A5100651593- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Medical Imaging and Analysis
- Prostate Cancer Treatment and Research
- Salivary Gland Disorders and Functions
- Medical Image Segmentation Techniques
- Oral health in cancer treatment
- Effects of Radiation Exposure
- Advances in Oncology and Radiotherapy
- Radiation Effects in Electronics
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Atomic and Subatomic Physics Research
University of Pennsylvania
2017-2025
Ruijin Hospital
2021-2025
Shenzhen University Health Science Center
2024-2025
Shandong Jianzhu University
2025
Hangzhou Dianzi University
2025
Shanghai Jiao Tong University
2023-2025
St George Hospital
2024
Wenzhou Medical University
2007-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2024
Zhongda Hospital Southeast University
2023-2024
A greyscale-based fully automatic deformable image registration algorithm, originally known as the 'demons' was implemented for CT image-guided radiotherapy. We accelerated algorithm by introducing an 'active force' along with adaptive force strength adjustment during iterative process. These improvements led to a 40% speed improvement over original and high tolerance of large organ deformations. used three methods evaluate accuracy algorithm. First, we created set mathematical...
PurposeRecent studies suggest that ultrahigh-dose-rate, "FLASH," electron radiation therapy (RT) decreases normal tissue damage while maintaining tumor response compared with conventional dose rate RT. Here, we describe a novel RT apparatus delivers FLASH proton (PRT) using double scattered protons computed tomography guidance and provide the first report of RT-mediated radioprotection.Methods MaterialsAbsolute was measured at multiple depths in solid water validated against an absolute...
The purpose of this study was to analyze factors affecting proton stopping-power-ratio (SPR) estimations and range uncertainties in therapy planning using the standard stoichiometric calibration. SPR were grouped into five categories according their origins then estimated based on previously published reports or measurements. For first time, impact tissue composition variations estimation assessed uncertainty estimates each category determined for low-density (lung), soft, high-density...
Purpose: Commercial CT‐based image‐guided radiotherapy (IGRT) systems allow widespread management of geometric variations in patient setup and internal organ motion. This document provides consensus recommendations for quality assurance protocols that ensure safety treatment fidelity such systems. Methods: The AAPM TG‐179 reviews clinical implementation aspects commercially available IGRT, each with their unique capabilities underlying physics. described are kilovolt megavolt cone‐beam CT,...
The biological effectiveness of proton beams relative to photon in radiation therapy has been taken be 1.1 throughout the history therapy. While potentially appropriate as an average value, actual (RBE) values may differ. This Task Group report outlines basic concepts RBE well biophysical interpretation and mathematical concepts. current knowledge on variations is reviewed discussed context clinical use relevance (with respect physical parameters). following task group aims were designed...
Abstract In studies of electron and proton radiotherapy, ultrahigh dose rates FLASH radiotherapy appear to produce fewer toxicities than standard while maintaining local tumor control. FLASH-proton (F-PRT) brings the spatial advantages PRT (>40 Gy/second), making it important understand if how F-PRT spares normal tissues providing antitumor efficacy that is equivalent standard-proton (S-PRT). Here we studied damage skin mesenchymal muscle bone found C57BL/6 murine hind leg produced...
We discovered an empirical relationship between the logarithm of mean excitation energy (ln Im) and effective atomic number (EAN) human tissues, which allows for computing patient-specific proton stopping power ratios (SPRs) using dual-energy CT (DECT) imaging. The accuracy DECT method was evaluated 'standard' tissues as well their variance. compared to existing standard clinical practice—a procedure introduced by Schneider et al at Paul Scherrer Institute (the stoichiometric calibration...