A5100665308- Pancreatic function and diabetes
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Advanced Glycation End Products research
- Diet and metabolism studies
- Diverse Aspects of Tourism Research
- Environmental Quality and Pollution
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Apelin-related biomedical research
- Hereditary Neurological Disorders
- Advanced MRI Techniques and Applications
- Traditional Chinese Medicine Studies
- Lipid metabolism and disorders
- Chronic Kidney Disease and Diabetes
- Diet, Metabolism, and Disease
- Glaucoma and retinal disorders
- Regional Economic and Spatial Analysis
Gansu University of Traditional Chinese Medicine
2022-2025
Qinghai University
2025
Qinghai University Affiliated Hospital
2025
University of Electronic Science and Technology of China
2023-2024
Shanghai Sixth People's Hospital
2014-2024
Shanghai Jiao Tong University
2003-2024
Beihua University
2015-2024
Shandong Special Equipment Inspection Institute
2024
Inner Mongolia University of Finance and Economics
2006-2024
Shenzhen Maternity and Child Healthcare Hospital
2022
OBJECTIVE Oxidative stress is a major contributing factor in the development of diabetic nephropathy. Peroxisome proliferator–activated receptor γ heterozygous mice and Pro12Ala polymorphism PPARG exhibited increased resistance to oxidative stress. Smoking increases production reactive oxygen species, which accelerates under hyperglycemia. To determine whether polymorphism, alone or combination with smoking, contributes nephropathy, case-control study was performed 760 Chinese patients type...
Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the development of type 2 diabetes obesity. 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) mediates intracellular steroid exposure mouse liver GR by prereceptor reactivation is crucially dependent on hexose-6-phosphate (H6PDH)-generating NADPH system. Pharmacological inhibition 11β-HSD1 improves insulin intolerance Here, we evaluated potential beneficial effects inhibitor...
Long-term glucocorticoid exposure increases the risk for developing type 2 diabetes. Prereceptor activation of availability in target tissue by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) coupled with hexose-6-phosphate (H6PDH) is an important mediator metabolic syndrome. We explored whether tissue-specific modulation 11β-HSD1 and H6PDH adipose mediates glucocorticoid-induced insulin resistance lipolysis analyzed effects inhibition on key lipid metabolism genes insulin-signaling cascade....
Uncoupling protein-2 (UCP2) may regulate glucose-stimulated insulin secretion. The current study investigated the effects of berberine, an alkaloid found in many medicinal plants, on oxidative stress and secretion through restoration UCP2 expression high glucose (HG)-treated INS-1E cells rat islets or db/db mouse islets.Mouse pancreatic were isolated. Nitrotyrosine, superoxide dismutase (SOD)-1 AMPK phosphorylation examined by Western blotting. Insulin was measured ELISA. Mitochondrial...
Background and objectives: Renalase, a monoamine oxidase derived from the kidney, can degrade catecholamine (CA) regulate blood pressure as well cardiac function. To investigate changes of serum renalase levels in patients with Type 2 diabetes mellitus (DM) examine correlation other features T2DM. Methods: Seventy-five T2DM 13 healthy volunteers were studied. The CA measured by enzyme linked immunosorbent assay. Several biochemical clinical parameters measured. Results: Serum renalase/CA...
The high-quality development of culture and tourism is an important path for promoting the implementation rural revitalization strategy, urban-rural integration development, realizing common prosperity. This special issue focuses on major "rural tourism", contains 22 academic papers with in-depth discussions five themes: "Rural development", destination homestay "tourism environmental behavior farmers' participation in resilience risk", "cultural development". collection articles has three...
To observe the effect of heat-reinforcing needling on expression profile long non-coding RNA (LncRNA) in synovial tissue rabbits with cold-syndrome type rheumatoid arthritis (RA), so as to explore its mechanisms underlying improvement RA. A total 18 New Zealand were randomly divided into normal, model and (acupuncture) groups, 6 each group. The RA was established by injection mixed solution (emulsifier) ovalbumin powder(80 mg) + NaCl (20 mL) +Freund's complete adjuvant mL), combined cold...
Both blood urea nitrogen (BUN) and creatinine (Cr) are indicators of kidney function, the BUN/Cr ratio has been identified as an independent prognostic marker for adverse outcomes in critically ill patients with various conditions. However, relationship between long-term mortality acute pancreatitis (AP) remains unclear. Hence, primary objective this study was to determine value AP. We conducted a retrospective cohort using data from Medical Information Mart Intensive Care IV (MIMIC-IV)...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by dense and heterogeneous tumor microenvironment (TME) composed of various cancer-associated fibroblasts (CAFs). In this study, we explored the composition proportions CAF subtypes within PDAC TME identified three distinct CAF-related subtypes: iCAF-rich, myCAF-rich, PSC-rich. We observed significant heterogeneity in populations across different patients, which correlated with patient prognosis...
Abstract Hypertension is a systemic disorder that affects numerous physiological processes throughout the body. Improper sodium transport common comorbidity of hypertension, and also critical for maintaining secretion submandibular glands, whether function glands affected by hypertension remains unclear. To determine induces changes in protein expression we compared proteome from 14-week-old spontaneously hypertensive rats (SHR) Wistar Kyoto (WKY) using LC-MS/MS. The results revealed 95...
Abstract Renalase, a recently discovered secreted flavoprotein, exerts anti-apoptotic and anti-inflammatory effects against renal injury in acute chronic animal models. However, whether Renalase elicits similar the development of diabetic nephropathy (DN) remains unclear. The studies presented here tested hypothesis that may play key role DN have therapeutic potential for DN. expression was measured human kidney biopsies with kidneys db/db mice. examined using genetically engineered mouse...
Abstract Aims/Introduction To evaluate serum 25‐hydroxyvitamin D 3 (25( OH )D ) in newly diagnosed type 2 diabetes patients and to explore the associations of 25( with insulin resistance β‐cell function. Materials Methods A total 97 69 healthy controls were recruited. Serum was determined using high‐pressure liquid chromatography. Insulin measured a homeostasis model assessment ( HOMA ‐ IR ). β‐Cell function index ‐β), early‐phase secretion (ΔI30/ΔG30) area under curve AUC ins). Correlation...
Purpose: Diabetic nephropathy (DN), a major complication of diabetes mellitus, significantly impacts global health. Identifying individuals at risk developing DN is crucial for early intervention and improving patient outcomes. This study aims to develop validate machine learning-based predictive model using integrated biomarkers. Methods: A cross-sectional analysis was conducted on baseline dataset involving 2184 participants without DN, categorized based their development over follow-up...
To investigate the effect of idiopathic epiretinal membrane (ERM) on retinal-image quality and psychophysical contrast sensitivity function (CSF).Forty-four subjects with diagnosis unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffected eyes set as control group. For assessment, an Optical Quality Analysis System (OQAS) based double-pass technique was used to evaluate objective scatter index (OSI) Strehl ratio. visual performance, CSF under...