A5100763003- Angiogenesis and VEGF in Cancer
- Multiple Sclerosis Research Studies
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Microbial infections and disease research
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Heavy Metal Exposure and Toxicity
- Cell Adhesion Molecules Research
- Medical Research and Treatments
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Traditional Chinese Medicine Studies
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Trace Elements in Health
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
Shandong First Medical University
2019-2025
Shandong Provincial QianFoShan Hospital
2016-2025
Southern University of Science and Technology
2022-2025
Liaoning University
2017-2025
Songjiang District Central Hospital
2025
First Affiliated Hospital of Zhengzhou University
2021-2025
Nankai University
2025
Shandong University
2015-2024
Shanghai University of Traditional Chinese Medicine
2013-2024
Sun Yat-sen University
2013-2024
In recent years, RNA interference (RNAi) therapeutics, most notably with lipid nanoparticle-based delivery systems, have advanced into human clinical trials. The results from these early trials suggest that nanoparticles (LNPs), and the novel ionizable lipids comprise them, will be important materials in this emerging field of medicine. A persistent theme use for biomedical applications has been incorporation biodegradability as a means to improve biocompatibility and/or facilitate...
Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery therapeutically active siRNAs hepatocytes in vivo. This approach become transformative for the RNAi therapeutics as well other classes investigational oligonucleotide liver. For efficient functional intact drug into desired subcellular compartment, however, it is critical that nucleic acids are stabilized against...
To inhibit bacterial infection in situ and improve osseointegration are essentially important for long-term survival of an orthopedic implant, particular infection-associating revision surgery. Herein, we fabricate a functional molybdenum disulfide (MoS2)/polydopamine (PDA)-arginine-glycine-aspartic acid (RGD) coating on titanium (Ti) implant to address above concerns simultaneously. The not only improved the osteogenesis mesenchymal stem cells (MSCs), but also endowed Ti substrates with...
Endothelial subcellular structures, including caveolae, fenestrae and transendothelial channels, are crucial for regulating microvascular function. Plasmalemma vesicle-associated protein (PLVAP) is an endothelial cell-specific that forms the stomatal fenestral diaphragms of blood vessels regulates basal permeability, leukocyte migration angiogenesis. Loss PLVAP in mice leads to premature mortality due disrupted homeostasis. Evidence from previous studies suggested involved cancer, traumatic...
Sympathetic nerve hyperactivity is a primary reason for fatal ventricular arrhythmias (VAs) following myocardial infarction (MI). Pro-inflammatory cytokines produced in the paraventricular nucleus (PVN) post-MI are associated with sympathetic overexcitation; however, precise mechanism needs further investigation. Our aim was to explore of toll-like receptor 4 (TLR4) and its downstream molecular pathway mediating activity within PVN. A rat MI model developed via left anterior descending...
Tumor-associated macrophages (TAMs) are the most important components in tumor immunosuppressive microenvironment, promoting growth and metastasis. Although TAMs have become one of hot topics immunotherapy, challenges still remain to achieve TAM-targeted re-polarization therapy. In this work, porous hollow iron oxide nanoparticles (PHNPs) were synthesized for loading a P13K γ small molecule inhibitor (3-methyladenine, 3-MA) further modified by mannose target TAMs. The delivery system named...
Sustained activation of NLRP3 inflammasome and release neutrophil extracellular traps (NETs) impair wound healing diabetic foot ulcers (DFUs). Our previous study reported that milk fat globule epidermal growth factor VIII (MFG-E8) attenuates tissue damage in systemic lupus erythematosus. However, the functional effect MFG-E8 on "NLRP3 inflammasome-NETs" inflammatory loop diabetes is not completely elucidated. In this study, neutrophils from DFU patients are susceptible to undergo NETosis,...
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) caused by pathogenic immunoglobulin G antibodies to myelin is a rare demyelinating of the central nerve system (CNS). The clinical phenotypes MOGAD include acute disseminated encephalomyelitis, optic neuritis, and transverse myelitis. At present, mechanism underlying unknown. Herein, we report two cases accompanied Epstein-Barr virus (EBV) infection. Both presented inflammation response in cerebrospinal fluid (CSF),...
This study aims to analyze the screening results and epidemiological characteristics of prostate cancer (PCa) among elderly males in rural areas Songjiang, Shanghai City, through implementation a preliminary prostate-specific antigen (PSA) based on community-linkage model, explore an effective approach. A retrospective observational design was employed collect data from residents who underwent PSA at Songjiang Hospital affiliated Jiao Tong University School Medicine, collaboration with...
Tumor necrosis factor alpha (TNF-alpha) is well-characterized for its necrotic action against tumor cells; however, it has been increasingly associated with an apoptosis-inducing potential on target cells. While the signaling events and actual cytolytic mechanism(s) both TNF-alpha-induced apoptosis remain to be fully elucidated, we report here (i) ability of TNF-alpha induce in promonocytic U937 cells, (ii) discovery a cross-talk between interferon pathways, (iii) pivotal role...
Genetic evidence supports an early role for Notch signaling in the fate of podocytes during glomerular development. Decreased expression transcriptional targets developing after determination cell suggests that constitutive may oppose podocyte differentiation. This study determined effects on differentiation by ectopically expressing Notch's intracellular domain (NOTCH-IC), biologically active, product proteolytic cleavage receptor, transgenic mice. Histologic and molecular analyses revealed...
The anti-malarial agent dihydroartemisinin (DHA) has strong anti-angiogenic activity. This study aimed to investigate the molecular mechanism underlying this effect of DHA on angiogenesis. We found that shows a dose-dependent inhibition proliferation and migration in HUVECs. specifically down-regulates mRNA protein expression VEGFR2 endothelial cells. Treatment with increases IκB-α blocks nuclear translocation NF-κB p65. In addition, directly regulates promoter activity through p65 binding...