine how MC depends on spinal pain, age, disc degeneration, level, presence or absence kyphosis. Study Design Retrospective clinical survey. Materials Methods Magnetic resonance images (MRIs) were compared from five patient groups: 1. 1223 patients with low-back pain/radiculopathy only; 2. 1023 neck 3. 497 concurrent symptoms; 4. 304 asymptomatic...
Background and Objective: The intervertebral disc degeneration changes paraspinal muscles are believed to be risk factors for lumbar degenerative spondylolisthesis (LDS). But there is limited quantitative information about this progressio
Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, influencing levels of free fatty acids which could impair cell metabolism. This study aims to establish metabolic factors in obesity-related IDD independent mechanical loading. In clinical study, we retrospectively reviewed 128 volunteers (73 males, 55 females, aged 29-88 years) and compared their grades with such as body weight, BMI, serum lipid levels. Clinically, the group showed increased age, BMI...