A5100654589- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Click Chemistry and Applications
- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- Biochemical and Structural Characterization
- RNA Interference and Gene Delivery
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Asymmetric Hydrogenation and Catalysis
- Cyclopropane Reaction Mechanisms
- Natural product bioactivities and synthesis
- Luminescence and Fluorescent Materials
- Immune Response and Inflammation
- Protein Hydrolysis and Bioactive Peptides
- Diabetes Treatment and Management
- Lipid Membrane Structure and Behavior
- Acute Kidney Injury Research
La Trobe University
2023-2025
The University of Melbourne
2015-2024
Peking University People's Hospital
2020-2024
Peking University
2020-2024
Kunming Medical University
2024
Hengyang Normal University
2021-2024
Royal Dental Hospital of Melbourne
2021-2024
Shanghai Jiao Tong University
2022-2024
Beijing Tian Tan Hospital
2021-2024
Capital Medical University
2021-2024
Abstract Dental implants are the most common therapeutic approach for resolving tooth loss and damage. Despite technical advances in treatment, implant failure rates can be as high 23% with major cause of peri‐implantitis: a multi‐species bacterial infection. With an annual growth rate placements 8.78% per annum, caused by infection is significant oral general health issue. The rise antibiotic resistance bacteria further adds pressure to failure; thus, there need adjunctive therapy improve...
Abstract Antimicrobial peptides (AMPs) are potentially powerful alternatives to conventional antibiotics in combating multidrug resistance, given their broad spectrum of activity. They mainly interact with cell membranes through surface electrostatic potentials and the formation secondary structures, resulting permeability destruction target microorganism membranes. Our earlier work showed that two leading AMPs, MSI‐78 (4–20) pardaxin (1–22), had potent antimicrobial activity against a range...
An efficient protocol for the selective synthesis of α-mono or α,α′-dihalo ketones <italic>via</italic> a water-controlled chemodivergent and regiospecific cascade reaction has been developed.
Antimicrobial peptides (AMPs) are host defense peptides, and unlike conventional antibiotics, they possess potent broad spectrum activities and, induce little or no antimicrobial resistance. They attractive lead molecules for rational development to improve their therapeutic index. Our current studies examined dimerization of the
A simple and efficient route for the synthesis of <italic>Z</italic>-β-sulfonyl-α,β-unsaturated carbonyl compounds by using water as solvent hydrogen source is developed.
Pioglitazone is effective in improving insulin resistance and liver histology patients with nonalcoholic steatohepatitis (NASH). Because dysfunctional mitochondrial metabolism a central feature of NASH, we hypothesized that an important target pioglitazone would be alleviating oxidative dysfunction. To this end, studied hepatic mice fed high-fructose high-transfat diet (TFD) supplemented for 20 wk, using nuclear magnetic resonance-based 13C isotopomer analysis. improved whole body adipose...
As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AMPs) represent promising class of compounds to help address this global issue. AMPs best-known for their membrane-disruptive mode action leading cell lysis and death. However, many also known be non-lytic have intracellular modes action. Proline-rich (PrAMPs) one such class, that generally membrane permeable inhibit protein synthesis bactericidal outcome. PrAMPs...
Herein we report an electrochemical strategy for the construction of polysubstituted oxazoles from easily available ketones and acetonitrile under room temperature. The method shows high efficiency, a broad substrate scope, requires no external chemical oxidant. Mechanistic investigations suggest that reaction proceeds through Ritter-type reaction/oxidative cyclization using as reactant solvent. X-ray crystallographic analysis reveals involves attack on carbonyl carbon instead α-carbon.
Antibiotic resistance in bacteria, especially Gram-positive bacteria like Staphylococcus aureus, is gaining considerable momentum worldwide and unless checked will pose a global health crisis. With few new antibiotics coming on the market, there need for novel antimicrobial materials that target kill multi-drug-resistant (MDR) pathogens methicillin-resistant aureus (MRSA). In this study, using mixed-bacteria assay, we show star-peptide polymers preferentially including MRSA. A major effect...
To investigate the association between neuropsychiatric symptoms (NPS) and nutritional status, explore their shared regulatory brain regions on Alzheimer's disease (AD) continuum. A longitudinal, observational cohort study. Data were collected from Chinese Imaging, Biomarkers, Lifestyle study June 1, 2021 December 31, 2022. Overall, 432 patients AD continuum, including amnestic mild cognitive impairment dementia, assessed at baseline, only 165 completed (10.37 ± 6.08) months' follow-up. The...
The highly enantioselective Michael addition of malonates to α,β-unsaturated ketones in water was reported be catalyzed by a primary−secondary diamine catalyst containing long alkyl chain. This asymmetric process found effective for variety ketones.
We report the atom-economic and environmentally friendly synthesis of Z-β-sulfonyl-a,β-unsaturated carbonyl compounds in water. The mechanism study reveals that hydrosulfonylation alkynylcarbonyl with sulfinic acids proceeds via a features acid molecule protonating an alkynyl motif to form ethenium intermediate, which subsequently reacted sulfonyl anion afford desired products. intermediate differentiated electronic steric demands between two substituents on C≡C triple bond alkyne substrates...
The chemical formation of the peptide bond has long fascinated and challenged organic chemists. It requires not only activation carboxyl group an amino acid but also protection Nα-amino group. more than a century continuous development ever-improved protecting chemistry been married to dramatic advances in synthesis peptides that, itself, was substantially enhanced by solid-phase R. B. Merrifield 1960s. While latter technology continued undergo further refinement improvement both its...