A5018189058- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Pelvic and Acetabular Injuries
- Spondyloarthritis Studies and Treatments
- Gear and Bearing Dynamics Analysis
- Advanced Measurement and Metrology Techniques
- Scoliosis diagnosis and treatment
- Anesthesia and Pain Management
- Industrial Vision Systems and Defect Detection
- Advanced Measurement and Detection Methods
- Manufacturing Process and Optimization
- Kruppel-like factors research
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Infectious Diseases and Tuberculosis
- Tissue Engineering and Regenerative Medicine
- Metallurgy and Material Forming
- Bone and Joint Diseases
- Geomechanics and Mining Engineering
- Spinal Hematomas and Complications
- Polymer Science and PVC
- Optical measurement and interference techniques
Zhejiang University
2014-2024
Sir Run Run Shaw Hospital
2014-2024
Blood Center of Zhejiang Province
2019-2024
Ningbo Medical Center Lihuili Hospital
2024
Institute of Science and Technology
2024
National Natural Science Foundation of China
2016-2017
National Engineering Research Center for Compounding and Modification of Polymer Materials
2011-2013
Taiyuan University of Technology
2012
Yong-in Songdam College
2012
Shanghai Jiao Tong University
2011
A retrospective survey on 85 consecutive patients with primary single-level lumbar disc herniation (LDH).To investigate associations between Modic changes (MCs) and the likelihood of resorption herniated intervertebral discs.Spontaneous LDH has been demonstrated, whereas mechanisms are unclear. MCs closely associated degeneration, but research focusing their association spontaneous not specifically investigated.Eighty-five (52 males, 33 females, aged 20-66 yr) were included. Patients'...
Abstract Yes‐associated protein 1 (YAP1) is a transcriptional coactivator and negative regulator of the Hippo pathway. It regulates diverse cellular processes, such as cell proliferation, contact inhibition, tissue size. However, role YAP1 in intervertebral disc degeneration (IDD) remains elusive. Here, we demonstrated that was activated by Interleukin 6 (IL‐6) through tyrosine phosphorylation nucleus pulposus cells (NP cells). Overexpression decreased Sox‐9, Col‐II, aggrecan expression,...
To review and analyze cage migration related risk factors in patients who have undergone transforaminal lumbar interbody fusion (TLIF).A retrospective study was conducted to the complications of 512 had a TLIF procedure from January 2010 June 2011 five spinal centers. In all, 263 men 249 women with mean age 54.7 years were included. All followed up at 3, 6 12 months after procedure. The clinical outcomes evaluated by visual analogue scores, Oswestry disability index, plain radiography...
Background Context There are few comparisons of Modic changes (MCs) in the lumbar and cervical spine. Purpose Compare prevalence MCs spine, determine how MC depends on spinal pain, age, disc degeneration, level, presence or absence kyphosis. Study Design Retrospective clinical survey. Materials Methods Magnetic resonance images (MRIs) were compared from five patient groups: 1. 1223 patients with low-back pain/radiculopathy only; 2. 1023 neck 3. 497 concurrent symptoms; 4. 304 asymptomatic...
Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, influencing levels of free fatty acids which could impair cell metabolism. This study aims to establish metabolic factors in obesity-related IDD independent mechanical loading. In clinical study, we retrospectively reviewed 128 volunteers (73 males, 55 females, aged 29-88 years) and compared their grades with such as body weight, BMI, serum lipid levels. Clinically, the group showed increased age, BMI...
Abstract Objective To investigate the relationship between Modic changes (MCs) and recurrent lumbar disc herniation (rLDH) that herniated component rLDH following percutaneous endoscopic discectomy (PELD). Methods We included 102 (65 males, 37 females, aged 20–66 years) inpatients who underwent PELD from August 2013 to 2016. All patients CT MRI preoperatively. The presence type of were assessed. During surgery, each patient was classified into two groups: nucleus pulposus group hyaline...
Retrospective clinical case series.To investigate the risk factors for intraoperative endplate violations and delayed cage subsidence after oblique lateral interbody fusion (OLIF) surgery. Secondly, to examine whether low Hounsfield unit (HU) values at different regions of are associated with violation or subsidence.61 patients (aged 65.1 ± 9.5 years; 107 segments) who underwent OLIF without posterior instrumentation from May 2015 April 2019 were retrospectively studied. Intraoperative was...
Intervertebral disc degeneration (IVDD) has been known as a highly prevalent and disabling disease, which is one of the main causes low back pain disability. Unfortunately, there no effective cure to treat this formidable surgical interventions are typically applied. Herein, we report that local administration nitric oxide (NO)-releasing micellar nanoparticles can efficiently IVDD associated with Modic changes in rat model established by infection Cutibacterium acnes (C. acnes). By covalent...
Abstract Lipid metabolism plays a crucial role in maintaining bone homeostasis, particularly osteoclasts (OCs) formation. Here, we found that the expression level of FATP2, transporter for long-chain and very-long-chain fatty acids, was significantly upregulated during OC differentiation marrow mice fed high-fat diet (HFD). Notably, use FATP2 siRNA or specific inhibitor (Lipofermata) resulted significant inhibition differentiation, while only slightly affecting osteoblasts. In pathological...
This paper designs a synchronous automatic positioning straight cylindrical gear visual measuring instrument, where the internal gears are main measurement objects and detailed profile analysis is conducted. Compared with traditional contact instruments, this design not only has advantages of fast speed high accuracy, but also shows significant in processing complex shape tooth profile. The components designed include high-precision rotating platform mechanism, transmission mechanisms along...
In response to the demand for fast and high-precision measurement of small medium-sized module spur gears, this paper develops a machine vision based instrument gears. The system includes two parts: mechanical structure measuring visual device. Among them, selection angle indexing plates, fixture design strength verification, column marble platform as well X, Y, Z axis position adjustment mechanisms; device includes: camera lens, CCD camera, LED backlight, data acquisition card. On basis,...
ARM exoskeleton robot is widely used in rehabilitation medicine, industrial production, military, disability, aerospace and scientific research experiments, plays an important role. In this paper, arm with multiple joints moving independently designed, which aimed at the human upper limb movement, such as forward bending, backward extending, adduction right bending limit of joints, design provides user auxiliary strength a degree upper-body flexibility, can be for reference to other...
// Xianfeng Lin 1,2,* , Xiangqian Fang Qiang Wang Zhijun Hu 1,2 Kai Chen 3 Zhi Shan 1 Shuai Jiying Jian Mo Jianjun Ma Wenbing Xu An Qin 4 and Shunwu Fan Department of Orthopaedic Surgery, Sir Run Shaw Hospital, Medical College Zhejiang University, Hangzhou, China 2 Institute Micro-Invasive Surgery the First Affiliated Hospital Wenzhou College, Wenzhou, Orthopedics, Shanghai Key Laboratory Orthopedic Implant, Ninth People's Jiaotong University School Medicine, Shanghai, * These authors have...
Background: Modic changes (inflammatory-like visible on magnetic resonance imaging [MRI] scans of a vertebral end plate) are common and associated with low back pain, but their origin is unclear. To our knowledge, there have been no previous in vivo animal models changes. We hypothesized that may be related to Propionibacterium acnes . Methods: Ten New Zealand White rabbits were injected percutaneously 1 mL P. (1.6 × 10 7 colony forming units/mL) into the subchondral bone superior L4-L5...
In order to reasonable plan the spatial layout of an industrial robot feeding and loading inspection production line based on visual measurement principles improve efficiency inspection, this paper proposes a structural design workstation principles. The content includes: designing structure arm, wrist, lower upper lumbar seat, base robotic selecting end effector arm. Analyze overall workstation, select conveying mechanism, three jaw chuck. On basis, briefly describe working arm workstation....