A5056545316- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Agricultural Productivity and Crop Improvement
- Wheat and Barley Genetics and Pathology
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Environmental and Agricultural Sciences
- Agriculture and Biological Studies
- Bacteriophages and microbial interactions
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Plant Taxonomy and Phylogenetics
- Agriculture, Soil, Plant Science
- interferon and immune responses
- RNA Interference and Gene Delivery
- Rice Cultivation and Yield Improvement
- Ruminant Nutrition and Digestive Physiology
- Systemic Lupus Erythematosus Research
- HIV, Drug Use, Sexual Risk
- Hepatitis Viruses Studies and Epidemiology
Guangzhou Eighth People's Hospital
2016-2025
Guangzhou Medical University
2016-2025
Inner Mongolia Agricultural University
2010-2024
Amgen (United States)
2008-2024
Hong Kong Standards and Testing Centre (China)
2024
University of Hong Kong
2011-2023
Beijing Hospital
2023
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
HKU-Pasteur Research Pole
2014-2023
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in pharyngeal swab, blood, and anal swab detected by real-time PCR clinical lab. Unexpectedly, 2109-nCoV RNA was readily blood (6 of 57 patients) swabs (11 28 patients). Importantly, all 6 patients with detectable viral cohort progressed to severe symptom stage, indicating a strong correlation serum disease severity (p-value = 0.0001). Meanwhile, 8 11 annal virus-positive stage....
BackgroundA novel variant of SARS-CoV-2, the Delta concern (VOC, also known as lineage B.1.617.2), is fast becoming dominant strain globally. We reported epidemiological, viral, and clinical characteristics hospitalized patients infected with VOC during local outbreak in Guangzhou, China.MethodsWe extracted epidemiological information pertaining to 159 cases across seven transmission generations between May 21 June 18, 2021. The whole chain was described. Kinetics viral load were compared a...
4005 Background: R is an investigational, fully human, monoclonal antibody to HGF/SF, the ligand of MET receptor. A double-blind, P-controlled, phase 2 study randomized 121 G/EGJ cancer pts 1:1:1 15 mg/kg + ECX (Arm A, n = 40), 7.5 B, 42), or P C, 39). OS and PFS improved with addition (Iveson et al, European Multidisciplinary Cancer Congress 2011; abstr 6.504). High tumor levels have been associated poor prognosis in G (Nakajima 1999;85:1894-1902). We explored pathway biomarkers identify...
Abstract Infection by many (+)RNA viruses is accompanied ER-expansion and membrane remodelling to form viral replication organelles, followed assembly secretion of progenies. We previously identified that virus-triggered lipophagy was critical for flaviviral assembly, driven the lipid droplet associated protein Ancient ubiquitin 1 (Aup1). A conjugating Ube2g2 functions as a co-factor Aup1 host dependency factor in our study. Here we characterized its function: Ube2g2-deficient cells...
Abstract To investigate the dynamic changes of Krebs von den Lungen‐6 (KL‐6) among patients with coronavirus disease 2019 (COVID‐19) and role KL‐6 as a noninvasive biomarker for predicting long‐term lung injury, clinical information laboratory tests 166 COVID‐19 were collected, correlation analysis between other parameters was conducted. There 17 (10.2%, 17/166) severe/critical 149 (89.8%, 149/166) mild in our cohort. Serum significantly higher than (median 898.0 vs. 451.2 U/ml, p <...
Osteoarthritis (OA) is a chronic and complicated degenerative disease for which there currently no effective treatment. Isoorientin (ISO) natural plant extract that has antioxidant activity could be used to treat OA. However, due lack of research, it not been widely used. In this study, we investigated the protective effects molecular mechanisms ISO on H2O2-induced chondrocytes, cell model Based RNA-seq bioinformatics, discovered significantly increased chondrocytes induced by H2O2, was...
Antiretroviral therapy (ART) efficiently reduces the morbidities and mortalities caused by HIV-1 infection prevents HIV epidemic. However, virologic failure (VF) occurs in some patients receiving ART experience, especially increases those with intermittent or persistent low-level viremia (LLV). The presence of drug resistance mutations (DRMs) LLV was a strong predictor subsequent VF. data on (DR) DRMs for infections at viral load (LLVL) are limited China.To monitor prevalence to evaluate...
The acceleration of osteoarthritis (OA) development by chondrocytes undergoing ferroptosis has been observed. Plumbagin (PLB), known for its potent antioxidant and anti-inflammatory properties, demonstrated promising potential in the treatment OA. However, it remains unclear whether PLB can impede progression temporomandibular joint (TMJOA) through regulation ferroptosis. study aims to investigate impact on TMJOA assess ability modulate inhibitory effects TMJOA.The utilized an vivo rat model...
Abstract Background National treatment guidelines of China evolving necessitates population-level surveillance transmitted drug resistance (TDR) to inform or update HIV strategies. Methods We analyzed the demographic, clinical, and virologic data obtained from people with (PWH) residing in 31 provinces who were newly diagnosed between 2018 2023. Evidence TDR was defined by World Health Organization list for mutations. Results Among 22 124 PWH protease reverse transcriptase sequences, 965...
The spectrophotometric assay for ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) was used to determine the rate of increase in Rubisco activity over time presence or absence activase. Polynomial approximations raw data were smooth out minor fluctuations spectrophotometer readings, and activase expressed as nanomoles activated per minute. This examine effects CO(2) inactive-Rubisco:ribulose complex (ER) on activase-catalyzed activation reaction. Double-reciprocal plots ER at several...
Abstract Despite timely immunization programs, and efficacious vaccines conveying protection against SARS-CoV-2 infection, breakthrough infections in vaccinated individuals have been reported. The Delta variant of concern (VOC) outbreak Guangzhou resulted local transmission non-vaccinated residents, providing a unique opportunity to study the protective effects inactivated infection. Here, we find that 2-dose group has similar peak viral titers comparable speeds RNA clearance but accelerated...
Reprogramming lipid metabolic pathways is a critical feature of activating immune responses to infection. However, how these reconfigurations occur poorly understood. Our previous screen identify cellular deubiquitylases (DUBs) activated during influenza virus infection revealed Usp25 as prominent hit. Here, we show that Usp25-deleted human lung epithelial A549 cells display >10-fold increase in pathogenic production, which was rescued upon reconstitution with the wild type but not...
Background The development of human immunodeficiency virus (HIV) drug resistance significantly impairs patients’ quality life. However, the HIV-1 patterns in central nervous system (CNS) have been poorly studied. Objective We aimed to compare genotypes and mutations (DRMs) derived from cerebrospinal fluid (CSF) plasma antiretroviral therapy (ART)-naive or -experienced patients. Methods matched CSF samples 59 patients with HIV were subjected proteinase (PR), reverse transcriptase (RT),...
Transmitted drug resistance (TDR) that affects the effectiveness of first-line antiretroviral therapy (ART) regimen is becoming prevalent worldwide. However, its prevalence and transmission among HIV-1 treatment-naïve patients in Guangdong, China are rarely reported. We aimed to comprehensively analyze TDR clusters infected persons before ART Guangdong.The were recruited between January 2018 December 2018. The pol region was amplified by reverse transcriptional PCR sequenced sanger...
Abstract The genetic recombination patterns and distribution of HIV-1 are valuable for elucidating the epidemic diversity HIV. Numerous circulating recombinant forms (CRFs) have recently emerged disseminated rapidly. In China, at least 32 CRFs been reported to account more than 80% all HIV infections. However, derived from CRF07_BC CRF55_01B lineages never recorded. Here, a novel third-generation CRF involving was identified in four HIV-1-infected patients Guangdong, who had no...