A5064703582- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Signaling Pathways in Disease
- Radiomics and Machine Learning in Medical Imaging
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
- Sperm and Testicular Function
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Reproductive Biology and Fertility
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Tea Polyphenols and Effects
- Immune Cell Function and Interaction
Peking University
2013-2024
Macau University of Science and Technology
2022-2024
King University
2024
Guangzhou Medical University
2021-2024
Taizhou University
2024
Hangzhou Medical College
2017-2024
Beijing University of Posts and Telecommunications
2024
Tsinghua University
2024
State Key Laboratory of New Ceramics and Fine Processing
2024
Dalian Ocean University
2022-2023
Abstract In face of the everlasting battle toward COVID-19 and rapid evolution SARS-CoV-2, no specific effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme 2 (ACE2), a receptor mediates virus infection by binding to spike protein. Although ACE2 is expressed in lung, kidney, intestine, its expressing levels are rather low, especially lung. Considering great infectivity COVID-19, we speculate that SARS-CoV-2 may depend on other routes...
The real-time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab had a relatively low positive rate in the early stage coronavirus disease 2019 (COVID-19). Meanwhile, manifestations COVID-19 as seen through computed tomography (CT) imaging show individual characteristics that differ those other types pneumonia such influenza-A (IAVP). This study aimed to establish an screening model distinguish IAVP and healthy cases pulmonary...
SUMMARY Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of disease, which poses great challenge to control and contain virus. Here, we reported a research finding that SARS-CoV-2 invaded host cells via novel route CD147-spike protein (SP). SP bound CD147, receptor on cells, thereby mediating viral invasion. Our further confirmed this...
SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape, compromising the effectiveness of existing vaccines neutralizing antibodies. An in-depth investigation on COVID-19 pathogenesis is urgently needed develop a strategy against variants. Here, we identified CD147 as universal receptor for its Meanwhile, Meplazeumab, humanized anti-CD147 antibody, could block cellular entry variants-alpha, beta, gamma, delta, with inhibition rates 68.7, 75.7, 52.1, 62.3% at 60...
At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome 2, is spreading all over the world, disastrous consequences for people of countries. The traditional Chinese medicine prescription Dayuanyin (DYY), a classic treatment plague, has shown significant effects in COVID-19. However, its specific mechanism action not yet been clarified. This study aims to explore DYY COVID-19 hope providing theoretical basis clinical application.First, TCMSP...
Terminally differentiated cells can be generated by lineage reprogramming, which is, however, hindered incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy mimicking the natural regeneration route, permits generating expandable hepatic progenitor functionally competent human hepatocytes. Fibroblasts were first induced into progenitor-like (hHPLCs), could robustly expand in vitro efficiently engraft vivo....
Background In E ast A sia, individuals systematically vaccinated at birth to hepatitis B virus ( HBV ) are an increasing part of the blood donor population. Their environment presents a high risk contact with . vaccine efficacy and potential safety carried by donors were examined. Study Design Methods total 2028 recruited in 2012 2013 tested for serologic (hepatitis surface antigen [ HBsAg ], antibody [anti‐ HBs core HBc ]) molecular DNA markers , anti‐ viral load quantified. Results Donors...
Recent studies have suggested that epigenetic alterations, particularly DNA methylation, play a crucial role in the pathogenesis of insulin resistance. Folate is key source one-carbon group for whereas association and mechanistic linkage between folate status resistance remains unclear with very limited experimental support. We performed cross-sectional study 1530 nondiabetic adults 2011-2012 National Health Nutrition Examination Survey (NHANES). examined associations serum using multiple...
We developed a deep learning model-based system to automatically generate quantitative Computed Tomography (CT) diagnostic report for Pulmonary Tuberculosis (PTB) cases.501 CT imaging datasets from 223 patients with active PTB were collected, and another 501 cases healthy population served as negative samples.2884 lesions of carefully labeled classified manually by professional radiologists.Three state-of-the-art 3D convolution neural network (CNN) models trained evaluated in the inspection...
Polyphenols extracted from Shanxi-aged vinegar (SAVEP) can alleviate oxidative stress and inflammatory caused by high-fat diets, improving intestinal microbial disorders. SAVEP may be a novel treatment of the metabolic syndrome.
Abstract The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron variant, sublineages BA.1 and BA.2, recently became the dominant variants of concern (VOCs) with significantly higher transmissibility than any other variant appeared markedly greater resistance to neutralization antibodies original ancestral WA1 spike‐matched vaccine. Therefore, it is urgent develop vaccines against VOCs like Omicron. Unlike new booming messenger RNA (mRNA) vaccine, protein have...
Epigallocatechin gallate (EGCG) is a main constituent of green tea polyphenols that are widely used as food preservatives and considered to be safe for consumption. However, the underlying antimicrobial mechanism EGCG bacterial response not clearly understood. In present study, genome-wide transcriptional analysis typical spoilage bacterium, Pseudomonas fluorescens responded was performed using RNA-seq technology. A total 26,365,414 23,287,092 clean reads were generated from P. treated with...
Melanocortin 4 receptor (MC4R), which is associated with inherited human obesity, involoved in food intake and body weight of mammals. To study the relationships between MC4R gene polymorphism Beagle dogs, we detected compared nucleotide sequence whole coding region 3'- 5'- flanking regions dog (1214 bp). In 120 two SNPs (A420C, C895T) were identified their relation was analyzed RFLP-PCR method. The results showed that SNP at A420C significantly canine trait when it changed amino acid 101...
In this study, we aimed to explore the potential differences in proteomic profiles from testicular tissue of azoospermatic men with impaired spermatogenesis and normal spermatogenesis. Isobaric tags for relative absolute quantitation (iTRAQ) labeled technology LC-MS/MS were used identify differentially expressed proteins. Potential functions proteins predicted using gene ontology (GO) Kyoto encyclopedia genes genomes (KEGG). Immunohistochemistry (IHC) western blot (WB) verify A...
The SARS-CoV-2 Omicron BA.1 variant of concern contains more than 30 mutations in the spike protein, with half these localized receptor-binding domain (RBD). Emerging evidence suggests that large number impact neutralizing efficacy vaccines and monoclonal antibodies. We investigated relative contributions protein RBD variants on infectivity, cell-cell fusion, their sensitivity to neutralization by antibodies or vaccinated sera from individuals who received homologous (CoronaVac, SinoPharm)...
Occult hepatitis B virus infection (OBI) carries a risk of (HBV) transmission and hepatocellular carcinoma. As previous studies have had limited sample size, the characteristics OBI with genotype C (OBIB OBIC) mutations relating to surface antibody (anti-HBs) elicited by vaccination or host immune response HBV not been fully explored.In this study, occurrence OBIB OBIC strains associated envelope protein (pre-S/S) amino acid substitutions obtained from 99 blood donors stratified according...
Hyperlipidemia (HLP), a common complication, is very prevalent in children with primary nephrotic syndrome (PNS). HLP not only significantly increases the cardiovascular risk adulthood, but also accelerates progression of renal disease. Proteinuria as most important pathophysiological change can reduce serum colloid osmotic pressure, which leads to an increase synthesis proteins including lipoproteins liver for export serum. Thus, severity lipid abnormalities may correlate degree...