A5102803121- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Identification and Quantification in Food
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Ichthyology and Marine Biology
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Aquaculture disease management and microbiota
- Immunotherapy and Immune Responses
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Myasthenia Gravis and Thymoma
- Liver Disease Diagnosis and Treatment
Tsinghua University
2022-2025
Zhejiang Ocean University
2018-2025
Beijing Tsinghua Chang Gung Hospital
2022-2025
Shanghai University of Traditional Chinese Medicine
2025
Guangzhou University of Chinese Medicine
2024-2025
Yueyang Hospital
2025
Air Force Medical University
2015-2024
Sun Yat-sen University
2021-2024
Sun Yat-sen University Cancer Center
2021-2024
China International Science and Technology Cooperation
2020-2024
Abstract In face of the everlasting battle toward COVID-19 and rapid evolution SARS-CoV-2, no specific effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme 2 (ACE2), a receptor mediates virus infection by binding to spike protein. Although ACE2 is expressed in lung, kidney, intestine, its expressing levels are rather low, especially lung. Considering great infectivity COVID-19, we speculate that SARS-CoV-2 may depend on other routes...
SUMMARY Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of disease, which poses great challenge to control and contain virus. Here, we reported a research finding that SARS-CoV-2 invaded host cells via novel route CD147-spike protein (SP). SP bound CD147, receptor on cells, thereby mediating viral invasion. Our further confirmed this...
Abstract The cell ecology and spatial niche implicated in the dynamic sequential process of lung adenocarcinoma (LUAD) from situ (AIS) to minimally invasive (MIA) subsequent (IAC) have not yet been elucidated. Here, we performed an integrative analysis single-cell RNA sequencing (scRNA-seq) transcriptomics (ST) characterize atlas invasion trajectory LUAD. We found that UBE2C + cancer subpopulation constantly increased during LUAD with remarkable elevation IAC, its distribution was peripheral...
The benefit of neoadjuvant camrelizumab plus chemotherapy for resectable stage IIIA or IIIB non-small cell lung cancer (NSCLC) remains unknown.To assess the efficacy and safety vs alone patients with NSCLC.In this randomized phase 2 clinical trial conducted at hospitals in China, aged 18 to 70 years (T3N2) NSCLC were enrolled between April 7, 2020, January 12, 2022.Patients randomly assigned receive 3 cycles (200 mg) (nab-paclitaxel, 130 mg/m2, platinum [cisplatin, 75 mg/m2; carboplatin,...
Exosomes are now considered to be involved in mediating cell-to-cell communication promote or inhibit tumor progression. However, the role and molecular mechanism of exosomes promoting glioblastoma (GBM) metastasis remains elusive. Here, we found that circulating exosomal miR-148a levels were significantly higher serum from GBM patients compared with healthy volunteers. In T98G cells, inhibition suppressed cell proliferation metastasis. addition, identified Cell adhesion molecule 1 (CADM1)...
Portal vein tumor thrombus (PVTT) is very common and it plays a major role in the prognosis clinical staging of hepatocellular carcinoma (HCC). We have published first version guideline 2016 revised 2018. Over past several years, many new evidences for treatment PVTT become available, especially advent targeted drugs immune checkpoint inhibitors which further improved PVTT. So, Chinese Association Liver Cancer Medical Doctor 2018 to adapt development treatment. Future strategies HCC with...
Abstract Background HER2-low could be found in some patients with triple-negative breast cancer (TNBC). However, its potential impacts on clinical features and tumor biological characteristics TNBC remain unclear. Methods We enrolled 251 consecutive retrospectively, including 157 (HER2 low ) 94 HER2-negtive neg to investigate the prognostic features. Then, we performed single-cell RNA sequencing (scRNA-seq) another seven samples vs. HER2 , 4 3) prospectively further explore differences of...
The aim of the present study was to investigate radiosensitizing effect genistein, and corresponding mechanisms action on breast cancer cells with different estrogen receptor (ER) status. Human cell lines such as MCF-7 (ER-positive, harboring wild-type p53) MDA-MB-231 (ER-negative, mutant were irradiated X-rays in presence or absence genistein. Cell survival, DNA damage repair, cycle distribution, apoptosis, expression proteins related G2/M checkpoint apoptosis measured colony formation...
Hepatocellular carcinoma (HCC) is a lethal disease, while the precise underlying molecular mechanisms of HCC pathogenesis remain to be defined. MicroRNA (miRNA), class non-coding small RNAs, can post-transcriptionally regulate gene expression. Altered miRNA expression has been reported in HCCs. This study assessed and oncogenic activity miRNA-10b (miR-10b) HCC.Forty-five paired human adjacent non-tumor tissues were collected for qRT-PCR immunohistochemistry analysis miR-10b CUB Sushi...
Background & Aims: Although progression to adenocarcinoma at the gastroesophageal junction reflects exposure acid and bile acids associated with reflux, mechanisms mediating this transformation remain undefined. Guanylyl cyclase C (GC-C), an intestine-specific tumor suppressor, may represent a mechanism-based marker target of junction. The present studies examine expression GC-C in normal tissues tumors from esophagus stomach regulating its by acids. Methods: Gene was examined...
BACKGROUND This study aimed to investigate the efficacy and safety of treatment with transcutaneous vagus nerve stimulation (tVNS) for patients refractory epilepsy by evaluation frequency seizures, electroencephalogram (EEG) changes, quality life on follow-up at three months six months. MATERIAL AND METHODS EEG followed baseline following tVNS treatment. The seizures was recorded during six-month period. Before after treatment, completed Self-Rating Anxiety Scale (SAS), Depression (SDS),...
Abstract We detected disproportionate reports of premature ovarian insufficiency (POI) and related events, including amenorrhea, menstruation irregular, FSH increased, menopause, following human papillomavirus (HPV) vaccine from FDA Vaccine Adverse Event Reporting System (VAERS). The signal was by the methods Bayesian Confidence Propagation Neural Network (BCPNN) Multi-item Gamma Poisson Shrinker (MGPS). When both a positive result, generated. Besides, time-scan map is drawn based on IC...
Abstract Although the incidence and mortality of gastric cancer (GC) are slowly decreasing, overall prognosis GC patients with distal metastasis remains dismal. Long non‐coding RNA PVT1 has been verified to function as a tumor promoter in several types cancer. However, role obscure. Herein, we found that was highly expressed tissues high level associated stage, lymph node metastasis, poor prognosis. Overexpression significantly elevated epithelial‐to‐mesenchymal transition (EMT) marker...
Purpose Diffuse midline gliomas (DMG) with H3K27M mutations have been identified as a rare distinctive entity unique genetic features, varied molecular alterations, and poor prognosis. The current study aimed to evaluate the clinical characteristics profile of markers on patients DMG harboring mutations, explore impact this makeup overall survival. Methods We retrospectively analyzed 43 consecutive diagnosed (age range 3 75 years) treated in tertiary institution within China between January...
Background Rapid On-Site Evaluation (ROSE) during flexible bronchoscopy (FB) can improve the adequacy of biopsy specimens and diagnostic yield lung cancer. However, lack cytopathologists has restricted wide use ROSE. Objective To develop a ROSE artificial intelligence (AI) system using deep learning techniques to differentiate malignant from benign lesions based on cytological images, evaluate clinical performance AI system. Method 6357 images 721 patients who underwent transbronchial were...
Abstract Unravelling the mechanisms for immunosuppressive tumor microenvironment and developing corresponding therapeutic strategies are of great importance to improve cancer immunotherapy. This study has revealed that there abundant senescent cells accumulated in colon tissue, which contributes greatly microenvironment. Oral delivery Dasatinib Quercetin (D+Q) eliminates with compromised efficiency due poor penetration short half‐life. To efficacy cell clearance, this work developed an...
Abstract Background NDRG 2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that expressed differentially normal and cancer tissues. Specifically, mRNA down-regulated or undetectable several human cancers, over-expression of inhibited the proliferation cells. also exerts important functions cell differentiation tumor suppression. However, it remains unclear whether participates carcinogenesis thyroid. Methods In this study, we...
The mitochondrial genomes (mitogenomes) of flatfishes (Pleuronectiformes) exhibit highly diversified types large-scale gene rearrangements. We have reported that the mitogenomes Crossorhombus azureus (Bothidae), Samariscus latus (Samaridae) and Cynoglossus fishes (Cynoglossidae) show different In present study, complete two Symphurus species (Cynoglossidae), plagiusa orientalis, were determined. order in S. mitogenome is same as a typical vertebrate (without any rearrangements)....
MicroRNA-21 has been proved to be associated with glioma proliferation and invasion; thus, we sought clarify the clinical value of miR-21 expression in tissues WHO grade I IV.One hundred fifty-two pairs human gliomas non-neoplastic brain were evaluated using real-time PCR. The association clinicopathological factors or prognosis patients was also analyzed. In this study, survival analysis performed Kaplan-Meier method Cox's proportional hazards model.MiR-21 more greatly expressed compared...
Abstract Focal segmental glomerulosclerosis (FSGS) is a frequent glomerular disease, and the common cause of nephrotic syndrome. However, there no validated diagnostic blood biomarker for FSGS. Here, we performed real-time PCR-based high-throughput miRNA profiling to identify plasma signature We found four miRNAs (miR-17, miR-451, miR-106a, miR-19b) were significantly downregulated in FSGS patients ( n = 97) compared with healthy controls 124) training, validation, blinded-test phases. The...