A5101634760- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Advanced Proteomics Techniques and Applications
- Urinary Bladder and Prostate Research
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal and related cancers
- Xenotransplantation and immune response
- Lung Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- IL-33, ST2, and ILC Pathways
- Cardiovascular Disease and Adiposity
Central South University
2019-2025
Dalian Medical University
2017-2025
Second Affiliated Hospital of Dalian Medical University
2017-2025
Guangzhou Medical University
2025
National Institutes of Health Clinical Center
2025
Zhuzhou Central Hospital
2018-2025
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
National Clinical Research Center for Digestive Diseases
2024
Sun Yat-sen University
2005-2023
Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility developing an AI-defined protein-based biomarker panel for classification nodules: based initially on formalin-fixed paraffin-embedded (FFPE), further refined fine-needle aspiration (FNA) tissue specimens minute amounts which pose technical challenges other methods. We first developed neural network model 19 protein biomarkers proteomes 1724 FFPE samples...
Background: Currently, there are no molecular biomarkers for the early detection of non-small-cell lung cancer (NSCLC). This study focused on identifying RNAs found tumor-educated blood platelets (TEPs) detecting stage I NSCLC. Methods: Platelet RNAs, isolated from 9 patients with NSCLC (stages and II) 8 healthy controls, were analyzed using RNA-seq. ITGA2B was selected as a candidate marker. Two different Polymerase Chain Reactions (PCR) used to measure in platelet samples controls (n =...
Induction of ferroptosis is an emerging strategy to suppress melanoma progression. Strategies enhance the sensitivity induction would be a major advance in therapy. Here, we used drug synergy screen that combined inducer, RSL3, with 240 anti-tumor drugs from FDA-approved library and identified lorlatinib synergize RSL3 cells. We further demonstrated sensitized through inhibiting PI3K/AKT/mTOR signaling axis its downstream SCD expression. Moreover, found lorlatinib's target IGF1R, but not ALK...
The prognosis of oral squamous cell carcinoma (OSCC) patients is difficult to predict or describe due its high-level heterogeneity and complex aetiologic factors. Ferroptosis a novel form iron-dependent death that closely related tumour growth progression. This study aims clarify the predictive value ferroptosis-related genes (FRGs) on overall survival(OS) OSCC patients.The mRNA expression profile FRGs clinical information with were collected from TCGA database. Candidate differentially...
Thyroid nodules occur in about 60% of the population. A major challenge thyroid nodule diagnosis is to distinguish between follicular adenoma (FA) and carcinoma (FTC). Here, we present a comprehensive spectral library covering five types tissues. This includes 121 960 peptides 9941 protein groups. can be used quantify up 7863 proteins from tissues, also develop parallel reaction monitoring (PRM) assays for targeted quantification. Next, stratify tumours, compared proteomes 24 FA 22 FTC...
To further explore characteristics of myopia and changes in factors associated with among students at Inner Mongolia Medical University. Two cross-sectional censuses were conducted 2011 2013. Participants medical residing on campus Logistic regression analysis was performed to ascertain associations basic information, genetic factors, environmental factors. The χ2 test used for differences prevalence between Prevalence calculated various occurrence times different parental statuses. A total...
Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) important regulator in T2D, but the role ANGPTL8 diabetes-associated dysfunction remains unknown. Here, we explored through its interaction paired immunoglobulin-like receptor B (PirB) central nervous system.
Pericardial adipose tissue, which comprises both epicardial tissue (EAT) and paracardial (PAT), has recently been recognized as a novel factor in the pathophysiology of cardiovascular diseases, especially coronary artery disease (CAD). The goal this study was to evaluate differences brown-like characteristic proteome among human EAT, PAT, subcutaneous (SAT) identify candidate molecules causing CAD. Uncoupling protein 1 (UCP-1) other brown-related proteins were highly expressed pericardial...
Abstract Background Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis copper triggered cell mode. In this study, we explored biological effects lidocaine on cuproptosis in Hep-2 cells and studied relevant mechanisms. Methods quantitative RT-PCR was used measure expression level long noncoding RNA (IncRNA) DNMBP-AS1. DNMBP-AS1 siRNA (si-DNMBP-AS1) were transfected...
Abstract Prostate cancer (PCa) ranks as the second most common malignancy and fifth leading cause of cancer-related deaths among men. A critical challenge lies in accurately identifying those patients at high risk for transitioning rapidly from hormone-sensitive PCa (HSPC) to lethal castration-resistant (CRPC). In our study, we employed a multiomics approach involving bioinformatics analysis on datasets GSE2443 GSE35988, along with proteomics studies, discover that cysteine- glycine-rich...
Abstract Ebola virus (EBOV) and Marburg (MARV) are zoonotic filoviruses that cause hemorrhagic fever in humans. Correlative data implicate bats as natural EBOV hosts, but neither a full-length genome nor an isolate has been found any sampled. Here, we model filovirus infection the Jamaican fruit bat (JFB), Artibeus jamaicensis, by inoculation with either or MARV through combination of oral, intranasal, subcutaneous routes. Infection results systemic replication oral shedding infectious...
Diffuse-type tenosynovial giant cell tumor (D-TGCT) and localized-type (L-TGCT) share common genomic aberrations histopathological features, but the former has a more aggressive nature higher recurrence rate, leading to worse prognoses for patients. In this study, single-cell RNA sequencing (scRNA-seq) on human D-TGCT L-TGCT lesions is conducted discover transcriptional differences. A unique cluster of cells in identified that regulated differentiation CD34+ fibroblasts into MMP3+ or APOE+...
Abstract Background This study aimed to evaluate the prognostic significance of lactate dehydrogenase (LDH) and fasting triglyceride-glucose (TyG) index in advanced hormone-sensitive prostate cancer (HSPC) patients, with ultimate goal developing validating a nomogram for predicting castration-resistant (CRPC) free survival. Materials methods The follow-up data 207 CRPC patients who had androgen deprivation therapy as their initial only treatment before progression were retrospectively...
Acute kidney injury (AKI) is a common clinical condition that confers risk of progression chronic disease and high death. The purpose the current study to investigate anti-apoptotic anti-fibrotic effects Zhen-Wu-Tang (ZWT) on cisplatin (CIS)-induced renal elucidate involvement nuclear factor (erythroid-derived 2)-like 2 (Nrf2), PI3K/Akt signaling pathway, transforming growth (TGF)-β Wnt/β-catenin pathway in positive kidneys. Wistar rats were randomly assigned into six groups 6 each as...
Granulosa cells (GCs) play a critical role in driving the formation of ovarian follicles and building cumulus-oocyte complex surrounding ovum. We are particularly interested assessing oocyte quality by examining detailed gene expression profiles human cumulus single cells. Using single-cell RNAseq techniques, we extensively investigated transcriptomes GC populations from two women with normal function. This allowed us to elucidate endogenous heterogeneity GCs uncovering hidden subpopulation....
Collagen type I α 2 (COL1A2) is a major component of collagen I. Recently, abnormal COL1A2 expression has been reported in human cancers. However, the specific role and mechanism colon adenocarcinoma (COAD) remain unclear. We performed pan-cancer analysis 33 types cancers from TIMER database integrated data combined TCGA with GTEx. The prognostic values for 17 cancer interest were estimated GEPIA database. results showed that was significantly upregulated COAD tissues higher predicted...
Effective means for early diagnosis are imperative to reduce death rate of non-small cell lung cancer (NSCLC) patients. We aimed find out high-performance serologic markers distinguish early-stage NSCLC patients from benign pulmonary nodule and healthy controls (HC). Cystatin-SN (CST1) is an active cysteine protease inhibitor the CST superfamily, involving in processes inflammation tumorigenesis. This first exploration diagnostic prognostic values serum CST1 NSCLC.We analyzed transcriptome...
Serum lipids were reported to be the prognostic factors of various cancers, but their value in small cell lung cancer (SCLC) patients remains unclear. This study investigated relationship between lipid profiles and clinical outcomes extensive-stage (ES) SCLC by establishing a predictive risk classification model.We retrospectively analyzed values pretreatment serum derivatives with confirmed diagnosis ES-SCLC. Independent progression-free survival (PFS) determined univariate multivariate cox...
Magnetic graphene oxide nanocomposites (MGO NPs) have been widely studied in biomedical applications. However, their cytotoxicity and underlying mechanisms remain unclear. In this study, the biosafety of MGO NPs was investigated, mechanism involved ferroptosis further explored. can produce ADSCs, which is dependent on concentration. Ferroptosis NP-induced ADSC survival inhibition by increasing total ROS lipid accumulation as well regulating expression levels ferroptosis-related genes...
Differentiating follicular thyroid adenoma (FTA) from carcinoma (FTC) remains challenging due to similar histological features separate invasion. In this study, we aim develop and validate DNA protein-based classifiers for FTA/FTC differentiation. We collected 2443 samples 1568 patients across 24 centers applied next-generation sequencing, as well discovery targeted proteomics. Machine learning models were developed compared utilizing and/or protein features. The model (AUC 0.899)...
Summary Ebola virus (EBOV) and Marburg (MARV) are zoonotic filoviruses that cause hemorrhagic fever in humans. Bat species both Chiropteran suborders host filoviruses, suggesting bats may have coevolved with this viral family. Correlative data implicate as natural EBOV hosts, but neither a full-length genome nor an isolate has been found any sampled. Here, we modelled filovirus infection the Jamaican fruit bat (JFB), Artibeus jamaicensis . Bats were inoculated either or MARV through...