A5028023257- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Metamaterials and Metasurfaces Applications
- Advanced Thermoelectric Materials and Devices
- Copper-based nanomaterials and applications
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Mesenchymal stem cell research
- Advanced Antenna and Metasurface Technologies
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Chalcogenide Semiconductor Thin Films
- Immune cells in cancer
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Microwave Engineering and Waveguides
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Green IT and Sustainability
- Laser Applications in Dentistry and Medicine
- Silk-based biomaterials and applications
Chongqing University
2019-2024
Bioengineering Center
2019-2020
Hong Kong University of Science and Technology
2015-2018
University of Hong Kong
2015-2018
As an increased product of high-rate aerobic glycolysis in tumors, lactate could regulate the immunosuppressive tumor microenvironment (TME). A PEG-CDM surface modified, GSH-dependent responsive hollow mesoporous organosilica nanoplatform loaded with hydroxycamptothecin (HCPT) and siMCT-4 was administrated for synergistic chemo-immunotherapy. The cascaded responded to weak acid TME high level GSH cells. HCPT were continuously released from chemotherapy inhibiting intracellular efflux....
Tumor-associated macrophages (TAMs) are the most important components in tumor immunosuppressive microenvironment, promoting growth and metastasis. Although TAMs have become one of hot topics immunotherapy, challenges still remain to achieve TAM-targeted re-polarization therapy. In this work, porous hollow iron oxide nanoparticles (PHNPs) were synthesized for loading a P13K γ small molecule inhibitor (3-methyladenine, 3-MA) further modified by mannose target TAMs. The delivery system named...
In this study, the regulatory role and mechanisms of tantalum (Ta) particles in bone tissue microenvironment are explored. Ta particle deposition occurs both clinical samples animal tissues following porous implantation. Unlike titanium (Ti) promoting M1 macrophage (Mϕ) polarization, regulating calcium signaling pathways M2 Mϕ polarization. Ta-induced enhances marrow-derived mesenchymal stem cells (BMSCs) proliferation, migration, osteogenic differentiation through exosomes (Exo) by...
Abstract The poor osseointegration and postoperative bacterial infection are prominently responsible for the failure of titanium (Ti)‐based implant in clinic. To address above issues, methacryloyl modified graphene oxide (GOMA) as zinc ions (Zn 2+ ) reservoir release platform was fabricated on Ti substrates with cathode electrophoresis deposition (EPD). Afterward, phenylboronic acid (PBA) functionalization methacryloyl‐gelatin (GelMA‐PBA) reacting GOMA through situ free‐radical...
Topological characteristics of energy bands, such as Dirac/Weyl nodes, have attracted substantial interest in condensed matter systems well classical wave systems. Among these the type-II Dirac point is a nodal degeneracy with tilted conical dispersion, leading to peculiar crossing dispersion constant plane. Such points recently been found electronic materials. The analogous topological feature photonic remains theoretical curiosity, experimental realization expected be challenging. Here, we...
A redox-responsive drug carrier with asialoglycoprotein receptor (ASGPR) targeting is fabricated for liver tumor therapy.
Angiogenesis at the fracture site plays crucial roles in endogenous osteogenesis process and is a prerequisite for efficient repair of implant fixed bone defects. To improve peri-implant vascularization titanium accelerating defect healing, we developed Co-doped Mg-Al layered hydroxide coating on surface using hydrothermal reaction then modified with gallic acid (Ti-LDH/GA). Gallic enabled sustained release Co
A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for tumor-targeted delivery genes small-molecule anticancer drugs.
Titanium-based materials have been long regarded as effective bone implants for clinical use, yet the corresponding osteointegration ability needs to be optimized. This challenge can overcome by fabricating titanium (Ti) with physiological functions. In this study, peptide LL-37-loaded silk fibroin nanoparticles (SFNPs) were immobilized on a surface facilitate regulating functions of mesenchymal stem cells (MSCs) and macrophages. According our results, cell viability, recruitment paracrine...
A one-step synthesis of magnetic nickel nanowires (NiNWs) with tunable characteristics is reported. The method simple and easy to be conducted, leading high compatibility scaling-up. It discovered that the size morphology NiNWs can adjusted by tuning reaction temperature, time length, as well surfactant concentration. found products have shown purity which remained after being stored for several months. remarkable enhanced saturation magnetization product was also observed, compared bulk...
Compared to static conditions, MSCs in a dynamic matrix possess higher paracrine function as result of collecting mechanical dose through cytoskeleton-YAP system.
This work provides a facile and novel design of multifunctional electronic skin with micropillars for monitoring human body movements, temperature changes, spatial resolution, highlighting its great potential in personalized medicine.
Abstract Humidity sensors, benefit from their superior humidity‐sensitive components, are able to respond the environment moisture changes. Based on this feature, humidity sensor plays an increasingly vital role in biological detection. To improve performance of a large number optimizations have been made several aspects, such as material synthesis and structural design. In study, novel is designed increase its specific surface area carry more conductive materials. A porous...
Electrical stimulation has been used clinically as an adjunct therapy to accelerate the healing of bone defects, and its mechanism requires further investigations. The complexity physiological microenvironment makes it challenging study effect electrical signal on cells alone. Therefore, artificial system mimicking cell in vitro was developed address this issue. In work, a novel constructed based polypyrrole nanowires (ppyNWs) with high aspect ratio. Synthesized ppyNWs formed conductive...
The aim of this work is to fabricate and investigate nickel nanowires (NiNWs) as a novel magnetorheological material determine how the aspect ratio these magnetic particles influences its properties. latest methods for synthesizing NiNWs nanospheres (NiNSs) are presented corresponding fluids (MRF) obtained. Materials were characterized so that properties could be compared NiNSs. As different size fabricated, their saturation magnetization values increased increased. Moreover, MRF containing...