A5101754093- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Biochemical and Molecular Research
- Folate and B Vitamins Research
- Nitric Oxide and Endothelin Effects
- Remote Sensing and Land Use
- Liver Disease Diagnosis and Treatment
- Regional Economic and Spatial Analysis
- Chinese history and philosophy
- Nuclear Receptors and Signaling
- Chronic Kidney Disease and Diabetes
- Genomics, phytochemicals, and oxidative stress
- Dietary Effects on Health
- Environmental Changes in China
- Lipid metabolism and disorders
- Genetic Associations and Epidemiology
- Galectins and Cancer Biology
- Demographic Trends and Gender Preferences
- Genomic variations and chromosomal abnormalities
- Global Educational Reforms and Inequalities
Zhejiang University
2020-2025
Women's Hospital, School of Medicine, Zhejiang University
2020-2025
Tongren Hospital
2018-2022
Wuhan University
2022
Princeton University
2022
Shanghai Jiao Tong University
2018-2021
China Pharmaceutical University
2018-2020
Women's Hospital
2020
Southeast University
2020
Second Military Medical University
2017
The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) an attempt identify potential core genes pathogenesis this tumor.Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and normal brain samples using Illumina Hiseq. Bioinformatics analysis was used analyze their function. CircBRAF further detected different WHO grades glioma tissues. Kaplan-Meier curves multivariate Cox's association...
Abstract Accumulating evidence has indicated the significant roles of long noncoding RNAs (lncRNAs) in pathophysiology diabetic nephropathy (DN). LncRNA nuclear enriched abundant transcript 1 (NEAT1) been reported to exert a key role progression several diseases including diabetes. However, NEAT1 regulation DP remains barely known. Therefore, our study aimed investigate streptozotocin‐induced diabetes model (DM) rats and glucose‐induced mouse mesangial cell models. Currently, we found that...
Diabetic nephropathy (DN) is one of the leading causes end-stage renal diseases worldwide.This study designed to investigate underlying function and mechanism a novel lncRNA GAS5 in progression DN.We found that expression level was decreased type 2 diabetes (T2D) with DN compared patients without DN.Moreover, negatively associated severity DN-related complications.lncRNA inhibited MCs proliferation caused G0/1 phase arrest.lncRNA overexpression alleviated fibrosis-related protein mesangial...
Abstract Goose can develop severe hepatic steatosis without overt injury, thus it may serve as a unique model for uncovering how steatosis-related injury is prevented. To identify the markedly prosteatotic and protective mechanisms, we performed an integrated analysis of liver transcriptomes gut microbial metagenomes using samples collected from overfed normally-fed geese at different time points. The results indicated that fatty transcriptome, initially featuring ‘metabolism’ pathway, was...
Abstract Background Circular RNAs (circRNAs) have been reported to play key roles in the development of various cancers. However, biological functions and clinical significance most circRNAs are still elusive. The purpose this study was explore function mechanism a certain circRNA named circCDKN2B-AS1 cervical cancer its potential value clinic. Methods qRT-PCR used verify expression level circCDKN2B-AS1. CCK-8, Transwell, flow cytometry (FCM) assays were performed detect cellular...
Abstract Circular RNAs play essential roles in the development of various human diseases. However, how circRNAs are involved diabetic nephropathy (DN) not fully understood. Our study aimed to investigate effects circRNA circEIF4G2 on DN. Experiments were performed db/db mouse model type 2 diabetes and NRK‐52E cells. We found that was significantly up‐regulated kidneys mice cells stimulated by high glucose. knockdown inhibited expressions TGF‐β1, Collagen I Fibronectin glucose‐stimulated...
Abstract The prognosis of advanced stage cervical cancer is poorer due to invasion and metastasis. Exploring new factors signalling pathways associated with invasiveness metastasis would help identify therapeutic targets for cancer. We searched the microarray database, Oncomine, found elevated calponin 3 (CNN3) mRNA expression in tissues. QRT-PCR verified increased CNN3 compared para-cancer Proliferation, migration assays showed that overexpressed promoted viability motility cells, opposite...
A recent trend of tiger parenting and involution practices has emerged among parents in China, with which over the western contexts shares many key features. Our study, based on a regionally representative survey 1,412 Chinese parents, explored one crucial element new – parental expectations, reference to research findings west. Although primary caregiver children was more likely be mother China as elsewhere, it father who held high expectation that ought honor their life success. Unlike...
Cervical cancer progresses through distinct precancerous stages, making early screening and intervention crucial for prevention. However, conventional modalities, such as cytology HPV testing, face challenges related to sensitivity, specificity, resource dependency. Circular RNAs (circRNAs), owing their high stability tissue-specific expression, have emerged promising biomarkers, though role in cervical carcinogenesis remains underexplored. In particular, the clinical utility of circRNAs...
Diabetic retinopathy (DR) is a type of diabetes complication, which can result in loss vision adults worldwide. Increasing evidence has revealed that microRNAs (miRs) regulate DR progression. Thus, the present study was aimed at assessing possible mechanism miR-139-5p high glucose- (HG-) incubated retinal pigment epithelial (ARPE-19) cells. The results demonstrated expression notably reduced serum samples patients with DR, as well ARPE-19 cells treated HG time-dependent manner. Moreover,...
Objective To identify the risk factors for diabetic kidney disease (DKD) development, especially difference between patients with different courses. Patients and methods 791 were considered to be eligible enrolled in cross-sectional study from Shanghai Tongren Hospital Inpatient Department. 36 variables initially screened by univariate analysis. The affecting progression of DKD determined logistics regression Subgroups grouped according course diabetes disease, multivariate analysis was...
Fluorescent probes have been considered to be efficient tools for the visualization of physiological and pathological processes. Herein, a dual-site fluorescence probe denoted as LC-1 was developed detection cysteine (Cys) its metabolite SO3 2-. The shown highly sensitive Cys 2- with turn-on mode signal through two emission channels under excitations at wavelengths 320 nm 440 nm. Notably, also observed satisfactorily in presence other amino acids reactive oxygen species (ROS). Meanwhile, low...
Chromosome conformation capture (3C) is a biochemical technology to analyse contact frequencies between selected genomic sites in cell population. Its recent variants, e.g. Hi-C/ chromatin interaction analysis by paired-end tag (ChIA-PET), have enabled the study of nuclear organization at an unprecedented level. However, due inherent low resolution and ultrahigh cost Hi-C/ChIA-PET, 3C still gold standard for determining interactions given regulatory DNA elements, such as enhancers promoters....
A novel small molecule fluorescent probe <bold>NC-Cys</bold> for monitoring cysteine based on dihydronaphthalene was developed.
Insulin resistance is associated with impaired glucose uptake and altered protein kinase B (Akt) signaling. Previous studies have suggested asymmetric dimethylarginine (ADMA) inflammation are two distinguish factors that correlate insulin (IR). How ADMA interact synchronize in the regulation of IR liver remain to be elucidated. In this study, we systematically investigated whether involved using primary hepatocytes, if yes, by via which molecular mechanism. Our results demonstrated inhibits...