A5100329049- Metallurgy and Material Forming
- Advanced materials and composites
- Microstructure and Mechanical Properties of Steels
- Metal and Thin Film Mechanics
- Metal Alloys Wear and Properties
- Titanium Alloys Microstructure and Properties
- Additive Manufacturing Materials and Processes
- Aluminum Alloys Composites Properties
- Hydrogen embrittlement and corrosion behaviors in metals
- Corrosion Behavior and Inhibition
- Microstructure and mechanical properties
- Intermetallics and Advanced Alloy Properties
- Metal Forming Simulation Techniques
- Additive Manufacturing and 3D Printing Technologies
- Metallurgical Processes and Thermodynamics
- High-Velocity Impact and Material Behavior
- High Temperature Alloys and Creep
- biodegradable polymer synthesis and properties
- Non-Destructive Testing Techniques
- Extraction and Separation Processes
- Advanced Cellulose Research Studies
- High Entropy Alloys Studies
- Metal Extraction and Bioleaching
- Mechanical Behavior of Composites
- Powder Metallurgy Techniques and Materials
Chongqing University
2012-2024
California Polytechnic State University
2016-2024
China University of Geosciences (Beijing)
2023
Hebei University of Science and Technology
2023
Tianjin Special Equipment Supervision and Inspection Technology Research Institute
2021-2023
Shanghai University of Engineering Science
2022-2023
Naval University of Engineering
2020-2023
Harbin Institute of Technology
2017-2023
Jiangsu University of Science and Technology
2023
Northwestern Polytechnical University
2023
Abstract cGAS-STING pathway is a key DNA-sensing machinery and emerges as promising target to overcome the immunoresistance of solid tumors. Here we describe bovine serum albumin (BSA)/ferritin-based nanoagonist incorporating manganese (II) ions β-lapachone, which cooperatively activates signaling in dendritic cells (DCs) elicit robust adaptive antitumor immunity. Mn 2+ -anchored mannose-modified BSAs β-lapachone-loaded ferritins are crosslinked afford bioresponsive protein nanoassemblies,...
Ferroptosis is a nonapoptotic iron-dependent cell death pathway with significant clinical potential, but its translation impeded by lack of tumor-specific ferroptosis regulators and aberrant tumor iron metabolism. Herein, we report combinational strategy based on clinically tested constituents to selectively induce in metabolically reprogrammed cells through cooperative GPX4-inhibition ferritinophagy-enabled Fe2+ reinforcement. Azido groups were first introduced using biocompatible...
Cancer stem cells (CSCs) with hyperactivated signal transducer and activator of transcription 3 (STAT3) are a major driver hepatocellular carcinoma (HCC). Herein, we report nanointegrative proteolysis-targeting chimera (PROTAC)-based STAT3 degradation strategy that enables efficient chemical reprogramming HCC-associated CSCs, which potently inhibits CSC growth while evoking anti-HCC immune responses. The PROTAC prodrug was synthesized by conjugating the binding domain (inS3) thioketal-caged...
Nanocatalytic tumor therapy is an emerging antitumor option that employs catalytically-active inorganic nanostructures to produce tumor-damaging reactive oxygen species. However, initiation of nanocatalytic reactions in the intracellular environment a challenge due reliance on acidic pH. By exploiting pH-selective multifaceted catalytic activities Prussian blue-based nanomaterials (PBNM) as well hyperglycolysis characteristics tumors, it demonstrated blocking monocarboxylate transporter 4...
In order to predict hot deformation behavior of superalloy nimonic 80A, a back-propagational artificial neural network (BP-ANN) and strain-dependent Arrhenius-type model were established based on the experimental data from isothermal compression tests Gleeble-3500 thermo-mechanical simulator at temperatures ranging 1050–1250 °C, strain rates 0.01–10.0 s−1. A comparison BP-ANN modified constitutive equation has been implemented in terms statistical parameters, involving mean value relative...
Recent insights collectively suggest the important roles of lysyl oxidase (LysOX) in pathological processes several acute and chronic neurological diseases, but molecular regulatory mechanisms remain elusive. Herein, we explore role LysOX seizure-induced ferroptotic cell death neurons. Mechanistically, promotes ferroptosis-associated lipid peroxidation neurons via activating extracellular regulated protein kinase (ERK)-dependent 5-lipoxygenase (Alox5) signaling. In addition, overexpression...
A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for tumor-targeted delivery genes small-molecule anticancer drugs.