A5103160087- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- RNA Research and Splicing
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Peroxisome Proliferator-Activated Receptors
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS Research and Interventions
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Nanocluster Synthesis and Applications
- Carbon and Quantum Dots Applications
- Biosensors and Analytical Detection
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Advanced Photocatalysis Techniques
- MicroRNA in disease regulation
Zhejiang Chinese Medical University
2025
Wuhan University of Technology
2021-2025
Wuhan University of Science and Technology
2022-2024
Texas A&M University
2021-2024
Chinese Academy of Sciences
2022-2024
Second Affiliated Hospital of Jilin University
2024
Wuyi University
2024
Shanghai Institute of Applied Physics
2024
Xinjiang Medical University
2023-2024
Fifth Affiliated Hospital of Xinjiang Medical University
2023-2024
The fat-derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons hypothalamic arcuate nucleus. To study intrinsic these their responses to leptin, we generated mice that express distinct green fluorescent proteins two neuronal types. Leptin-deficient (ob/ob) differed from wild-type numbers excitatory inhibitory synapses postsynaptic currents onto neurons. When was delivered systemically ob/ob mice, synaptic density...
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from of deficient ob/ob mice. ObR expressed many tissues, including brain, and relative importance leptin's effects on central versus peripheral sites has not been resolved. To address this, we generated mice neuron-specific (ObR(SynI)KO) hepatocyte-specific (ObR(Alb)KO) disruption ObR. Among ObR(SynI)KO mice, extent obesity was negatively correlated level hypothalamus those animals...
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from of deficient ob/ob mice. ObR expressed many tissues, including brain, and relative importance leptin’s effects on central versus peripheral sites has not been resolved. To address this, we generated mice neuron-specific (ObRSynIKO) hepatocyte-specific (ObRAlbKO) disruption ObR. Among ObRSynIKO mice, extent obesity was negatively correlated level hypothalamus those animals lowest...
We report the development of a pseudorabies virus that can be used for retrograde tracing from selected neurons. This encodes green fluorescent protein marker and replicates only in neurons express Cre recombinase synaptic contact with originally infected cells. The was injected into arcuate nucleus mice those neuropeptide Y or leptin receptor. Sectioning brains revealed these receive inputs other regions hypothalamus, as well amygdala, cortex, brain regions. These data suggest higher...
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in pharyngeal swab, blood, and anal swab detected by real-time PCR clinical lab. Unexpectedly, 2109-nCoV RNA was readily blood (6 of 57 patients) swabs (11 28 patients). Importantly, all 6 patients with detectable viral cohort progressed to severe symptom stage, indicating a strong correlation serum disease severity (p-value = 0.0001). Meanwhile, 8 11 annal virus-positive stage....
Abstract HULC is a long noncoding RNA overexpressed in hepatocellular carcinoma (HCC), but its functional contributions this setting have not been determined. In study, we explored the hypothesis that contributes to malignant development by supporting abnormal lipid metabolism hepatoma cells. modulated deregulation of HCC activating acyl-CoA synthetase subunit ACSL1. Immunohistochemical analysis tissue microarrays revealed approximately 77% (180/233) tissues were positive for Moreover, mRNA...
In this paper, we reported a ZnO quantum dots-based pH-responsive drug delivery platform for intracellular controlled release of drugs. Acid-decomposable, luminescent aminated dots (QDs) were synthesized as nanocarriers with ultrasmall size (∼3 nm). The dicarboxyl-terminated poly(ethylene glycol) (PEG) had been introduced to NH2–ZnO QDs, which rendered it stable under physiological fluid. Moreover, targeting ligand, hyaluronic acid (HA), was conjugated QDs specifically binding the...
The melanocortin-4 receptor (MC4-R) is an important regulator of energy homeostasis, and evidence suggests that MC4-R-expressing neurons are downstream targets leptin action. MC4-Rs broadly expressed in the CNS, distribution MC4-R mRNA has been analyzed most extensively rat. However, relatively little known concerning chemical profiles neurons. extent to which central melanocortins act presynaptically or postsynaptically on also unknown. To address these issues, we have generated a...
The autonomic nervous system regulates fuel availability and energy storage in the liver, adipose tissue, other organs; however, molecular components of this neural circuit are poorly understood. We sought to identify populations that project from CNS indirectly through multisynaptic pathways liver epididymal white fat mice using pseudorabies virus strains expressing different reporters together with BAC transgenesis immunohistochemistry. Neurons common both circuits were identified...
Abstract c-Myc is regarded as a transcription factor, but the basis for its function remains unclear. Here, we define long noncoding RNA (lncRNA)/protein complex that mediates transcriptional activation by in breast cancer cells. Among 388 target genes human MCF-7 cells, found their promoters could be occupied oncoprotein HBXIP. We confirmed HBXIP expression correlated with of cyclin A, eIF4E, and LDHA. RNAi-mediated silencing abolished c-Myc–mediated upregulation these genes....
Benefiting from the maximum atom-utilization efficiency and distinct structural features, single-atom catalysts open a new avenue for design of more functional catalysts, whereas their bioapplications are still in infancy. Due to advantages, platinum single atoms supported by cadmium sulfide nanorods (Pt SAs-CdS) synthesized build an ultrasensitive photoelectrochemical (PEC) biosensing platform. With decoration Pt SAs, PEC signal CdS is significantly boosted. Furthermore, theory calculations...
// Xiaoli Cai 1 , Can Cao Jiong Li 2 Fuquan Chen Shuqin Zhang Bowen Liu Weiying Xiaodong and Lihong Ye State Key Laboratory of Medicinal Chemical Biology, Department Biochemistry, College Life Sciences, Nankai University, Tianjin 300071, China Cancer Research, Correspondence to: Ye, email: yelihong@nankai.edu.cn Zhang, zhangxd@nankai.edu.cn zhwybao@nankai.edu.cn Keywords: TNF-α, HBXIP, STAT3, growth, breast cancer Received: November 01, 2016 Accepted: March 15, 2017 Published: April 06,...
Inspired by the key role of coordination environment in catalytic activity enzymes, a rational design structure active sites at atom scale is expected to develop high-performance enzyme-like catalysts. Here, we simple model system involving pentacoordinated and tetracoordinated Fe–N–C single-atom catalysts (named NG-Heme G-Heme, respectively) investigate structure–activity relationships. with axial ligand-engineered Fe exhibits superior achieving goal vivid mimicking peroxidase. Experiments...
Enzyme immobilization plays an essential role in solving the problems of inherently fragile nature enzymes. Although prominent stability and reuse enzymes can be achieved by enzyme immobilization, their bioactivity catalytic efficiency will adversely affected. Herein, PdCu hydrogel nanozymes with a hierarchically porous structure were used to immobilize horseradish peroxidase (HRP) obtain PdCu@HRP. In addition improvement reusability, PdCu@HRP displayed synergistically enhanced activities...
The large-scale application of nanozymes remains a significant challenge owing to their unsatisfactory catalytic performances. Featuring unique electronic structure and coordination environment, single-atom provide great opportunities vividly mimic the specific metal center natural enzymes achieve superior enzyme-like activity. In this study, spin state engineering Fe (FeNC) is employed enhance peroxidase-like Pd nanoclusters (PdNC) are introduced into FeNC, whose electron-withdrawing...
Neurotoxicity of organophosphate compounds (OPs) can catastrophically cause nervous system injury by inhibiting acetylcholinesterase (AChE) expression. Although artificial systems have been developed for indirect neuroprotection, they are limited to dissociating P-O bonds eliminating OPs. However, these failed overcome the deactivation AChE. Herein, we report our finding that Al3+ is engineered onto nodes metal-organic framework synthesize MOF-808-Al with enhanced Lewis acidity. The...
To enhance the antibacterial efficacy of tildipirosin against Staphylococcus aureus (S.A.) infections, optimized solid lipid nanoparticles loaded with (SLN-TD) were developed, using docosanoic acid (DA), octadecanoic (OA), hexadecanoic...
Resistance to tamoxifen (TAM) frequently occurs in the treatment of estrogen receptor positive (ER+) breast cancer. Accumulating evidences indicate that transcription factor HOXB13 is great significance TAM resistance. However, regulation TAM-resistant cancer remains largely unexplored. Here, we were interested potential effect HBXIP, an oncoprotein involved acceleration progression, on modulation resistance cancer.The Kaplan-Meier plotter database and GEO dataset used analyze association...