A5101610756- Ionosphere and magnetosphere dynamics
- Geophysics and Gravity Measurements
- Methane Hydrates and Related Phenomena
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Amyotrophic Lateral Sclerosis Research
- Esophageal Cancer Research and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Facial Trauma and Fracture Management
- Head and Neck Surgical Oncology
- Breast Implant and Reconstruction
- Surgical site infection prevention
- Gastric Cancer Management and Outcomes
- Pleural and Pulmonary Diseases
- Diabetic Foot Ulcer Assessment and Management
- Autoimmune Bullous Skin Diseases
- Reproductive Biology and Fertility
- Peripheral Neuropathies and Disorders
Simon Fraser University
2025
New York University
2015-2024
Winthrop-University Hospital
2024
Unity Health Toronto
2024
St. Michael's Hospital
2021-2024
Island Hospital
2021-2023
Icahn School of Medicine at Mount Sinai
2021-2023
University of California, Berkeley
2023
Medical University of South Carolina
2023
Center for Innovation
2023
Gaucher disease (GD), the most common lysosomal storage disease, is caused by mutations in GBA1 encoding of β-glucocerebrosidase (GCase). Recently it was reported that progranulin (PGRN) insufficiency and deficiency associated with GD human mice, respectively. However underlying mechanisms remain unknown. Here we report PGRN binds directly to GCase its results aggregation receptor LIMP2. Mass spectrometry approaches identified HSP70 as a GCase/LIMP2 complex-associated protein upon stress, an...
Gaucher disease (GD) is a genetic caused by mutations in the GBA1 gene which result reduced enzymatic activity of β-glucocerebrosidase (GCase). This study identified progranulin (PGRN) (GRN) as another associated with GD.Serum levels PGRN were measured from 115 GD patients and 99 healthy controls, whole GRN 40 was sequenced, genotyping 4 SNPs performed 161 142 control samples. Development PGRN-deficient mice characterized, therapeutic effect rPGRN on analyzed.Serum significantly lower...
Abstract Background: This exploratory analysis evaluated second-line (2L) therapy for metastatic pancreatic cancer in a large phase 3 trial (MPACT). Methods: Patients who received first-line (1L) nab -paclitaxel+gemcitabine ( -P+Gem) or Gem were assessed survival based on 2L treatment received. Multivariate analyses tested influence of effect and prognostic factors survival. Results: The majority treatments (267 out 347, 77%) contained fluoropyrimidine (5-fluorouracil capecitabine). Median...
Dose modifications following adverse events (AEs) are an important part of the management patients with pancreatic cancer treated chemotherapy. While dose utilized to ensure patient safety, subsequent influence adjustments on treatment exposure and efficacy have not been reported in detail. This exploratory analysis examined phase III MPACT trial, which demonstrated superior nab-paclitaxel (nab-P) plus gemcitabine (Gem) Gem alone for metastatic cancer.Patients received either nab-P 125...
In a phase III trial in patients with metastatic pancreatic cancer (MPC), nab-paclitaxel plus gemcitabine (nab-P/Gem) demonstrated greater efficacy but higher rates of peripheral neuropathy (PN) versus Gem. This exploratory analysis aimed to characterise the frequency, duration, and severity PN nab-P/Gem MPACT study.Patients previously untreated MPC received or was evaluated using broad-spectrum group Standardised Medical Dictionary for Regulatory Activities Queries (SMQ) graded by National...
Gradient algorithms are the most commonly employed search methods in routine optimization of IMRT plans. It is well known that local minima can exist for dose-volume-based and biology-based objective functions. The purpose this paper to compare relative speed different gradient algorithms, investigate strategies accelerating process, assess validity these strategies, study convergence properties dose-volume biological With aims mind, we implemented Newton's, conjugate (CG), steepest decent...
Journal Article Microsurgical fertilization and teratozoospermia Get access Jacques Cohen, Cohen 1 Center for Reproductive Medicine Infertility, Department of Obstetrics Gynecology, New York Hospital-Cornell University Medical CenterNew York, NY 10021, USA 1To whom correspondence should be addressed Search other works by this author on: Oxford Academic PubMed Google Scholar Beth E. Talansky, Talansky Henry Malter, Malter Mina Alikani, Alikani Alexis Adler, Adler Adrienne Reing, Reing Alan...
ABSTRACT Adolescent mental health problems have increased internationally, and over one‐quarter of Chinese adolescents—approximately 40 million teens—have reported significant in recent years. This study tailored evaluated the acceptance, uptake, effectiveness Connect , a brief manualized trauma‐informed attachment‐based parenting program, for Mandarin‐speaking families Beijing, China. 30 parents (aged 36–50 years, M age = 44.6, SD 3.2; 83.3% mothers, 16.7% fathers) youth aged 10–16 years (...
AIM:To evaluate the dosimetry, efficacy and toxicity of intensity-modulated radiation therapy (IMRT) concurrent chemotherapy for patients with locally advanced cervical upper thoracic esophageal cancer. METHODS:A retrospective study was performed on 7 who were definitively treated IMRT chemotherapy.Patients did not receive included in this analysis.IMRT plans evaluated to assess tumor coverage normal tissue avoidance.Treatment response toxicities assessed. RESULTS:Five-to nine-beam used...
Results from the phase 3 Metastatic Pancreatic Adenocarcinoma Clinical Trial (MPACT) led to approval of nab-paclitaxel plus gemcitabine for first-line treatment metastatic pancreatic cancer. The current analysis evaluated effects versus on primary and lesions.In this previously described MPACT trial, changes in tumor burden were assessed using independently measured diameters lesions computed tomography or magnetic resonance imaging scans. Changes sums longest summarized descriptive...