A5100366050- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Non-Destructive Testing Techniques
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- RNA Interference and Gene Delivery
- Ultrasonics and Acoustic Wave Propagation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- Geophysical Methods and Applications
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Pancreatic function and diabetes
- Gold and Silver Nanoparticles Synthesis and Applications
- Metabolism, Diabetes, and Cancer
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2025
Chongqing University
2018-2023
Bioengineering Center
2019-2020
Flinders University
2018
Tumor hypoxia is one of the major challenges for treatment tumors, as it may negatively affect efficacy various anticancer modalities. In this study, a tumor-targeted redox-responsive composite biocatalyst designed and fabricated, which combine tumor starvation therapy low-temperature photothermal oxygen-deprived tumors. The nanosystem was prepared by loading porous hollow Prussian Blue nanoparticles (PHPBNs) with glucose oxidase (GOx) then coating their surface hyaluronic acid (HA) via...
Ferroptosis is a recently discovered route of regulated cell death that offers the opportunities for treatment chemotherapy-resistant tumor indications, but its efficacy can be affected by glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1) antioxidant mechanisms, posing significant challenges clinical translation. In this study, we report Cu-tetra(4-carboxyphenyl)porphyrin chloride(Fe(III)) (Cu-TCPP(Fe)) metal organic framework (MOF)-based nanosystem efficient...
Abstract The checkpoint blockade‐based immunotherapy has recently emerged as a promising approach for tumor treatment, but its clinical implementation been impeded by poor penetration of the nanocarriers and activation antitumor immune response. To overcome obstacles, acidity‐responsive micellar nanocomplex co‐loaded with programmed death‐ligand 1 (PD‐L1)‐blockade siRNA mitochondrion‐targeting photosensitizer synergistic integration photodynamic therapy is reported in present study....
As an increased product of high-rate aerobic glycolysis in tumors, lactate could regulate the immunosuppressive tumor microenvironment (TME). A PEG-CDM surface modified, GSH-dependent responsive hollow mesoporous organosilica nanoplatform loaded with hydroxycamptothecin (HCPT) and siMCT-4 was administrated for synergistic chemo-immunotherapy. The cascaded responded to weak acid TME high level GSH cells. HCPT were continuously released from chemotherapy inhibiting intracellular efflux....
Tumor-associated macrophages (TAMs) are the most important components in tumor immunosuppressive microenvironment, promoting growth and metastasis. Although TAMs have become one of hot topics immunotherapy, challenges still remain to achieve TAM-targeted re-polarization therapy. In this work, porous hollow iron oxide nanoparticles (PHNPs) were synthesized for loading a P13K γ small molecule inhibitor (3-methyladenine, 3-MA) further modified by mannose target TAMs. The delivery system named...
Abstract Liver tumor is difficult to cure for its high degree of malignancy and rapid progression characteristics. Ferroptosis as a new model inducing cell death expected break the treatment bottleneck liver tumors. Here, strategy induce ferroptosis in HepG2 cells with acid‐degradable targeted nanosheets Cu‐Hemin‐PEG‐Lactose acid (Cu‐Hemin‐PEG‐LA) proposed. After highly ingested by cells, Cu‐Hemin‐PEG‐LA are degraded weak release Cu(II) hemin, which consuming intracellular glutathione (GSH)...
The immunogenic cell death (ICD) of tumor cells has aroused great interest in the field immunotherapy, mainly due to production plentiful tumor-associated antigens (TAAs) and damage-associated molecule patterns. However, doxorubicin (DOX)-induced tumor-specific T-cell-mediated immune response is usually very weak because antigen presentation deficiency immunosuppressive microenvironment (ITME). Herein, probiotic Bifidobacterium bifidum (Bi) was covalently modified with DOX-loaded CaP/SiO2...
Synergistic therapies, such as chemo-photodynamic therapy, have been growing fast because of their efficacy against cancers. Although metal-organic frameworks widely studied in the field drug delivery, (MOFs) with a two-dimensional (2D) structure integrated by photosensitizers are rarely reported. However, therapy still has limitations inhibitory effect from intracellular glutathione (GSH). In this work, simple bottom-up synthesis method was used to synthesize pH-responsive delivery system...
Abstract The poor osseointegration and postoperative bacterial infection are prominently responsible for the failure of titanium (Ti)‐based implant in clinic. To address above issues, methacryloyl modified graphene oxide (GOMA) as zinc ions (Zn 2+ ) reservoir release platform was fabricated on Ti substrates with cathode electrophoresis deposition (EPD). Afterward, phenylboronic acid (PBA) functionalization methacryloyl‐gelatin (GelMA‐PBA) reacting GOMA through situ free‐radical...
Paclitaxel (PTX) and chloroquine (CQ) loaded bovine serum albumin (BSA) nanoparticles can achieve efficient glioma therapy<italic>via</italic>autophagy inhibition.
A redox-responsive drug carrier with asialoglycoprotein receptor (ASGPR) targeting is fabricated for liver tumor therapy.
Abstract Tumor reprogram pathway of mitochondrial metabolism is an emerging approach for malignant tumor treatment, such as triple‐negative breast cancer. In this study, a tumor/mitochondria cascaded targeting, adenosine‐triphosphate (ATP) responsive nanocarrier zeolitic imidazolate framework‐90 (ZIF‐90) cancer combination therapy reported. Atovaquone (AVO) and hemin are loaded into ZIF‐90, then peptide iRGD with tumor‐targeting ability modified on the ZIF‐90 nanoplatform. Hemin can...
Abstract Inhibiting the function of P‐glycoprotein (P‐gp) transporter, which causes drug efflux through adenosine triphosphate (ATP)‐dependent manner, has become an effective strategy to conquer multidrug resistance (MDR) cancer cells. However, there remains challenges for co‐delivery, sequential release P‐gp modulator and chemotherapeutic agent. In this work, a novel type core–shell nanoparticle is reported. It can independently encapsulate high amount (about 683 µg mg −1 ) agent...
A biocompatible nanocomposite of mesoporous silica-coated gold nanorods is fabricated for synergistic tumor therapy.
Abstract For effectively detecting the quasi-static component (QSC) of an ultrasonic longitudinal wave, which is closely related to elastic nonlinearity material, we proposed a novel pulse-echo piezoelectric transducer consisting high-frequency wafer, frequency selective isolation layer, low-frequency and acoustic backing. The wafer generates primary wave (PLW) tone burst, while high- wafers receive pulse echo containing both PLW QSC, respectively. We analyze formation burst in specimen,...
Abstract Nonlinear Rayleigh waves are useful for material surface damage detection. Traditional non-destructive testing (NDT) techniques based on higher harmonics of inevitably interfered with by the nonlinearity measurement systems. To overcome this disadvantage, an approach one-way collinear mixing (MRWs) is proposed to evaluate properties. A wedge two different incidence angles excitations transverse and longitudinal designed generate MRWs. The MRWs can be generated whole material,...