A5100425128- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hydraulic Fracturing and Reservoir Analysis
- Antimicrobial Peptides and Activities
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Drilling and Well Engineering
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Microwave Engineering and Waveguides
- Optical Coatings and Gratings
- Photonic and Optical Devices
- Ubiquitin and proteasome pathways
- Urinary Bladder and Prostate Research
- Fire dynamics and safety research
- Cancer, Hypoxia, and Metabolism
- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
Shanghai Jiao Tong University
2008-2025
Anhui Medical University
2008-2025
Army Medical University
2022-2025
Ganzhou People's Hospital
2024-2025
Nanchang University
2024-2025
Fuzhou University
2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Chengdu University of Traditional Chinese Medicine
2022-2024
Wuxi People's Hospital
2012-2024
Nickel cobalt sulfide (NiCo<sub>2</sub>S<sub>4</sub>) is a promising battery-type material for electrochemical energy storage.
Abstract Background The complex etiology and pathogenesis underlying Chronic Non-Bacterial Prostatitis (CNP), coupled with the existence of a Blood Prostate Barrier (BPB), contribute to lack specificity poor penetration most drugs. Emodin (EMO), potential natural compound for CNP treatment, exhibits commendable anti-inflammatory, anti-oxidant, anti-fibrosis properties but suffers from same problems as other Methods By exploiting recognition lactoferrin (LF) receptors that target intestinal...
Accumulating evidence demonstrates that the long non-coding RNA Growth Arrest-Specific 5 (Gas5) has practical significance in cancer progression and metastasis. However, its role function papillary thyroid carcinoma (PTC) remains unknown. In this study, we aimed to explore potential involvement of Gas5 carcinogenesis highlight emerging roles ceRNAs biological regulation PTC cells. The results suggested was markedly downregulated both tissues cell lines. Over-expression remarkably suppressed...
Anti-Ro52 antibody often co-occurs with anti-Jo1 in antisynthetase syndrome and their co-occurrence correlates a more aggressive clinical phenotype poorer prognosis. The strong association of anti-Ro52 anti-melanoma differentiation-associated protein-5 (anti-MDA5) has been indicated juvenile myositis. aim this study was to assess the significance cohort adult patients anti-MDA5-positive clinically amyopathic dermatomyositis interstitial lung disease (CADM-ILD).We assessed 83 consecutive...
Abstract Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 + DM) is an autoimmune condition associated with rapidly progressive interstitial lung disease and high mortality. The aetiology pathogenesis of MDA5 DM are still largely unknown. Here we describe the immune signatures via single-cell RNA sequencing, flow cytometry multiplex immunohistochemistry in peripheral B T cells affected tissue samples from one patient. We find strong antibody-secreting cell CD8...
Inositol polyphosphate 5-phosphatases can terminate downstream signalling of phosphatidylinositol-3 kinase; however, their biological role in the pathogenesis cancer is controversial. Here we report that inositol 5-phosphatase, phosphatidylinositol 4,5-bisphosphate has a tumour suppressive melanoma. Although it commonly downregulated melanoma, overexpression 5-phosphatase blocks Akt activation, inhibits proliferation and undermines survival melanoma cells vitro, retards growth xenograft...
The rhl quorum-sensing (QS) system plays critical roles in the pathogenesis of P. aeruginosa. However, regulatory effects that occur directly upstream QS are poorly understood. Here, we show deletion gene encoding for two-component sensor BfmS leads to activation its cognate response regulator BfmR, which turn binds promoter and decreases expression rhlR encodes RhlR, causing inhibition system. In absence bfmS, Acka-Pta pathway can modulate activity BfmR. addition, tunes 202 genes comprise...
Extracellular bacteria, such as Pseudomonas aeruginosa and Klebsiella pneumoniae, have been reported to induce autophagy; however, the role machinery of infection-induced autophagy remain elusive. We show that pleiotropic Src kinase Lyn mediates phagocytosis autophagosome maturation in alveolar macrophages (AM), which facilitates eventual bacterial eradication. report is required for recruitment autophagic components pathogen-containing phagosomes. When we blocked with 3-methyladenine (3-MA)...
The practical application of Lithium–Sulfur batteries largely depends on highly efficient utilization and conversion sulfur under the realistic condition high‐sulfur content low electrolyte/sulfur ratio. Rational design heterostructure electrocatalysts with abundant active sites strong interfacial electronic interactions is a promising but still challenging strategy for preventing shuttling polysulfides in lithium–sulfur batteries. Herein, ultrathin nonlayered NiO/Ni 3 S 2 nanosheets are...
Abstract Background Prohibitin 2 (PHB2) exhibits opposite functions of promoting or inhibiting tumour across various cancer types. In this study, we aim to investigate its and underlying mechanisms in the context gastric (GC). Methods PHB2 protein expression levels GC normal tissues were examined using western blot immunohistochemistry. level associations with patient outcomes through Kaplan–Meier plotter analysis utilizing GEO datasets (GSE14210 GSE29272). The biological role subsequent...
Bladder cancer (BLCA) is the most common genitourinary malignancy. Proliferation essential genes (PEGs) are crucial to survival of cells. This study aimed build a PEG signature predict BLCA prognosis and treatment efficacy.
The BMP/Smad signaling pathway plays an important role in the viability and differentiation of osteoblast; however, it is not clear whether this involved fluoride-induced osteoblast differentiation. In study, we investigated osteoblast-like Saos-2 cells Cells were exposed to fluoride different concentrations (0, 0.1, 0.2, 0.4, 0.8, 1.6 mM), cell proliferation was determined using WST assays. expression marker genes such as osteocalcin (BGP) bone alkaline phosphatase (BALP) detected by...
Objective Amyopathic dermatomyositis (ADM) is a heterogeneous and life‐threatening autoimmune disease with high mortality rate. In particular, anti–melanoma differentiation–associated protein 5 antibody–positive patients are at risk of developing rapidly progressive interstitial lung (RPILD). This study was undertaken to identify immunologic signatures among who have ADM ILD (ADM‐ILD) discover the biomarkers predicting prognosis. Methods The landscape 42 immune cell phenotypes in peripheral...
Klebsiella pneumoniae (Kp) is one of the most common pathogens in nosocomial infections and becoming increasingly multidrug resistant. However, underlying molecular pathogenesis this bacterium remains elusive, limiting therapeutic options. Understanding mechanism its may facilitate development anti‐bacterial therapeutics. Here, we show that Lyn, a pleiotropic Src tyrosine kinase, involved host defense against Kp by regulating phagocytosis process simultaneously downregulating inflammatory...