A5085804895- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- interferon and immune responses
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Intracranial Aneurysms: Treatment and Complications
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Caveolin-1 and cellular processes
- Cellular Mechanics and Interactions
- Advanced Photonic Communication Systems
- Traumatic Brain Injury and Neurovascular Disturbances
- Connective tissue disorders research
- Glycosylation and Glycoproteins Research
Xijing Hospital
2015-2025
Capital Medical University
2017-2025
Beijing Friendship Hospital
2017-2025
Air Force Medical University
2015-2025
National Clinical Research Center for Digestive Diseases
2017-2025
Peking University
2024
Peking University International Hospital
2024
Tianjin Medical University General Hospital
2023
Shaanxi Normal University
2023
Beihua University
2022
Abstract Although temozolomide (TMZ) provides significant clinical benefit for glioblastoma (GBM), responses are limited by the emergence of acquired resistance. Here, we demonstrate that exosomal circCABIN1 secreted from TMZ-resistant cells was packaged into exosomes and then disseminated TMZ resistance receipt cells. CircCABIN1 could be cyclized eukaryotic translation initiation factor 4A3 (EIF4A3) is highly expressed in GBM tissues glioma stem (GSCs). required self-renewal maintenance...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common and aggressive malignancies in China. Cancer‐associated fibroblasts (CAFs) can actively communicate with stimulate tumor cells, thereby contributing to development progression tumors. Yet, whether CAFs‐derived exosomes have a role ESCC largely unknown. Here, we find that Sonic Hedgehog (SHH) highly expressed CAFs lysis solution, conditioned medium cultured (CAF‐CM) exosomes, esophageal cancer lines educated by...
Abstract Previous studies revealed that Asporin (ASPN) is a potential mediator in the development of various types cancer as secreted stroma protein, but function ASPN inside cells remains largely unknown. Here, we demonstrated higher expression level colorectal (CRC) than matched normal tissues, and 25% (2/8) CRC showed copy number variation (CNV) gain/amplification gene. Both levels CNV indicated worse prognosis patients. can promote proliferation, migration, invasion cells, inhibit...
Esophageal squamous cell cancer (ESCC) has a high mortality rate. MicroRNA (miR)‑92a‑3p is considered to be tumor promotor and an oncomiR. The aim of the present study was investigate effect miR‑92a‑3p its target gene on ESCC in terms proliferation, migration invasion. Higher expression detected tissues patients with ESCC, compared that normal tissues. In addition, lines had higher esophageal cells. A mimic found promote proliferation inhibitor reduce proliferation. transfection accelerated...
Abstract Purpose Cholecystectomy (XGB) is widely recognized as a risk factor for colon cancer (CC). Continuous exposure of the colonic epithelium to deoxycholic acid (DCA) post-XGB may exert cytotoxic effects and be involved in progression CC. However, functions XGB-induced DCA increase underlying mechanism remain unclear. Methods Colitis-associated CC (CAC) mouse models constructed by AOM-DSS inducement were used confirm effect XGB on progression. Hematoxylin & eosin staining was...
Abstract The tripartite motif (TRIM) 22 and mitogen-activated protein kinase (MAPK) signaling pathways play critical roles in the growth of glioblastoma (GBM). However, molecular mechanism underlying relationship between TRIM22 MAPK remains unclear. Here, we found that binds to exon 2 sphingosine ( SPHK2 ) gene. An ERK1/2-driven luciferase reporter construct identified as a potential activator signaling. Knockout overexpression regulate inhibition activation through RING-finger domain....
Early diagnosis of colorectal cancer (CRC) is clinically critical but technically challenging, especially in a minimal-invasive way. Emerging evidence suggests that exosome-encapsulated microRNAs (miRNAs) kind promising biomarker. Here we investigated the predictive potential exosomal miR-92b plasma samples obtained from 114 participants [40 CRC, 22 adenomas (CA), 52 non-neoplasm controls (NC)] by RT-qPCR. We found level was significantly down-regulated CRC patients compared with CA and NC...
Compelling evidence suggests that glioblastoma (GBM) recurrence results from the expansion of a subset tumor cells with robust intrinsic or therapy-induced radioresistance. However, mechanisms underlying GBM radioresistance and remain elusive. To overcome obstacles in research, we present novel preclinical model ideally suited for radiobiological studies. With this model, performed screen identified radiation-tolerant persister (RTP) subpopulation. RNA sequencing was on RTP parental to...
Colon cancer (CC) is one of the most common malignances in digestive tract.M2-polarized macrophages within tumor microenvironment could facilitate CC cell growth by transferring molecules via extracellular vesicles, but mechanisms are not fully elucidated.The current study aims to identify possible effectors M2 macrophage-derived vesicles (M2-EVs) and reveal related molecular mechanisms.In our study, we validated promotion effects M2-EVs on proliferation motility cells, which was found be...
MicroRNAs (miRNAs) are small noncoding RNAs, which regulate numerous cell functions by targeting mRNA for cleavage or translational repression, and have been found to play an important role in Alzheimer's disease (AD). Our study aimed identify differentially expressed miRNAs AD brain as a reference of potential therapeutic biomarkers this disease. We used amyloid precursor protein (APP) presenilin 1 (PS1) double transgenic mice age-matched wild-type (WT) littermates determine the expression...
Purpose: Glioblastoma is the most common and aggressive type of primary brain malignancy associated with a poor prognosis. Previously, we found that phosphatase regenerating liver-3 (PRL-3) was significantly up-regulated in glioblastoma as determined by microarray analysis. However, function PRL-3 remains unknown. We aimed to investigate clinical relationship between glioblastoma, uncover mechanisms process glioblastoma. Methods: expression evaluated 61 samples 4 cell lines RT-qPCR...
Asporin (ASPN), a member of small leucine-rich repeat proteoglycan (SLRP) family proteins, serves important roles in diverse biological responses and disease conditions. We tested the hypothesis that ASPN regulated proliferation gastric cancer (GC) cells identified its down-stream regulators. promoted GC cells. effector this effect as proteasome 26S subunit non-ATPase 2 (PSMD2) which is known to regulate through suppression DUSP7, WIP1 PTEN then inducing phosphorylation ERK, P38 AKT. PSMD2...
Matrix Gla protein (MGP), an extracellular matrix protein, is mainly associated with the inhibition of calcification in skeleton, coronary artery, and kidney, more recently it has also been implicated cancer. However, biological function MGP inside cancer cells its role colon (CC) remain largely unknown. expression association clinicopathologic characteristics CC were analyzed by immunohistochemistry verified Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) datasets. effects on...
Matrix Gla protein (MGP) has been widely reported as an extracellular matrix with abnormal expression in various types of cancer. However, the function intracellular MGP gastric cancer (GC) cells remains largely unknown. Here, we demonstrated aberrantly high GC compared to adjacent normal tissues by immunohistochemistry. Moreover, The Cancer Genome Atlas (TCGA) dataset analysis suggested a positive correlation between overexpression and unfavorable prognosis. silencing reduced cell...
Helicobacter pylori (H. pylori) infection is closely associated with the occurrence and development of gastric diseases. Therefore, eliminating H. should help to prevent Vitamin D3 (VitD3, 1,25(OH)2D3) was previously observed have anti-H. activity in clinic, but these results were reported heterogeneous vivo studies without elucidation underlying mechanisms. In present study, we established models both wild-type VDR knockdown (VDR-KD) mice, which used demonstrate that VitD3 inhibits by...
Glioblastoma (GBM) is the most malignant tumor of central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role treatment GBM. However, major impediments to effective are postoperative recurrence acquired resistance chemoradiotherapy. Our previous studies confirm that Yin Yang 1 (YY1) highly expressed GBM, whereby it associated with cell dedifferentiation, survival, therapeutic resistance. Targeted delivery small interfering RNA (siRNA) without...
Hinokitiol is a natural bioactive tropolone derivative isolated from Chamaecyparis obtusa and Thuja plicata, which exhibits promising potential in terms of antioxidant anti-inflammatory properties possesses potent iron-binding capacity. In this study, we aimed to investigate the role hinokitiol protecting against ethanol-induced gastric injury elucidate underlying mechanism. Our results demonstrated that effectively attenuated hemorrhagic lesions, epithelial cell loss, inflammatory response...