A5049399600- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Natural product bioactivities and synthesis
- Birth, Development, and Health
- Viral Infections and Vectors
- Pregnancy and preeclampsia studies
- Animal Disease Management and Epidemiology
- Liver Diseases and Immunity
- Gestational Diabetes Research and Management
- Vector-Borne Animal Diseases
- Drug-Induced Hepatotoxicity and Protection
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- HER2/EGFR in Cancer Research
- Mosquito-borne diseases and control
- Phytochemistry and Biological Activities
- Nutrition and Health in Aging
- Tryptophan and brain disorders
- Body Composition Measurement Techniques
- Silymarin and Mushroom Poisoning
- Galectins and Cancer Biology
- Hemodynamic Monitoring and Therapy
- Connective Tissue Growth Factor Research
Air Force Medical University
2025
Northeastern University
2024
Hangzhou City University
2024
Guangzhou Medical University
2024
Beijing Academy of Agricultural and Forestry Sciences
2023
First Affiliated Hospital of Kunming Medical University
2023
Poultry Research Institute
2023
Kunming Medical University
2023
Guangzhou University of Chinese Medicine
2022-2023
China Pharmaceutical University
2017-2021
Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH) and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse preclinical animal models, the response rate efficacies clinical trials were not optimum. Here we report that prophylactic but therapeutic administration of obeticholic acid (OCA) prevents hepatic stellate cell (HSC) activation fibrogenesis. Activated HSCs show limited to OCA other due enhanced SUMOylation....
Obeticholic acid (OCA), the first FXR-targeting drug, has been claimed effective in therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be against fibrosis, possibly due to lower dosage reduce incidence side-effect pruritus. Here we propose a combinatory therapeutic strategy and apoptosis inhibitor for combating CCl
Capsaicin (CAP) is an active ingredient in chili pepper that frequently consumed. It exerts various pharmacological activities, and also has potential effects on mental illness. However, its mechanism of antidepressant still unclear. Based the emerging perspective gut-brain axis, we investigated dietary CAP gut microbes mice with depression-like behaviors induced by lipopolysaccharide (LPS). C57BL/6J male (four weeks old) were given specific feed (standard laboratory chow or plus 0.005% CAP)...
Seneca Valley virus (SVV) causes vesicular disease in pigs, posing a threat to global pork production. OPTN (optineurin) is macroautophagy/autophagy receptor that restricts microbial propagation by targeting specific viral or bacterial proteins for degradation. degraded and cleaved at glutamine 513 following SVV infection via the activity of 3C protease (3C[pro]), resulting N-terminal C-terminal fragments. Moreover, interacts with VP1 targets degradation inhibit replication. The sustained...
BackgroundHepatocyte is particularly vulnerable to apoptosis, a hallmark of many liver diseases. Although pro-apoptotic mechanisms have been extensively explored, less known about the hepatocyte-specific anti-apoptotic molecular events and it lacks effective approach combat hepatocyte apoptosis. We investigated effect mechanism farnesoid X receptor (FXR), strategies how target FXR for inhibiting apoptosis implicated in fibrosis.MethodsSensitivity was compared between wild type Fxr−/− mice...
Introduction As a systemic autoimmune disorder, the prognosis of rheumatoid arthritis (RA) is intricately linked to inflammation. This study aimed investigate association between advanced lung cancer inflammation index (ALI), comprehensive indicator combined with nutritional status, and all-cause cardiovascular mortality among patients diagnosed RA. Methods The 2,305 RA from NHANES (2001–2018) included in analysis were categorized into three groups according ALI tertiles. Weighted...
Acute and critical neurological diseases are often accompanied with elevated intracranial pressure (ICP), leading to insufficient cerebral perfusion, which may cause severe secondary lesion. Existing ICP monitoring techniques fail effectively meet the demand for real-time noninvasive warning. This study aimed explore use of electrical impedance tomography (EIT) provide early warning by observing perfusion. An hypertension model was prepared injecting autologous un-anticoagulated blood into...
Abstract Background Liquidambaris Fructus (LF) is the infructescence of Liquidambar formosana . In Traditional Chinese Medicine, LF has been used to treat joint pain, a common symptom arthritis and rheumatism; however, lack pharmacological evidence limited its applications in modern clinics. Therefore, this study aims explore protective effect on rheumatoid (RA) identify active ingredients. Methods Rats with adjuvant-induced (AIA) were divided into 4 groups administered petroleum ether...
Type I interferon (IFN) signaling plays a principal role in host innate immune responses against invading viruses. Viruses have evolved diverse mechanisms that target the Janus kinase-signal transducer and activator of transcription (STAT) pathway to modulate IFN response negatively. Seneca Valley virus (SVV), an emerging porcine picornavirus, has received great interest recently because it poses threat global pork industry. However, molecular mechanism by which SVV evades immunity remains...
Abstract In hyperglycemia-induced complications, macrophages play important roles in disease progression, and altered digestion is a key feature that dictates macrophage function. Recent evidence indicates kakonein (Ka) possesses anti-inflammatory activities for complication. this study, we established mouse model of Nlrp3+/+ Nlrp3−/− hyperglycemia administering Ka, primary culture were tested by engulfing digesting microbes. The role the cathepsin B–NLRP3 pathway involved mechanism Ka...
Preeclampsia (PE) is a typical hypertensive disorders of pregnancy (HDP) which can cause substantial morbidity and mortality in both pregnant women fetuses. The renin-angiotensin system (RAS) genes are the main HDP-causing genes, Angiotensinogen (AGT) as initial substrate directly reflect activity entire RAS. However, association between AGT SNPs PE risk has rarely been confirmed. This study was carried out to determine whether could affect 228 cases 358 controls. genotyping result revealed...
Severe sarcopenia may result in severe disability. Early diagnosis is currently the key to enhancing treatment of sarcopenia, and there an urgent need for a highly sensitive dependable tool evaluate course early clinical practice. This study aims investigate longitudinally diagnosability magnetic resonance imaging (MRI)-based fat infiltration blood flow perfusion technology progression.