A5057056915- Gut microbiota and health
- Infant Nutrition and Health
- Inflammatory Bowel Disease
- Parathyroid Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Urinary Bladder and Prostate Research
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Gastrointestinal motility and disorders
- Advanced Drug Delivery Systems
- Bipolar Disorder and Treatment
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Healthcare and Venom Research
- Immune Response and Inflammation
- Immunotoxicology and immune responses
- Air Quality and Health Impacts
- Vitamin D Research Studies
- Macrophage Migration Inhibitory Factor
- Cancer Mechanisms and Therapy
- Medicinal Plant Pharmacodynamics Research
- Polysaccharides Composition and Applications
- Phytochemistry and biological activity of medicinal plants
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Cell Function and Interaction
Chengdu University of Traditional Chinese Medicine
2018-2025
Abstract Background The complex etiology and pathogenesis underlying Chronic Non-Bacterial Prostatitis (CNP), coupled with the existence of a Blood Prostate Barrier (BPB), contribute to lack specificity poor penetration most drugs. Emodin (EMO), potential natural compound for CNP treatment, exhibits commendable anti-inflammatory, anti-oxidant, anti-fibrosis properties but suffers from same problems as other Methods By exploiting recognition lactoferrin (LF) receptors that target intestinal...
Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH severely limited by its low water solubility, bioavailability, poor colonic targeting. Although some nanoparticles have been developed oral delivery RH, most them mainly highlighted only one...
Ulcerative colitis (UC) faces some barriers in oral therapy, such as how to safely deliver drugs the colon and accumulate lesions. Hence, we report an advanced yeast particles system loaded with supramolecular nanoparticles ROS scavenger (curcumin) treat UC by reducing oxidative stress state inflammatory response accelerating reprogramming of macrophages. In this study, dual-sensitive materials are bonded on β-cyclodextrin (β-CD), D-mannose (Man) is modified adamantane (ADA), then curcumin...
Introduction Chronic kidney disease (CKD) is a chronic progressive characterized by abnormalities in structure or function caused variousfactors. It has become significant public health problem, posing threat to human worldwide. Shenshuaikang enema (SSKE) demonstrated notable efficacy and safety treating CKD, although its mechanism of action remains unclear. Methods The CKD rat model was induced using 2.5% adenine, the effect SSKE evaluated detecting uremic toxins, inflammatory cytokines,...
Abstract Ulcerative colitis (UC) is a chronic disease. A significant challenge for the management of UC to achieve delivery drugs multi‐layer colonic barriers, as existing are difficult penetrate these depths. In this study, novel drug system using yeast cell wall microparticles (YPs) developed co‐encapsulate Bacillus subtilis (BS) and Rhein (Rh) termed Rh‐YBS. This specifically targets microfold cells, enabling direct BS submucosa. Additionally, Rh enhances colonization in submucosa through...
Malignant tumors are complex systemic chronic diseases and one of the major causes human mortality. Targeted therapy, chemotherapy, immunotherapy, radiotherapy examples mainstream allopathic medicine treatments that effective for intermediate advanced malignant tumors. The ongoing use conventional has resulted in adverse responses drug resistance, which have hampered its efficacy. As an important component complementary alternative medicine, Chinese been found to antitumor effects played...
Acute kidney injury is a global problem, which brings great burden to the society and family. The component of rhubarb, Salvia miltiorrhiza, Astragalus membranaceus, safflower (CRSAS) has been proved as an useful agent treat acute (AKI) patients in China.To assess effect CRSAS on human renal tubular epithelial cells (HK-2) after hypoxia/reoxygenation (H/R) investigate potential mechanisms.Network pharmacology was used predict pathways shared by AKI. Cell counting kit-8 (CCK-8) HK-2 vitality....
Background Chronic kidney disease (CKD) is a prevalent chronic condition that poses significant threat to human health. There close connection between the gut and kidneys, jointly influencing onset progression of CKD through “gut-kidney axis.” Traditional Chinese medicine has shown potential in treatment, but specific mechanisms require further investigation. Objectives This study aims explore protective effects Mizhuo Enema (MZGCY) on function rats by regulating TLR4/MyD88/NF-κB signaling...