A5100320356- Reproductive Biology and Fertility
- Ovarian function and disorders
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Health and Technologies
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Renal and related cancers
- Demographic Trends and Gender Preferences
- Ovarian cancer diagnosis and treatment
- Gynecological conditions and treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Family Dynamics and Relationships
- Kruppel-like factors research
- Uterine Myomas and Treatments
- Protease and Inhibitor Mechanisms
- Gender Studies in Language
- Cancer Mechanisms and Therapy
- Mechanisms of cancer metastasis
- Advanced Neuroimaging Techniques and Applications
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
Central South University
2017-2024
Chengdu Women's and Children's Central Hospital
2024
Chengdu Medical College
2024
International Peace Maternity & Child Health Hospital
2022-2024
Shanghai Jiao Tong University
2022-2024
Reproductive & Genetic Hospital CITIC-Xiangya
2017-2024
Institute of Electrical and Electronics Engineers
2024
Gorgias Press (United States)
2024
Shanghai Institute of Hematology
2023
Second Military Medical University
2006-2023
Background The genetic causes of the majority male and female infertility caused by human non-obstructive azoospermia (NOA) premature ovarian insufficiency (POI) with meiotic arrest are unknown. Objective To identify cause NOA POI in two affected members from a consanguineous Chinese family. Methods We performed whole-exome sequencing DNA both patients. identified candidate causative gene was further verified Sanger for pedigree analysis this In silico to functionally characterise mutation,...
The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) an attempt identify potential core genes pathogenesis this tumor.Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and normal brain samples using Illumina Hiseq. Bioinformatics analysis was used analyze their function. CircBRAF further detected different WHO grades glioma tissues. Kaplan-Meier curves multivariate Cox's association...
Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology vast majority remains unclear. Here we describe three with primary multiple morphological abnormalities sperm flagella (MMAF) from two unrelated Han Chinese families. We performed whole-exome sequencing (WES) and Sanger on proband family 1, found that he carried novel compound heterozygous missense mutations in dynein axonemal heavy chain 6 (DNAH6) resulted substitution a...
With a high rate of infertility, it is important to understand the context fertility and family planning in China, inform necessity supportive care. A literature review was undertaken explore societal constructs informing perspectives childbearing, alongside Chinese considerations treatments, including assisted reproductive technologies counselling. In childbearing attitudes behaviours are shaped by tensions between traditional cultural values filial piety originating from Confucianism,...
Background: At present, fertility is one of the main concerns young cancer patients. Following this trend, "fertility preservation (FP)" has been established and become a new field reproductive medicine. However, FP for child adolescent (C-A) patients still developing, even in advanced countries. The aim present study was to assess barriers C-A by investigating current status Asian countries, which just have started activities. Method: A questionnaire survey founding members Society...
Orderly and stage-specifically expressed proteins are essential for spermatogenesis, proteases play a key role in protein activation function. The present study aimed to investigate serine protease 55 (PRSS55), which was reported sperm-uterotubal junction (UTJ) migration sperm-zona pellucida (ZP) binding. We found that PRSS55 specifically testicular spermatids epididymal spermatozoa. By constructing knockout mice targeting all transcripts of Prss55, we demonstrated deletion Prss55 resulted...
Granulosa cells (GCs) play a critical role in driving the formation of ovarian follicles and building cumulus-oocyte complex surrounding ovum. We are particularly interested assessing oocyte quality by examining detailed gene expression profiles human cumulus single cells. Using single-cell RNAseq techniques, we extensively investigated transcriptomes GC populations from two women with normal function. This allowed us to elucidate endogenous heterogeneity GCs uncovering hidden subpopulation....
Gender dysphoria (GD) is characterized by an incongruence between the gender assigned at birth and with which one identifies. The biological mechanisms of GD are unclear. While common genetic variants associated GD, positive findings have not always been replicated. To explore role rare in susceptibility within Han Chinese population, whole-genome sequencing 9 female-to-male transsexuals (FtMs) whole-exome 4 male-to-female (MtFs) were analyzed using a pathway burden analysis first collapsed...
Previous studies have found that women with polycystic ovary syndrome (PCOS) some degree of brain function change as well cognitive and emotions, such poor executive functioning memory, anxiety depressive symptoms. However, the neurobiological mechanisms underlying these alterations not yet been clarified.Fasting serum hormone testing, neuropsychological testing resting-state magnetic resonance imaging (rs-fMRI) were performed in 41 newly diagnosed PCOS healthy controls matched by age...
Abstract The characteristic tadpole shape of sperm is formed from round spermatids via spermiogenesis, a process which results in dramatic morphological changes the final stage spermatogenesis testis. Protein phosphorylation, as one most important post‐translational modifications, can regulate spermiogenesis; however, phosphorylation events taking place during this have not been systematically analyzed. In order to better understand role large‐scale phosphoproteome profiling performed using...
Preeclampsia (PE) is a pregnancy-related disease defined as onset of hypertension and proteinuria after the 20th week pregnancy, which causes most maternal perinatal morbidity mortality. Although placental dysfunction considered main cause PE, exact pathogenesis PE not yet fully understood. Long non-coding RNAs (lncRNAs) are implicated in broad range physiological pathological processes, including occurrence PE. In this study, we investigated expression functions HIF-1α pathway–related...
Abstract Background Endometrial fibrosis caused by intrauterine adhesion (IUA) can lead to hypomenorrhea, amenorrhea, and even infertility abortion. The postoperative recurrence rate of severe IUA remains high, giving rise low pregnancy rates. An extracellular matrix (ECM) scaffold, a new biological material that promote cell proliferation differentiation at lesions, has been widely used in general surgery neurosurgery. present study applied ECM scaffolds obstetrics gynecology for the first...
Normal implantation and placental development depend on the appropriate differentiation invasion of trophoblast cells. Inadequate cell results in pregnancy-related disorders, which endanger both mother fetus; however, mechanism early has not been fully explained. In this study we conducted gene expression profile analysis using mouse tissues at different developmental stages (embryonic day (E)7.5, E14.5 E19.5) series tests cluster (STC) Kyoto Encyclopaedia Genes Genomes (KEGG) pathway...
Oil content is a primary trait in soybean and determines the quality of soy food, feed oil product. Increasing major objective breeding. The aims present study were to identify quantitative loci (QTLs) epistatic QTLs associated with seed by using 129 recombinant inbred lines derived from cross between cultivar Dongnong 46 (oil 22.53%) semi-wild line L-100 17.33%). Phenotypic data collected 10 tested environments including Harbin years 2012–15, Hulan 2013–15 Acheng 2013–15. A genetic linkage...
Premature ovarian insufficiency (POI) is affecting about 1% women of reproductive age. However, current studies have primarily focused on with the views male partners greatly absent from literature. We conduct this research to investigate psychosocial effect POI and their perceptions disease.52 patient (experiment group) 52 controls (control were available for analysis. Anxiety, depression, marital relationship assessed in both groups. A questionnaire was completed by experiment group. Male...
This randomised clinical pilot study evaluated the effect of mid-luteal additional single dose gonadotropin-releasing hormone agonist (GnRH-a) on outcome females subjected to artificial cycle frozen-thawed embryo transfer (AC-FET).A total 129 were into two groups (70 in control group and 59 intervention group). Both received standard luteal support. The was given an extra 0.1 mg GnRH-a phase. live birth rate served as primary endpoint. secondary endpoints positivity pregnancy tests, rate,...
Abstract Background Polycystic ovary syndrome (PCOS), an incidence of 10–15% in women reproductive age, shows sex hormone disorders, luteal insufficiency, and the tendency placental villus space thrombus. The early pregnancy loss with PCOS is three to eight times higher than that non-PCOS women. were reported a pre-thrombotic state, which was manifested by accelerated thrombin production, increased PAI-1 activity, fibrinogen. Other research also found over-activated state immune system....
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