A5100681956- Cancer-related molecular mechanisms research
- Adsorption and biosorption for pollutant removal
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Nanomaterials for catalytic reactions
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Insect and Pesticide Research
- Photosynthetic Processes and Mechanisms
- Epigenetics and DNA Methylation
- Plant biochemistry and biosynthesis
- Lipid metabolism and biosynthesis
- Plant Molecular Biology Research
- Cancer-related gene regulation
- Heat shock proteins research
- Cholesterol and Lipid Metabolism
- Genomics and Phylogenetic Studies
- Plant Stress Responses and Tolerance
- Advanced biosensing and bioanalysis techniques
- Soybean genetics and cultivation
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- 14-3-3 protein interactions
- Legume Nitrogen Fixing Symbiosis
Shanghai Public Health Clinical Center
2022-2025
Wenzhou Medical University
2025
Dongyang People's Hospital
2025
Tianjin University of Traditional Chinese Medicine
2023-2024
Hainan Medical University
2022-2024
Shandong University
2013-2024
Zhejiang University
2021-2024
Instituut voor Landbouw en Visserijonderzoek
2024
Zhengzhou University of Science and Technology
2023-2024
China University of Mining and Technology
2024
Hypoxia is a key feature of breast cancer, which affects cancer development, metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could participate in progression hypoxia regulation. This study aimed to investigate the role circRNA differentially expressed normal cells neoplasia domain containing 4C (circDENND4C) under hypoxia. Forty-three patients with were involved this study. Breast cell lines MDA-MB-453 SK-BR-3 cultured (1% O2) for experiments vitro. The...
Phosphorus (P) is an essential macronutrient, and important component of plant metabolism. However, little known about the effects low P availability on absorption, photosynthetic electron transport chain, antioxidant system in cotton. This study used cotton genotypes (sensitive FJA DLNTDH tolerant BX014 LuYuan343) with contrasting low-P tolerance a hydroponic experiment under 15 µM, 50 500 μM concentrations. The results showed that reduced development leaf area, shoot length, dry weight...
Abstract N6-methyladenosine (m6A) is one of widespread post-transcriptional mRNA modifications in eukaryotes and the m6A modification plays critical roles various human cancers. However, role m6A-binding proteins cancer metabolism remains elusive. Here, we report that YTH domain family 2 (YTHDF2) upregulated lung tissues, promotes cell growth enhances pentose phosphate pathway (PPP) flux, which crucial for tumor growth. Mechanistically, YTHDF2 directly binds to site 6-phosphogluconate...
Tanshinones are health-promoting diterpenoids found in Salvia miltiorrhiza and have wide applications. Here, SmGGPPS (geranylgeranyl diphosphate synthase) SmDXSII (1-deoxy-d-xylulose-5-phosphate were introduced into hairy roots of S. miltiorrhiza. Overexpression produces higher levels tanshinone than control single-gene transformed lines; production the double-gene line GDII10 reached 12.93 mg/g dry weight, which is highest content that has been achieved through genetic engineering....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially identified in China and currently worldwide dispersed, resulting the disease 2019 (COVID-19) pandemic. Notably, COVID-19 is characterized by systemic inflammation. However, potential mechanisms of “cytokine storm” are still limited. In this study, fourteen peripheral blood samples from patients ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>n</mi> <mo>=</mo> <mn>10</mn> </math> ) healthy donors...
Resistance to tamoxifen (TAM) frequently occurs in the treatment of estrogen receptor positive (ER+) breast cancer. Accumulating evidences indicate that transcription factor HOXB13 is great significance TAM resistance. However, regulation TAM-resistant cancer remains largely unexplored. Here, we were interested potential effect HBXIP, an oncoprotein involved acceleration progression, on modulation resistance cancer.The Kaplan-Meier plotter database and GEO dataset used analyze association...
Copper chaperone for superoxide dismutase (CCS) is a critical component of oxidation-reduction system and functions as potential tumor promoter in several cancers. However, the function clinical significance CCS breast cancer remains unclear. Here, we found was highly expressed cancer, where it promoted cell proliferation migration. Suppression expression sufficient to attenuate phosphorylation level ERK1/2, increase accumulation reactive oxygen species (ROS). Mechanistically, that knockdown...
Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein arginine methyltransferase 6 (PRMT6) highly expressed in cancer required for cell metabolism, tumorigenicity, cisplatin response PRMT6 regulated oxidative pentose phosphate pathway (PPP) flux glycolysis human by increasing activity 6-phospho-gluconate dehydrogenase (6PGD) α-enolase (ENO1). Furthermore,...
Lung inflammation indicated by 18F-labeled fluorodeoxyglucose (FDG) in patients with tuberculosis is associated disease severity and relapse risk upon treatment completion. We revealed the heterogeneity intercellular crosstalk lung tissues 18F-FDG avidity adjacent uninvolved from 6 single-cell RNA-sequencing. Tuberculous lungs had an influx of regulatory T cells (Treg), exhausted CD8 cells, immunosuppressive myeloid conventional DC, plasmacytoid neutrophils. Immune inflamed showed general...
In the frame of a bumble bee gut microbiota study, acetic acid bacteria (AAB) were isolated using combination direct isolation methods and enrichment procedures. MALDI-TOF MS profiling isolates comparison these profiles with established AAB species identified most as Asaia astilbis or 'Commensalibacter intestini', except for two (R-52486 LMG 28161(T)) that showed an identical profile. A nearly complete 16S rRNA gene sequence strain 28161(T) was determined highest pairwise similarity to...
Hepatitis B X-interacting protein (HBXIP) is an important oncoprotein that plays critical role in the development of cancer. In this study, we report HBXIP activates LIM-only 4 (LMO4), a transcriptional coregulatory protein, promotion cell proliferation. We observed messenger RNA (mRNA) expression levels were positively associated with those LMO4 clinical breast cancer tissues. further identified upregulated at promoter, mRNA and MCF-7 LM-MCF-7 lines. The cyclin D1 E, downstream effectors...
Novel Fe3O4@mTiO2@GO microspheres for the fast removal of Cr(VI) were synthesized by immobilizing a mesoporous TiO2 shell on surface magnetic Fe3O4 nanoparticles prior to binding with GO. The characterization results from FTIR, SEM, VSM and XRD showed that was successfully prepared large area good responsiveness. It shown sorption strongly dependent pH value contact time. As Cr-removal adsorbents, maximum capability 117.94 mg g−1. equilibrium adsorptions well-described Freundlich isotherm...
Silicon (Si) could alleviate the adverse effect of salinity in many crops, but cotton remains unclear. In this study, we evaluated role Si regulating salt stress tolerance by analyzing induced morpho-physiological changes. A hydroponic experiment was conducted using contrasting salt-tolerant genotypes (sensitive Z0102; tolerant Z9807) and four treatments (CK, control; CKSi, 0.4 mM Si; NaCl, 150 NaCl; NaClSi, NaCl+0.4 Si). The results showed that significantly enhanced net photosynthesis rate...
An acetic acid bacterium, strain LMG 27439(T), was isolated from fermenting lambic beer. The cells were Gram-stain-negative, motile rods, catalase-positive and oxidase-negative. Analysis of the 16S rRNA gene sequence revealed closely related to Acetobacter okinawensis (99.7 % similarity with type this species), A. ghanensis (99.6 %), syzygii fabarum (99.4 %) lovaniensis (99.2 %). DNA-DNA hybridization strains these species moderate values (31-45 Strain 27439(T) unable grow on glycerol or...
Magnetic cyclodextrin/graphene oxide (MCGO) materials were fabricated through a facile chemical route and their application as excellent adsorbents for methylene blue (MB) was also demonstrated. The results from FTIR, SEM, TEM, VSM XRD showed that MCGO prepared. large saturation magnetization (51.13 emu g−1) of the synthesized nanoparticles allows fast separation liquid suspension. demonstrate extremely MB-removal wastewater with high removal efficiency within 50 min. adsorption kinetics,...
Five acetic acid bacteria isolates, awK9_3, awK9_4 ( = LMG 27543), awK9_5 28092), awK9_6 and awK9_9, obtained during a study of micro-organisms present in traditionally produced kefir, were grouped on the basis their MALDI-TOF MS profile with 1530 1531(T), two strains currently classified as members genus Acetobacter. Phylogenetic analysis based nearly complete 16S rRNA gene sequences well concatenated partial housekeeping genes dnaK, groEL rpoB indicated that these isolates representatives...