A5011573172- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Drug-Induced Hepatotoxicity and Protection
- Plant-based Medicinal Research
- Liver Disease Diagnosis and Treatment
- Berberine and alkaloids research
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Tryptophan and brain disorders
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects and Toxicity Studies
- Chromatography in Natural Products
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Neurological Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
China Pharmaceutical University
2016-2025
State Key Laboratory of Natural Medicine
2016-2025
Central Hospital of Wuhan
2022-2025
Tsinghua University
2023-2025
Huazhong University of Science and Technology
2022-2025
Centro de Investigacion Principe Felipe
2024
University of Pecs
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Hainan Medical University
2024
Hainan General Hospital
2024
Berberine, one of the most commonly used natural products, exhibits a poor plasma concentration-effect relationship whose underlying mechanisms remain largely unclear. This study was designed to test hypothesis that extensive first-pass elimination and abundant tissue distribution berberine may be its specific pharmacokinetic properties. For that, four different dosing routes, intragastric, intraduodenal, intraportal, intravenous, were investigate gastric, intestinal, hepatic berberine....
Apigenin is a non-toxic natural flavonoid that abundantly present in common fruits and vegetables. It has been reported apigenin various beneficial health effects such as anti-inflammation chemoprevention. Multiple studies have shown inflammation an important risk factor for atherosclerosis, diabetes, sepsis, liver diseases, other metabolic diseases. Although it long realized anti-inflammatory activities, the underlying functional mechanisms are still not fully understood.In study, we...
Berberine is an important ingredient in a number of traditional Chinese medicines but has been shown to have poor bioavailability the dog. The aim this study was use P-glycoprotein (P-glycoprotein) inhibitors cyclosporin A, verapamil and monoclonal antibody C219 vivo vitro models intestinal absorption determine role berberine absorption. In rat recirculating perfusion model, improved 6-times by inhibitors. everted sac serosal-to-mucosal transport significantly decreased A. Ussing-type...
Obesity and type 2 diabetes are national worldwide epidemics. Because currently available antiobesity antidiabetic drugs have limited efficacy and/or safety concerns, identifying new medicinal agents, such as ginsenoside Rb1 (Rb1) reported here, offers exciting possibilities for future development of successful therapies.Changes in feeding behavior after acute intraperitoneal administration the effects 4 weeks on body weight, energy expenditure, glucose tolerance high-fat diet (HFD)-induced...
Previous studies suggest that the lipid-lowering effect of berberine (BBR) involves actions on low-density lipoprotein receptor and AMP-activated protein kinase signaling pathways. However, implication these mechanisms is unclear because low bioavailability BBR. Because main action site BBR gut intestinal farnesoid X (FXR) plays a pivotal role in regulation lipid metabolism, we hypothesized effects FXR pathway might account for its pharmacological effectiveness. Using wild type (WT)...
Cholangiocarcinoma (CCA) is an often fatal primary malignancy of the intra- and extrahepatic biliary tract that commonly associated with chronic cholestasis significantly elevated levels conjugated bile acids (CBAs), which are correlated duct obstruction (BDO). BDO has also recently been shown to promote CCA progression. However, whereas there increasing evidence linking abnormal acid profiles development progression, specific mechanisms by may be acting cholangiocarcinogenesis invasive...
Bile acids play a pivotal role in the pathological development of inflammatory bowel disease (IBD). However, mechanism bile acid dysregulation IBD remains unanswered. Here we show that intestinal peroxisome proliferator-activated receptor α (PPARα)-UDP-glucuronosyltransferases (UGTs) signalling is an important determinant homeostasis. Dextran sulphate sodium (DSS)-induced colitis leads to accumulation inflamed colon tissues via activation PPARα-UGTs pathway. UGTs accelerate metabolic...
Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH) and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse preclinical animal models, the response rate efficacies clinical trials were not optimum. Here we report that prophylactic but therapeutic administration of obeticholic acid (OCA) prevents hepatic stellate cell (HSC) activation fibrogenesis. Activated HSCs show limited to OCA other due enhanced SUMOylation....