A5001704075- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Mechanisms of cancer metastasis
- Genetic Neurodegenerative Diseases
- Advanced Thermoelectric Materials and Devices
- Advanced machining processes and optimization
- Advanced Surface Polishing Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Heat Transfer and Optimization
- MicroRNA in disease regulation
- Advanced Measurement and Metrology Techniques
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Magnesium in Health and Disease
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Tunneling and Rock Mechanics
- HER2/EGFR in Cancer Research
- Eicosanoids and Hypertension Pharmacology
- Simulation and Modeling Applications
- Cancer Cells and Metastasis
- FOXO transcription factor regulation
- Respiratory Support and Mechanisms
Third Xiangya Hospital
2019-2025
Air Force Medical University
2012-2025
Central South University
2019-2025
Zhengzhou University
2012-2025
Hebei University of Architecture
2023-2025
Shandong University
2024
Tang Du Hospital
2013-2024
Jilin Electric Power Research Institute (China)
2024
Pfizer (China)
2022-2024
Changchun Institute of Optics, Fine Mechanics and Physics
2023
Cancer cells respond to various stressful conditions through the dynamic regulation of RNA m6A modification. Doxorubicin is a widely used chemotherapeutic drug that induces DNA damage. It interesting know whether cancer regulate damage response and doxorubicin sensitivity Here, we found treatment significantly induced methylation in breast both dose- time-dependent manner. However, protein arginine methyltransferase 5 (PRMT5) inhibited modification under by enhancing nuclear translocation...
Abstract Relying on the Beijing-Zhangjiakou high-speed railway Cao Mao Shan tunnel project, blasting vibration monitoring and sound wave testing experiments were carried out. The results show that velocity corresponding to initial support satisfies Sadowski formula. of sonic test with increase times, cumulative damage increases gradually, but increment shows a downward trend. In addition, as distance decreases, effect is significant. Through data analysis curve fitting, range R cr critical...
Abstract Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)‐positive breast cancer. However, many patients still develop resistance to tamoxifen in association with metastatic recurrence, which presents a tremendous clinical challenge. To better understand from perspective of tumor microenvironment, whole microenvironment landscape is charted by single‐cell RNA sequencing and new cancer‐associated fibroblast (CAF) subset, CD63 + CAFs, identified that promotes...
A common digestive system cancer with a dismal prognosis and high death rate globally is breast (BRCA). BRCA recurrence, metastasis, medication resistance are all significantly impacted by stem cells (CSCs). However, the relationship between CSCs tumor microenvironment in individuals remains unknown, this information critically needed. Our research utilized bioinformatics techniques TCGA data to explore complex development. We identified 26 cell gene sets from Stem Checker database...
Heart failure is a common complication of sepsis with high mortality rate. It has been reported that melatonin can attenuate septic injury due to various properties. On the basis previous reports, this study will further explore effects and mechanisms pretreatment, posttreatment, combination antibiotics in treatment myocardial injury.Our results showed pretreatment an obvious protective effect on injury, which was related attenuation inflammation oxidative stress, improvement mitochondrial...
Abstract Background NDRG 2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that expressed differentially normal and cancer tissues. Specifically, mRNA down-regulated or undetectable several human cancers, over-expression of inhibited the proliferation cells. also exerts important functions cell differentiation tumor suppression. However, it remains unclear whether participates carcinogenesis thyroid. Methods In this study, we...
HOXD10, a key regulator of cell-differentiated phenotype maintainence, has been demonstrated to be involved in the tumorigenesis many human malignacies. However, status HOXD10 expression and its biological function cholangiocellular carcinoma (CCC) remain clarified. In present study, we investigated clinical significance functions CCC found that downstream effector RHOC was significantly different well-differentiated tissues compared with poorly-differentiated lesions. We also observed...
Purpose: Glioblastoma is the most common and aggressive type of primary brain malignancy associated with a poor prognosis. Previously, we found that phosphatase regenerating liver-3 (PRL-3) was significantly up-regulated in glioblastoma as determined by microarray analysis. However, function PRL-3 remains unknown. We aimed to investigate clinical relationship between glioblastoma, uncover mechanisms process glioblastoma. Methods: expression evaluated 61 samples 4 cell lines RT-qPCR...
The purpose was to provide an overview of genotype and phenotype distribution in a cohort patients with Charcot-Marie-Tooth disease (CMT) related disorders from central south China.In all, 435 were enrolled detailed clinical data collected. Multiplex ligation-dependent probe amplification for PMP22 duplication/deletion CMT multi-gene panel sequencing performed. Whole exome further applied the remaining who failed achieve molecular diagnosis.Among patients, 216 had CMT1, 14 hereditary...
Abstract Aim SOX4, as a member of the SRY-related HMG-box (SOX) transcription factor family, has been demonstrated to be involved in tumorigenesis many human malignancies; however, its role primary gallbladder carcinoma (PGC) is still largely unknown. The aim this study was investigate SOX4 expression PGC and prognostic significance. Methods From 1997 2006, 136 patients underwent resection for PGC. median follow-up 12.8 months. Immunostainings were performed on these archival tissues....