A5054327155- Mitochondrial Function and Pathology
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Thyroid and Parathyroid Surgery
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Kidney Stones and Urolithiasis Treatments
- Vitamin D Research Studies
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Hedgehog Signaling Pathway Studies
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
Anhui Medical University
2025
Sichuan University
2025
Guangzhou Medical University
2015-2025
Shenzhen University
2024-2025
Shenzhen MSU-BIT University
2024-2025
Shanghai East Hospital
2017-2024
Materials Technology (United Kingdom)
2024
Chinese University of Hong Kong, Shenzhen
2024
Sichuan Cancer Hospital
2015-2024
University of Electronic Science and Technology of China
2023-2024
Abstract Papillary thyroid carcinoma (PTC) is the main type of carcinoma. Despite good prognosis, some PTC patients may deteriorate into more aggressive diseases, leading to poor survival. Molecular technology has been increasingly used in diagnosis and treatment In this study, we identified that RNA Binding Motif Protein 47 (RBM47) was downregulated tissues cells, overexpression RBM47 could activate autophagy inhibit proliferation cells. promotes but can not bind directly Forkhead Box O3...
Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility developing an AI-defined protein-based biomarker panel for classification nodules: based initially on formalin-fixed paraffin-embedded (FFPE), further refined fine-needle aspiration (FNA) tissue specimens minute amounts which pose technical challenges other methods. We first developed neural network model 19 protein biomarkers proteomes 1724 FFPE samples...
Abstract Nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA (lncRNA), is core structural component of paraspeckles and essential for formation. NEAT1 comprises two different isoforms: NEAT1_1 (3.7 kb) NEAT1_2 (23 kb). Recently, has been shown to have oncogenic roles facilitate tumorigenesis in various human cancers. However, the function papillary thyroid cancer (PTC) not well understood. The relative expression levels NEAT1_2, ATPase family AAA domain-containing...
Abstract Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, role in formation astrogliosis glial scar remains unknown. Here, a transient middle cerebral artery occlusion (tMCAO) rat model an oxygen glucose deprivation reoxygenation (OGD/Re)-induced injury model, we show was significantly elevated reactive...
Mitochondria are highly dynamic organelles, constantly undergoing shape changes, which controlled by mitochondrial movement, fusion, and fission. play a pivotal role in various cellular processes under physiological pathological conditions, including metabolism, superoxide generation, calcium homeostasis, apoptosis. Abnormal morphology protein expression always closely related to the health status of cells. Analysis situ is widely used reflect abnormality cell function chemical fixed sample....
Abstract Mitochondrial fusion and fission are essential for heart function. Abrogating mitochondrial dynamism leads to cardiomyopathy. Excessive fragmentation is involved in most diseases, thus enhancing will be a potential therapeutic strategy. To understand the effects of promoting adult cardiac, we investigated mice hearts, cultured murine embryonic fibroblasts (MEFs), which mitofusin 2 (Mfn2) overexpressed or dynamin‐related protein 1 (Drp1) was abrogated concomitantly forcing fusion....
NEAT1 (nuclear paraspeckle assembly transcript 1) is an oncogenic long non-coding RNA (lncRNA) that facilitates tumorigenesis in multiple cancers. In papillary thyroid cancer (PTC), the molecular mechanism by which affects invasion and metastasis remains elusive. sequencing was used to discover differentially expressed NEAT1_2 downstream genes. Protein expression analyses immunohistochemistry detected of , Transglutaminase 2 (TGM2), microRNA-491 (miR-491) among PTC non-cancerous tissues....
This study aimed to establish a prognostic model related prostate cancer (PCa) recurrence-free survival (RFS) and identify biomarkers.The RFS key genes associated with PCa were established using Least Absolute Shrinkage Selection Operator (LASSO) Cox regression from the Cancer Genome Atlas (TCGA)-PRAD Gene Expression Omnibus (GEO) GSE46602 datasets. The weighted gene co-expression network (WGCNA) was used analyze obtained modules genes, set enrichment analysis (GSEA) performed. phenotype...
Abstract Epigenetic dysregulation plays an important role in cancer. Histone demethylation is a well‐known mechanism of epigenetic regulation that promotes or inhibits tumourigenesis various malignant tumours. However, the pathogenic histone modifiers papillary thyroid cancer (PTC), which has high incidence early lymphatic metastasis, largely unknown. Here, we detected expression common and found H3 lysine 4 (H3K4) 9 (H3K9) demethylase KDM1A (or 1A) frequently overexpressed PTC tissues cell...
Long non-coding RNAs (lncRNAs) play an essential regulatory role in multiple cancers. However, the of lncRNAs papillary thyroid carcinoma (PTC) is still unknown. Here, GAS8-AS1, a novel lncRNA that significantly downregulated PTC, was selected for further investigation. The roles GAS8-AS1 PTC cells were verified by gain- and loss-of-function experiments. functional mechanism on microRNA (miR)-187-3p/ATG5 axis miR-1343-3p/ATG7 evaluated using bioinformatics analysis, luciferase reporter...
Myocardial infarction (MI) remains a major cause of chronic heart failure. Endoplasmic reticulum (ER) stress is an emerging therapeutic strategy to prevent adverse remodeling the infarcted heart. However, little known about how Bax-interacting protein 1 (Bif-1), member endophilin B family, involved in mediating cardiac ER ischemic disease. Here, combination left anterior descending (LAD) coronary artery ligation mouse model and adenovirus-based transfection was used investigate effect Bif-1...