A5028355324- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Electrochemical sensors and biosensors
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Advanced Photocatalysis Techniques
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Heat Transfer and Boiling Studies
- Heat Transfer and Optimization
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Spinal Cord Injury Research
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Heat transfer and supercritical fluids
- Mitochondrial Function and Pathology
- Fluid Dynamics and Thin Films
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Quantum Dots Synthesis And Properties
- Luminescence and Fluorescent Materials
University of South China
2021-2025
Wuhan University of Science and Technology
2024-2025
Second Affiliated Hospital of Jilin University
2024
Central China Normal University
2017-2023
First Affiliated Hospital of University of South China
2021-2023
Intelligent Health (United Kingdom)
2020
Nanozyme/natural enzyme hybrid plays a vital role in biosensing, therapy, and catalysis owing to the integrated advantages selectivity of natural enzymes controllable catalytic activity nanozymes. Herein, Fe-MIL-88B-NH2 [(Fe-metal-organic framework (MOF)] with remarkable peroxidase-like activity, ultrahigh stability, high biocompatibility was utilized for immobilization glucose oxidase (GOx) via an amidation coupling reaction. On basis excellent Fe-MOF-GOx, cascade performed colorimetric...
Recently, in situ detection of hydrogen peroxide (H2O2) generated from live cells have caused tremendous attention, because it is great significance the control multiple biological processes. Herein, Fe–N–C single-atom nanozymes (Fe–N–C SAzymes) with intrinsic peroxidase-like activity were successfully prepared via high-temperature calcination using FeCl2, glucose, and dicyandiamide as precursors. The SAzymes FeNx active sites similar to natural metalloproteases, which can specifically...
Abstract Single‐atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe‐N‐C SACs can mimic oxidase by activating O 2 into reactive oxygen species, − • radicals. Taking advantages this property, single‐atom nanozymes (SAzymes) become a great impetus to develop novel biosensors. Herein, performance as...
Despite the breakthroughs of transition-metal catalysts in enzyme mimicking, fundamental investigation on design efficient nanozymes at atomic scale is still required for boosting their intrinsic activities to fill gaps from enzymes nanozymes. Herein, we developed a universal salt-template strategy fabrication atomically dispersed Fe atoms ultrathin nitrogen-doped carbon nanosheets characterized by dramatically high concentration 13.5 wt %. The proposed Fe-N-C with densely isolated FeN4...
Design of highly active carbon nanozymes and further establishment ultrasensitive biosensors remain a challenge. Herein, hierarchically porous with sulfur (S)/nitrogen (N) codoping (SNC) were developed. Compared N-doped (NC) nanozymes, SNC have smaller Michaelis–Menten constant higher specific activities, demonstrating that the S-doping in could not only enhance their affinity toward substrates but also improve catalytic performance. These results may be caused by synergistic effect...
Abstract Nanomaterials with enzyme‐like activities, coined nanozymes, have been researched widely as they offer unparalleled advantages in terms of low cost, superior activity, and high stability. The complex structure composition nanozymes has led to extensive investigation their catalytic sites at an atomic scale, in‐depth understanding the biocatalysis occurring. Single‐atom catalysts (SACs), characterized by atomically dispersed active sites, provided opportunities for mimicking...
The urgent need for sensitive and accurate assays to monitor acetylcholinesterase (AChE) activity organophosphorus pesticides (OPs) arises from the imperative safeguard human health protect ecosystem. Due its cost-effectiveness, ease of operation, rapid response, nanozyme-based colorimetry has been widely utilized in determination AChE OPs. However, rational design nanozymes with high specificity remains a great challenge. Herein, trace amount Bi-doped core–shell Pd@Pt mesoporous nanospheres...
Abstract Although nanozymes have been widely developed, accurate design of highly active sites at the atomic level to mimic electronic and geometrical structure enzymes exploration underlying mechanisms still face significant challenges. Herein, two functional groups with opposite electron modulation abilities (nitro amino) were introduced into metal–organic frameworks (MIL-101(Fe)) tune atomically dispersed metal thus regulate enzyme-like activity. Notably, functionalization nitro can...
Due to porous nanostructure and polydopamine-induced interfacial electron transfer effects, Au hydrogel nanozyme exhibits enhanced glucose oxidase-like peroxidase-like activities, with a biomimetic cascade catalysis.
Benefiting from the maximum atom-utilization efficiency and distinct structural features, single-atom catalysts open a new avenue for design of more functional catalysts, whereas their bioapplications are still in infancy. Due to advantages, platinum single atoms supported by cadmium sulfide nanorods (Pt SAs-CdS) synthesized build an ultrasensitive photoelectrochemical (PEC) biosensing platform. With decoration Pt SAs, PEC signal CdS is significantly boosted. Furthermore, theory calculations...
The rational construction of advanced sensing platforms to sensitively detect H2O2 produced by living cells is one the challenges in both physiological and pathological fields. Owing extraordinary catalytic performances similar metal coordination natural metalloenzymes, single atomic site catalysts (SASCs) with intrinsic peroxidase (POD)-like activity have shown great promise for detection. However, there still exists an obvious gap between them enzymes because challenge rationally...
Although single-atom catalysts with high enzyme-like activities have been found, the rational design of highly active peroxidase (POD)-like nanozymes is still a formidable challenge. Herein, POD-like were synthesized through loading Pt clusters on Fe (FeSA–PtC) nanozymes. The activity FeSA–PtC enhanced 4.5-fold and 7-fold, in comparison to that FeSA PtC nanozymes, respectively, which attributed unexpected synergistic effect between single atoms clusters. Based outstanding cascade signal...
Enzyme immobilization plays an essential role in solving the problems of inherently fragile nature enzymes. Although prominent stability and reuse enzymes can be achieved by enzyme immobilization, their bioactivity catalytic efficiency will adversely affected. Herein, PdCu hydrogel nanozymes with a hierarchically porous structure were used to immobilize horseradish peroxidase (HRP) obtain PdCu@HRP. In addition improvement reusability, PdCu@HRP displayed synergistically enhanced activities...
Improvement in the sensitivity and portability of enzyme-linked immunosorbent assay (ELISA) still faced huge challenges recently. Inspired by nanoprecipitation process for carrier-free nanodrug drug delivery systems, we developed an self-assembly strategy to prepare a kind all-inclusive allochroic 3,3′,5,5′-tetramethylbenzidine (TMB) nanoparticles developing improved ELISA (named TLISA). During TMB molecules, antibody as signal recognition units bovine serum albumin stabilizing agents could...
Though nanozymes are successfully applied in various areas, the increasing demands facilitate exploitation of possessing higher activity and more functions. Natural enzyme-linked receptors (ELRs) critical components for signal transductions vivo by expressing variations after binding with ligands. Inspired this, defect-engineered carbon nitrides (DCN) reported to serve as nanozyme-linked (NLRs). For one thing, cyano defects increase enzyme-like a factor 109.5. another, DCN-based NLRs...
Reactive oxygen species (ROS)-involved tumor therapeutic strategy, chemodynamic therapy (CDT), has attracted extensive research interest in the scientific community. However, effect of CDT is insufficient and unsustainable owing to limited endogenous H2 O2 level microenvironment. Here, peroxidase (POD)-like RuTe2 nanozyme with immobilization glucose oxidase (GOx) allochroic 3,3',5,5'-tetramethylbenzidine (TMB) molecule have been synthesized construct -GOx-TMB nanoreactors (RGT NRs) as...
A mitochondria-targeting and O<sub>2</sub>-evolving PDT nanoplatform based on 3D-dendritic MSNs was proposed for highly efficient cancer treatment.
Here, we demonstrated a pH-responsive nanocluster based on ZnO quantum dots (QDs) and investigated its potential in drug delivery with tumor-specific accumulation. The nanoclusters were composed of small single QDs by cross-linking dicarboxyl-terminated poly(ethylene glycol) (PEG), showing high stability biocompatibility physiological fluids. clustered capable loading large quantity doxorubicin (DOX) via complexation covalent interactions. After cellular uptake, the was efficiently released...