A5067810243- Rheumatoid Arthritis Research and Therapies
- Hormonal Regulation and Hypertension
- Gastric Cancer Management and Outcomes
- Spinal Cord Injury Research
- Liver Disease and Transplantation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Gastrointestinal disorders and treatments
- Pharmaceutical studies and practices
- Multicomponent Synthesis of Heterocycles
- Hippo pathway signaling and YAP/TAZ
- Genomic variations and chromosomal abnormalities
- Phytochemical and Pharmacological Studies
- Wnt/β-catenin signaling in development and cancer
- Autoimmune and Inflammatory Disorders Research
- Soft tissue tumor case studies
- ATP Synthase and ATPases Research
- Gallbladder and Bile Duct Disorders
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Chemotherapy-induced organ toxicity mitigation
- Ion Transport and Channel Regulation
- Biosimilars and Bioanalytical Methods
- Ginkgo biloba and Cashew Applications
- Receptor Mechanisms and Signaling
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
First Affiliated Hospital of Jiangxi Medical College
2025
Xuzhou Medical College
2024
Hebei Medical University
2014-2022
Second Hospital of Hebei Medical University
2014-2022
Zhejiang University
2022
Chinese PLA General Hospital
2013
Huainan Mining Industry Group (China)
2012
Jilin University
2008-2010
Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the development of type 2 diabetes obesity. 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) mediates intracellular steroid exposure mouse liver GR by prereceptor reactivation is crucially dependent on hexose-6-phosphate (H6PDH)-generating NADPH system. Pharmacological inhibition 11β-HSD1 improves insulin intolerance Here, we evaluated potential beneficial effects inhibitor...
The presence of a neurogenic bladder is severe but common complication spinal cord injury (SCI). Multiple pathological factors, such as hypoxia, ischemia, and oxidative stress caused by SCI, promote M1 microglial polarization the release proinflammatory factors to amplify inflammation. An excessive inflammatory response stimulates generation reactive oxygen species (ROS) induces neuronal ferroptosis, thus leading dysfunction after SCI. Therefore, promoting recovery neural function regulating...
Dorsal root ganglia (DRGs) have an important role in the peripheral mechanism of sensation by primary afferent neurons, which are widely used to research processes cell death, axonal regeneration, signal transmission growth factors and pain. In present study, we investigated activation autophagy DRGs a rat model acute spinal cord injury at different time points. Expression microtubule-associated protein light chain 3, marker was increased after 8 h DRGs, peaked 3 days, then gradually...
Abstract Introduction: Glucocorticoids (GCs), especially low-dose GCs, are commonly prescribed for rheumatoid arthritis (RA), although the risk/benefit ratio is controversial. A randomized, double-blind clinical trial was performed to evaluate efficacy and safety of oral GCs combined with methotrexate (MTX) hydroxychloroquine (HCQ) in early RA (ERA). Methods: Eighty untreated ERA patients were randomized into (GCs + MTX HCQ) control (placebo groups, 1-year treatment. Therapeutic evaluation...
Autoantibodies against the second extracellular loop of β(1) -adrenergic receptor (β(1) -AA) not only contribute to increased susceptibility heart failure, but also play a causative role in myocardial remodeling through their catecholamine-like effects via binding with receptor. The current study was designed determine whether -AA isolated from sera failure patients could cause TNF-α secretion murine macrophage-like cell line RAW264.7. Blood samples were collected 40 who had suffered as well...
Platinum-induced ovarian impairment is a consequence of treatment for malignant tumors.We compared the protective effects Ginkgo flavonoids, amifostine, and leuprorelin on in rats.Fifty rats were randomly divided into A, B, C, D, E groups, which given saline, cisplatin, cisplatin plus leuprorelin, respectively.Ovarian weight was significantly greater groups C D with group B (83.5 ± 6.7 86.8 10 vs 56.8 5.4 mg).The total follicle numbers higher than (60.5 3.9, 63.8 5.1, 67.7 3.5 49.6 4.5),...
The present work is aimed at exploring the clinical efficacy and safety of methotrexate (MTX) leflunomide (LEF) combination therapy for rheumatoid arthritis. From June 2019 to 2021, a total 120 individuals with arthritis received diagnosis. Sixty patients each were randomly assigned control observation groups. group MTX LEF combo medication while only treatment. Clinical efficacy, complication incidence, alleviation inflammatory markers, joint pain, symptoms compared between 2 Posttreatment,...
Abstract Background To evaluate the efficacy and safety of HLX01, a rituximab biosimilar, as combination therapy with methotrexate in Chinese patients active rheumatoid arthritis who had inadequate responses to methotrexate. Methods In this double-blind, placebo-controlled phase 3 trial, biologic-naïve moderate-to-severe were randomized 2:1 receive 1000 mg HLX01 or placebo intravenously on days 1 15. On first day weeks 24 26, both groups received via intravenous infusion. The primary...
Castleman disease, also known as giant lymph node hyperplasia, was first reported in 1956. It is a rare benign proliferative pathological change of the nodes.The patient, 33-year-old woman, had epigastric distension for half year. Examinations were performed local hospital. Computed tomography scan showed round soft tissue nodules, about 5.45 cm diameter, hepatic-gastric space. Endoscopic ultrasound and endoscopic guided fine needle aspiration on patient. Rapid on-site evaluation,...
Gastric variceal bleeding is often more serious and can be fatal. Currently, international consensus recommendations for the treatment of gastric vary according to endoscopic classification. Few studies have investigated ligation versus obturation (GVO) varices.The study included 79 patients with cirrhosis-induced from esophageal fundal varices who were treated at Second Hospital Hebei Medical University between January 2016 December 2020 met inclusion criteria. Among them, 42 in intensive...
To determine the risk factors for emergency endoscopic variceal ligation (EVL) failure in acute bleeding (AVB).Data from 161 cirrhosis patients with oesophageal who underwent EVL treatment at Second Hospital of Hebei Medical University January 2018 to May 2021 were retrospectively analysed. Enrolled divided into a successful group and failed group. The variables studied demographic, clinical, imaging, laboratory, data enrolled patients.Of patients, 19 experienced failure. Of these nine...
患者女，3d。“生后1 d因牙龈肿物”入院，行肿块切除术。镜下观察：病变表面被覆薄层鳞状上皮，肿瘤细胞主要由巢、片状分布的大的多边形及圆形细胞组成，胞质丰富嗜酸颗粒状，细胞核小圆形，未见核分裂象。肿瘤细胞间见丰富的毛细血管，部分管腔扩张。免疫组织化学染色瘤细胞波形蛋白弥漫阳性表达，S-100蛋白阴性。病理诊断为先天性颗粒细胞牙龈瘤。.
This study aimed to explore the clinical value of endoscopic ultrasonography (EUS) in resection gastrointestinal stromal tumors (GISTs).A retrospective 92 patients who were confirmed have GISTs by after EUS examination was conducted. The preoperative features examination, ultrasound diagnosis, methods, surgical procedures, complications, and complete degree lesion recorded. And 16 diagnosed endoscopy operation included analyzed subsequent part investigation (gastroscopy image analysis, risk...