A5007963632- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Natural Compounds in Disease Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Computational Drug Discovery Methods
- Morinda citrifolia extract uses
- Nanoparticles: synthesis and applications
- Pancreatitis Pathology and Treatment
- Natural product bioactivities and synthesis
- Wound Healing and Treatments
- Rheumatoid Arthritis Research and Therapies
- Natural Antidiabetic Agents Studies
- Phytochemistry and Bioactive Compounds
- Autoimmune and Inflammatory Disorders Research
- Chromatography in Natural Products
- Bone health and treatments
- Medicinal Plants and Bioactive Compounds
- Electrospun Nanofibers in Biomedical Applications
- Biochemical Analysis and Sensing Techniques
- Probiotics and Fermented Foods
- Traditional Chinese Medicine Analysis
- Bone and Joint Diseases
- Ginseng Biological Effects and Applications
- Plant-based Medicinal Research
- Medicinal Plants and Neuroprotection
Chengdu University of Traditional Chinese Medicine
2021-2025
Sichuan Cancer Hospital
2021-2024
Sichuan Provincial Hospital of Traditional Chinese Medicine
2019-2023
This study aimed to analyze the therapeutic effect of Rhein on ulcerative colitis (UC) in mice and its possible mechanism. LPS-induced UC cell model DSS-induced mouse were used antiinflammatory vitro vivo, respectively. Network pharmacology analysis was conducted identify potential signaling pathways involved treating UC, results further confirmed through western blotting assay. 16sRNA sequencing performed regulatory gut microbiota mice. As indicated by results, could significantly inhibit...
Celastrol (CLT)-loaded PEG–PLGA nanoparticles (NPs/CLT) coated with neutrophil membranes (NNPs/CLT) were explored for the management of acute pancreatitis (AP). sized around 150 nm proven to selectively accumulate in pancreas rats AP. NNPs found overcome blood–pancreas barrier and specifically distributed pancreatic tissues. Moreover, showed more selective accumulation than without any membrane coating AP rats. Compared CLT solution NPs/CLT group, NNPs/CLT significantly downregulated levels...
The polarization of macrophages plays a critical role in the physiological and pathological progression rheumatoid arthritis (RA). Activated M1 overexpress folate receptors arthritic joints. Hence, we developed folic acid (FA)-modified liposomes (FA-Lips) to encapsulate triptolide (TP) (FA-Lips/TP) for targeted therapy RA. FA-Lips exhibited significantly higher internalization efficiency lipopolysaccharide (LPS)-stimulated RAW 264.7 cells than (Lips) absence folate. Next, an adjuvant-induced...
Abstract Ulcerative colitis (UC) is a chronic disease. A significant challenge for the management of UC to achieve delivery drugs multi‐layer colonic barriers, as existing are difficult penetrate these depths. In this study, novel drug system using yeast cell wall microparticles (YPs) developed co‐encapsulate Bacillus subtilis (BS) and Rhein (Rh) termed Rh‐YBS. This specifically targets microfold cells, enabling direct BS submucosa. Additionally, Rh enhances colonization in submucosa through...
Objective. Pain is a common symptom among patients, and pain management an important clinical practice topic. The mechanism of Huajiao (HJ; Zanthoxylum bungeanum Maxim.) its effective components for treating was explored using network pharmacology molecular docking to verify relief function in traditional medical practice. Methods. HJ’s were collected via the Traditional Chinese Medicine Systems Pharmacology platform published studies. HJ-associated target proteins predicted drug similarity...
Postmenopausal osteoporosis (PMOP) is a common age-associated disease in the life course. Clinically, Xiaozeng Qianggu Tablets (XQT) have potent therapeutic effect on PMOP. However, bioactive components and mechanism of XQT underlying PMOP treatment were unclear it should be explored to discover scientific connotation traditional medical practice.The identified by UPLC-Q-TOF/MS. The animal model was established surgical ovariectomy female Sprague-Dawley rats. After XQT, assessed...
This study aims to explore the core connotation of compatibility Aconiti Lateralis Radix Praeparata(Fuzi)-Glycyrrhizae et Rhizoma(Gancao) herb pair under physiological and pathological conditions. The biochemical indicators serum/myocardial tissue, changes myocardial serum metabolic profiles normal rats heart failure model treated with Fuzi Decoction Gancao were determined. Network pharmacology metabolomics employed establish metabolite-target-pathway network for Glycyrrhizae Rhizoma in...